Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies
Fungal infections have become a major health concern, given that invasive infections by <i>Candida, Cryptococcus,</i> and <i>Aspergillus</i> species have led to millions of mortalities. Conventional antifungal drugs including polyenes, echinocandins, azoles, allylamins, and a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/18/10104 |
| _version_ | 1797518804041859072 |
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| author | Wei Du Yiru Gao Li Liu Sixiang Sai Chen Ding |
| author_facet | Wei Du Yiru Gao Li Liu Sixiang Sai Chen Ding |
| author_sort | Wei Du |
| collection | DOAJ |
| description | Fungal infections have become a major health concern, given that invasive infections by <i>Candida, Cryptococcus,</i> and <i>Aspergillus</i> species have led to millions of mortalities. Conventional antifungal drugs including polyenes, echinocandins, azoles, allylamins, and antimetabolites have been used for decades, but their limitations include off-target toxicity, drug-resistance, poor water solubility, low bioavailability, and weak tissue penetration, which cannot be ignored. These drawbacks have led to the emergence of novel antifungal therapies. In this review, we discuss the nanosystems that are currently utilized for drug delivery and the application of antifungal therapies. |
| first_indexed | 2024-03-10T07:34:39Z |
| format | Article |
| id | doaj.art-406715e98262448ab94a924b56d602bb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T07:34:39Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-406715e98262448ab94a924b56d602bb2023-11-22T13:32:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-0122181010410.3390/ijms221810104Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal StrategiesWei Du0Yiru Gao1Li Liu2Sixiang Sai3Chen Ding4College of Life and Health Sciences, Northeastern University, Shenyang 110015, ChinaCollege of Life and Health Sciences, Northeastern University, Shenyang 110015, ChinaCollege of Life and Health Sciences, Northeastern University, Shenyang 110015, ChinaSchool of Medicine, Binzhou Medical University, Yantai 264003, ChinaCollege of Life and Health Sciences, Northeastern University, Shenyang 110015, ChinaFungal infections have become a major health concern, given that invasive infections by <i>Candida, Cryptococcus,</i> and <i>Aspergillus</i> species have led to millions of mortalities. Conventional antifungal drugs including polyenes, echinocandins, azoles, allylamins, and antimetabolites have been used for decades, but their limitations include off-target toxicity, drug-resistance, poor water solubility, low bioavailability, and weak tissue penetration, which cannot be ignored. These drawbacks have led to the emergence of novel antifungal therapies. In this review, we discuss the nanosystems that are currently utilized for drug delivery and the application of antifungal therapies.https://www.mdpi.com/1422-0067/22/18/10104fungal infectionantifungal therapiesnanosystems |
| spellingShingle | Wei Du Yiru Gao Li Liu Sixiang Sai Chen Ding Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies International Journal of Molecular Sciences fungal infection antifungal therapies nanosystems |
| title | Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies |
| title_full | Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies |
| title_fullStr | Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies |
| title_full_unstemmed | Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies |
| title_short | Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies |
| title_sort | striking back against fungal infections the utilization of nanosystems for antifungal strategies |
| topic | fungal infection antifungal therapies nanosystems |
| url | https://www.mdpi.com/1422-0067/22/18/10104 |
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