Discontinuation of rLH two days before hCG may increase the number of oocytes retrieved in IVF
<p>Abstract</p> <p>Background</p> <p>Administration of recombinant luteinizing hormone (rLH) in controlled ovarian hyperstimulation may benefit a subpopulation of patients. However, late follicular phase administration of high doses of rLH may also reduce the size of th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-03-01
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| Series: | Reproductive Biology and Endocrinology |
| Online Access: | http://www.rbej.com/content/8/1/29 |
| _version_ | 1818750035094929408 |
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| author | Session Donna R Copland Susannah D Browne Aimee S Spencer Jessica B |
| author_facet | Session Donna R Copland Susannah D Browne Aimee S Spencer Jessica B |
| author_sort | Session Donna R |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Administration of recombinant luteinizing hormone (rLH) in controlled ovarian hyperstimulation may benefit a subpopulation of patients. However, late follicular phase administration of high doses of rLH may also reduce the size of the follicular cohort and promote monofollicular development.</p> <p>Methods</p> <p>To determine if rLH in late follicular development had a negative impact on follicular growth and oocyte yield, IVF patients in our practice who received rFSH and rLH for the entire stimulation were retrospectively compared with those that had the rLH discontinued at least two days prior to hCG trigger.</p> <p>Results</p> <p>The two groups had similar baseline characteristics before stimulation with respect to age, FSH level and antral follicle count. However, the group which had the rLH discontinued at least two days prior to their hCG shot, had a significantly higher number of oocytes retrieved, including a higher number of MII oocytes and number of 2PN embryos.</p> <p>Conclusions</p> <p>When using rLH for controlled ovarian hyperstimulation, administering it from the start of stimulation and stopping it in the late follicular phase, at least two days prior to hCG trigger, may increase oocyte and embryo yield.</p> |
| first_indexed | 2024-12-18T04:13:16Z |
| format | Article |
| id | doaj.art-406a7bb362d746179c93e2fdb401c4de |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-12-18T04:13:16Z |
| publishDate | 2010-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-406a7bb362d746179c93e2fdb401c4de2022-12-21T21:21:26ZengBMCReproductive Biology and Endocrinology1477-78272010-03-01812910.1186/1477-7827-8-29Discontinuation of rLH two days before hCG may increase the number of oocytes retrieved in IVFSession Donna RCopland Susannah DBrowne Aimee SSpencer Jessica B<p>Abstract</p> <p>Background</p> <p>Administration of recombinant luteinizing hormone (rLH) in controlled ovarian hyperstimulation may benefit a subpopulation of patients. However, late follicular phase administration of high doses of rLH may also reduce the size of the follicular cohort and promote monofollicular development.</p> <p>Methods</p> <p>To determine if rLH in late follicular development had a negative impact on follicular growth and oocyte yield, IVF patients in our practice who received rFSH and rLH for the entire stimulation were retrospectively compared with those that had the rLH discontinued at least two days prior to hCG trigger.</p> <p>Results</p> <p>The two groups had similar baseline characteristics before stimulation with respect to age, FSH level and antral follicle count. However, the group which had the rLH discontinued at least two days prior to their hCG shot, had a significantly higher number of oocytes retrieved, including a higher number of MII oocytes and number of 2PN embryos.</p> <p>Conclusions</p> <p>When using rLH for controlled ovarian hyperstimulation, administering it from the start of stimulation and stopping it in the late follicular phase, at least two days prior to hCG trigger, may increase oocyte and embryo yield.</p>http://www.rbej.com/content/8/1/29 |
| spellingShingle | Session Donna R Copland Susannah D Browne Aimee S Spencer Jessica B Discontinuation of rLH two days before hCG may increase the number of oocytes retrieved in IVF Reproductive Biology and Endocrinology |
| title | Discontinuation of rLH two days before hCG may increase the number of oocytes retrieved in IVF |
| title_full | Discontinuation of rLH two days before hCG may increase the number of oocytes retrieved in IVF |
| title_fullStr | Discontinuation of rLH two days before hCG may increase the number of oocytes retrieved in IVF |
| title_full_unstemmed | Discontinuation of rLH two days before hCG may increase the number of oocytes retrieved in IVF |
| title_short | Discontinuation of rLH two days before hCG may increase the number of oocytes retrieved in IVF |
| title_sort | discontinuation of rlh two days before hcg may increase the number of oocytes retrieved in ivf |
| url | http://www.rbej.com/content/8/1/29 |
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