A day awake attenuates motor learning-induced increases in corticomotor excitability.
The ‘synaptic homeostasis hypothesis’ proposes that the brain’s capacity to exhibit synaptic plasticity is reduced during the day but restores when sleeping. While this prediction has been confirmed for declarative memories, it is currently unknown whether it is also the case for motor memories. We...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-03-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00138/full |
| _version_ | 1818319443660374016 |
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| author | Toon T de Beukelaar Jago eVan Soom Reto eHuber Nicole eWenderoth Nicole eWenderoth |
| author_facet | Toon T de Beukelaar Jago eVan Soom Reto eHuber Nicole eWenderoth Nicole eWenderoth |
| author_sort | Toon T de Beukelaar |
| collection | DOAJ |
| description | The ‘synaptic homeostasis hypothesis’ proposes that the brain’s capacity to exhibit synaptic plasticity is reduced during the day but restores when sleeping. While this prediction has been confirmed for declarative memories, it is currently unknown whether it is also the case for motor memories. We quantified practice-induced changes in corticomotor excitability in response to repetitive motor sequence training as an indirect marker of synaptic plasticity in the primary motor cortex. Subjects either practiced a motor sequence in the morning and a new motor sequence in the evening, i.e. after a 12h period of wakefulness (wake group); or they practiced a sequence in the evening and a new sequence in the morning, i.e. after a 12h period including sleep (sleep group). In both wake and sleep groups motor training improved movement performance irrespective of the time of day. Learning a new sequence in the morning triggered a clear increase in corticomotor excitability suggesting that motor training triggered synaptic adaptation in the primary motor cortex that was absent when a new sequence was learned in the evening. Thus, the magnitude of the practice-induced increase in corticomotor excitability was significantly influenced by time of day while the magnitude of motor performance improvements were not. These results suggest that the motor cortex’s potential to efficiently adapt to the environment by quickly adjusting synaptic strength in an activity-dependent manner is higher in the morning than in the evening. |
| first_indexed | 2024-12-13T10:09:12Z |
| format | Article |
| id | doaj.art-4069ed5a9f6c49659883720e4c12297b |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-13T10:09:12Z |
| publishDate | 2016-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-4069ed5a9f6c49659883720e4c12297b2022-12-21T23:51:28ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612016-03-011010.3389/fnhum.2016.00138174554A day awake attenuates motor learning-induced increases in corticomotor excitability.Toon T de Beukelaar0Jago eVan Soom1Reto eHuber2Nicole eWenderoth3Nicole eWenderoth4KU LeuvenKU LeuvenUniversity Children’s Hospital ZurichETH ZurichKU LeuvenThe ‘synaptic homeostasis hypothesis’ proposes that the brain’s capacity to exhibit synaptic plasticity is reduced during the day but restores when sleeping. While this prediction has been confirmed for declarative memories, it is currently unknown whether it is also the case for motor memories. We quantified practice-induced changes in corticomotor excitability in response to repetitive motor sequence training as an indirect marker of synaptic plasticity in the primary motor cortex. Subjects either practiced a motor sequence in the morning and a new motor sequence in the evening, i.e. after a 12h period of wakefulness (wake group); or they practiced a sequence in the evening and a new sequence in the morning, i.e. after a 12h period including sleep (sleep group). In both wake and sleep groups motor training improved movement performance irrespective of the time of day. Learning a new sequence in the morning triggered a clear increase in corticomotor excitability suggesting that motor training triggered synaptic adaptation in the primary motor cortex that was absent when a new sequence was learned in the evening. Thus, the magnitude of the practice-induced increase in corticomotor excitability was significantly influenced by time of day while the magnitude of motor performance improvements were not. These results suggest that the motor cortex’s potential to efficiently adapt to the environment by quickly adjusting synaptic strength in an activity-dependent manner is higher in the morning than in the evening.http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00138/fullSleepTranscranial Magnetic Stimulationmotor learningSynaptic homeostasis hypothesisfinger sequence tapping |
| spellingShingle | Toon T de Beukelaar Jago eVan Soom Reto eHuber Nicole eWenderoth Nicole eWenderoth A day awake attenuates motor learning-induced increases in corticomotor excitability. Frontiers in Human Neuroscience Sleep Transcranial Magnetic Stimulation motor learning Synaptic homeostasis hypothesis finger sequence tapping |
| title | A day awake attenuates motor learning-induced increases in corticomotor excitability. |
| title_full | A day awake attenuates motor learning-induced increases in corticomotor excitability. |
| title_fullStr | A day awake attenuates motor learning-induced increases in corticomotor excitability. |
| title_full_unstemmed | A day awake attenuates motor learning-induced increases in corticomotor excitability. |
| title_short | A day awake attenuates motor learning-induced increases in corticomotor excitability. |
| title_sort | day awake attenuates motor learning induced increases in corticomotor excitability |
| topic | Sleep Transcranial Magnetic Stimulation motor learning Synaptic homeostasis hypothesis finger sequence tapping |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00138/full |
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