Muscle and Systemic Molecular Responses to a Single Flywheel Based Iso-Inertial Training Session in Resistance-Trained Men
Growing evidence points to the effectiveness of flywheel (FW) based iso-inertial resistance training in improving physical performance capacities. However, molecular adaptations induced by FW exercises are largely unknown. Eight resistance-trained men performed 5 sets of 10 maximal squats on a FW de...
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Frontiers Media S.A.
2019-05-01
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Series: | Frontiers in Physiology |
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Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.00554/full |
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author | Giosuè Annibalini Serena Contarelli Francesco Lucertini Michele Guescini Serena Maggio Paola Ceccaroli Marco Gervasi Carlo Ferri Marini Francesco Fardetti Eugenio Grassi Vilberto Stocchi Elena Barbieri Elena Barbieri Piero Benelli |
author_facet | Giosuè Annibalini Serena Contarelli Francesco Lucertini Michele Guescini Serena Maggio Paola Ceccaroli Marco Gervasi Carlo Ferri Marini Francesco Fardetti Eugenio Grassi Vilberto Stocchi Elena Barbieri Elena Barbieri Piero Benelli |
author_sort | Giosuè Annibalini |
collection | DOAJ |
description | Growing evidence points to the effectiveness of flywheel (FW) based iso-inertial resistance training in improving physical performance capacities. However, molecular adaptations induced by FW exercises are largely unknown. Eight resistance-trained men performed 5 sets of 10 maximal squats on a FW device. Muscle biopsies (fine needle aspiration technique) and blood samples were collected before (t0), and 2 h (t1) after FW exercise. Blood samples were additionally drawn after 24 h (t2) and 48 h (t3). Paired samples t-tests revealed significant increases, at t1, of mRNA expression of the genes involved in inflammation, in both muscle (MCP-1, TNF-α, IL-6) and peripheral blood mononuclear cells (IkB-α, MCP-1). Circulating extracellular vesicles (EVs) and EV-encapsulated miRNA levels (miR-206, miR-146a) significantly increased at t1 as well. Conversely, muscle mRNA level of genes associated with muscle growth/remodeling (IGF-1Ea, cyclin D1, myogenin) decreased at t1. One-way repeated measure ANOVAs, with Bonferroni corrected post-hoc pairwise comparisons, revealed significant increases in plasma concentrations of IL-6 (t1; t2; t3) and muscle creatine kinase (t1; t2), while IGF-1 significantly increased at t2 only. Our findings show that, even in experienced resistance trained individuals, a single FW training session modifies local and systemic markers involved in late structural remodeling and functional adaptation of skeletal muscle. |
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last_indexed | 2024-04-12T05:16:47Z |
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spelling | doaj.art-406a8aad72f84768a8f29c6237ab09ee2022-12-22T03:46:36ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-05-011010.3389/fphys.2019.00554450747Muscle and Systemic Molecular Responses to a Single Flywheel Based Iso-Inertial Training Session in Resistance-Trained MenGiosuè Annibalini0Serena Contarelli1Francesco Lucertini2Michele Guescini3Serena Maggio4Paola Ceccaroli5Marco Gervasi6Carlo Ferri Marini7Francesco Fardetti8Eugenio Grassi9Vilberto Stocchi10Elena Barbieri11Elena Barbieri12Piero Benelli13Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Urbino, ItalyDepartment of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Urbino, ItalyDepartment of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Urbino, ItalyDepartment of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Urbino, ItalyDepartment of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Urbino, ItalyDepartment of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Urbino, ItalyDepartment of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Urbino, ItalyDepartment of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Urbino, ItalyDepartment of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Urbino, ItalyDepartment of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Urbino, ItalyDepartment of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Urbino, ItalyDepartment of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Urbino, ItalyInteruniversity Institute of Myology, Urbino, ItalyDepartment of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Urbino, ItalyGrowing evidence points to the effectiveness of flywheel (FW) based iso-inertial resistance training in improving physical performance capacities. However, molecular adaptations induced by FW exercises are largely unknown. Eight resistance-trained men performed 5 sets of 10 maximal squats on a FW device. Muscle biopsies (fine needle aspiration technique) and blood samples were collected before (t0), and 2 h (t1) after FW exercise. Blood samples were additionally drawn after 24 h (t2) and 48 h (t3). Paired samples t-tests revealed significant increases, at t1, of mRNA expression of the genes involved in inflammation, in both muscle (MCP-1, TNF-α, IL-6) and peripheral blood mononuclear cells (IkB-α, MCP-1). Circulating extracellular vesicles (EVs) and EV-encapsulated miRNA levels (miR-206, miR-146a) significantly increased at t1 as well. Conversely, muscle mRNA level of genes associated with muscle growth/remodeling (IGF-1Ea, cyclin D1, myogenin) decreased at t1. One-way repeated measure ANOVAs, with Bonferroni corrected post-hoc pairwise comparisons, revealed significant increases in plasma concentrations of IL-6 (t1; t2; t3) and muscle creatine kinase (t1; t2), while IGF-1 significantly increased at t2 only. Our findings show that, even in experienced resistance trained individuals, a single FW training session modifies local and systemic markers involved in late structural remodeling and functional adaptation of skeletal muscle.https://www.frontiersin.org/article/10.3389/fphys.2019.00554/fulliso-inertial exerciseinflammationgrowth factorsextracellular vesiclescirculating miRNAs |
spellingShingle | Giosuè Annibalini Serena Contarelli Francesco Lucertini Michele Guescini Serena Maggio Paola Ceccaroli Marco Gervasi Carlo Ferri Marini Francesco Fardetti Eugenio Grassi Vilberto Stocchi Elena Barbieri Elena Barbieri Piero Benelli Muscle and Systemic Molecular Responses to a Single Flywheel Based Iso-Inertial Training Session in Resistance-Trained Men Frontiers in Physiology iso-inertial exercise inflammation growth factors extracellular vesicles circulating miRNAs |
title | Muscle and Systemic Molecular Responses to a Single Flywheel Based Iso-Inertial Training Session in Resistance-Trained Men |
title_full | Muscle and Systemic Molecular Responses to a Single Flywheel Based Iso-Inertial Training Session in Resistance-Trained Men |
title_fullStr | Muscle and Systemic Molecular Responses to a Single Flywheel Based Iso-Inertial Training Session in Resistance-Trained Men |
title_full_unstemmed | Muscle and Systemic Molecular Responses to a Single Flywheel Based Iso-Inertial Training Session in Resistance-Trained Men |
title_short | Muscle and Systemic Molecular Responses to a Single Flywheel Based Iso-Inertial Training Session in Resistance-Trained Men |
title_sort | muscle and systemic molecular responses to a single flywheel based iso inertial training session in resistance trained men |
topic | iso-inertial exercise inflammation growth factors extracellular vesicles circulating miRNAs |
url | https://www.frontiersin.org/article/10.3389/fphys.2019.00554/full |
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