Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization
Depressive disorders are among the most common psychiatric conditions and contribute to significant morbidity. Even though the use of antidepressants revolutionized the management of depression and had a tremendous positive impact on the patient's outcome, a significant proportion of patients w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.886918/full |
| _version_ | 1828413876933230592 |
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| author | Mohamed Adil Shah Khoodoruth Maria Anayali Estudillo-Guerra Kevin Pacheco-Barrios Kevin Pacheco-Barrios Azan Nyundo Gina Chapa-Koloffon Sami Ouanes |
| author_facet | Mohamed Adil Shah Khoodoruth Maria Anayali Estudillo-Guerra Kevin Pacheco-Barrios Kevin Pacheco-Barrios Azan Nyundo Gina Chapa-Koloffon Sami Ouanes |
| author_sort | Mohamed Adil Shah Khoodoruth |
| collection | DOAJ |
| description | Depressive disorders are among the most common psychiatric conditions and contribute to significant morbidity. Even though the use of antidepressants revolutionized the management of depression and had a tremendous positive impact on the patient's outcome, a significant proportion of patients with major depressive disorder (MDD) show no or partial or response even with adequate treatment. Given the limitations of the prevailing monoamine hypothesis-based pharmacotherapy, glutamate and glutamatergic related pathways may offer an alternative and a complementary option for designing novel intervention strategies. Over the past few decades, there has been a growing interest in understanding the neurobiological underpinnings of glutamatergic dysfunctions in the pathogenesis of depressive disorders and the development of new pharmacological and non-pharmacological treatment options. There is a growing body of evidence for the efficacy of neuromodulation techniques, including transcranial magnetic stimulation, transcutaneous direct current stimulation, transcranial alternating current stimulation, and photo-biomodulation on improving connectivity and neuroplasticity associated with depression. This review attempts to revisit the role of glutamatergic neurotransmission in the etiopathogenesis of depressive disorders and review the current neuroimaging, neurophysiological and clinical evidence of these neuromodulation techniques in the pathophysiology and treatment of depression. |
| first_indexed | 2024-12-10T13:17:18Z |
| format | Article |
| id | doaj.art-406603f53e6549448c3a2c2bfbbbee7c |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-10T13:17:18Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-406603f53e6549448c3a2c2bfbbbee7c2022-12-22T01:47:29ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-04-011310.3389/fpsyt.2022.886918886918Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques OptimizationMohamed Adil Shah Khoodoruth0Maria Anayali Estudillo-Guerra1Kevin Pacheco-Barrios2Kevin Pacheco-Barrios3Azan Nyundo4Gina Chapa-Koloffon5Sami Ouanes6Department of Psychiatry, Hamad Medical Corporation, Doha, QatarDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, MA, United StatesNeuromodulation Center and Center for Clinical Research Learning, Harvard Medical School, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Boston, MA, United StatesUniversidad San Ignacio de Loyola, Vicerrectorado de Investigación, Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Lima, PeruDepartment of Psychiatry and Mental Health, School of Medicine and Dental Health, The University of Dodoma, Dodoma, TanzaniaHospital Infantil de México Federico Gómez, Mexico City, MexicoDepartment of Psychiatry, Hamad Medical Corporation, Doha, QatarDepressive disorders are among the most common psychiatric conditions and contribute to significant morbidity. Even though the use of antidepressants revolutionized the management of depression and had a tremendous positive impact on the patient's outcome, a significant proportion of patients with major depressive disorder (MDD) show no or partial or response even with adequate treatment. Given the limitations of the prevailing monoamine hypothesis-based pharmacotherapy, glutamate and glutamatergic related pathways may offer an alternative and a complementary option for designing novel intervention strategies. Over the past few decades, there has been a growing interest in understanding the neurobiological underpinnings of glutamatergic dysfunctions in the pathogenesis of depressive disorders and the development of new pharmacological and non-pharmacological treatment options. There is a growing body of evidence for the efficacy of neuromodulation techniques, including transcranial magnetic stimulation, transcutaneous direct current stimulation, transcranial alternating current stimulation, and photo-biomodulation on improving connectivity and neuroplasticity associated with depression. This review attempts to revisit the role of glutamatergic neurotransmission in the etiopathogenesis of depressive disorders and review the current neuroimaging, neurophysiological and clinical evidence of these neuromodulation techniques in the pathophysiology and treatment of depression.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.886918/fullglutamateneuromodulationTMS (repetitive transcranial magnetic stimulation)direct current stimulation (tDCS)photo-biomodulation therapytreatment-resistant depression |
| spellingShingle | Mohamed Adil Shah Khoodoruth Maria Anayali Estudillo-Guerra Kevin Pacheco-Barrios Kevin Pacheco-Barrios Azan Nyundo Gina Chapa-Koloffon Sami Ouanes Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization Frontiers in Psychiatry glutamate neuromodulation TMS (repetitive transcranial magnetic stimulation) direct current stimulation (tDCS) photo-biomodulation therapy treatment-resistant depression |
| title | Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization |
| title_full | Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization |
| title_fullStr | Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization |
| title_full_unstemmed | Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization |
| title_short | Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization |
| title_sort | glutamatergic system in depression and its role in neuromodulatory techniques optimization |
| topic | glutamate neuromodulation TMS (repetitive transcranial magnetic stimulation) direct current stimulation (tDCS) photo-biomodulation therapy treatment-resistant depression |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.886918/full |
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