Advances in exercise-induced vascular adaptation: mechanisms, models, and methods
Insufficient physical activity poses a significant risk factor for cardiovascular diseases. Exercise plays a crucial role in influencing the vascular system and is essential for maintaining vascular health. Hemodynamic stimuli generated by exercise, such as shear stress and circumferential stress, d...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1370234/full |
| _version_ | 1797300281504956416 |
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| author | Hualing Sun Yanyan Zhang Yanyan Zhang Yanyan Zhang Lijun Shi Lijun Shi Lijun Shi |
| author_facet | Hualing Sun Yanyan Zhang Yanyan Zhang Yanyan Zhang Lijun Shi Lijun Shi Lijun Shi |
| author_sort | Hualing Sun |
| collection | DOAJ |
| description | Insufficient physical activity poses a significant risk factor for cardiovascular diseases. Exercise plays a crucial role in influencing the vascular system and is essential for maintaining vascular health. Hemodynamic stimuli generated by exercise, such as shear stress and circumferential stress, directly impact vascular structure and function, resulting in adaptive changes. In clinical settings, incorporating appropriate exercise interventions has become a powerful supplementary approach for treating and rehabilitating various cardiovascular conditions. However, existing models for studying exercise-induced vascular adaptation primarily rely on in vivo animal and in vitro cellular models, each with its inherent limitations. In contrast, human research faces challenges in conducting mechanistic analyses due to ethics issues. Therefore, it is imperative to develop highly biomimetic in vitro/ex vivo vascular models that can replicate exercise stimuli in human systems. Utilizing various vascular assessment techniques is also crucial to comprehensively evaluate the effects of exercise on the vasculature and uncover the molecular mechanisms that promote vascular health. This article reviews the hemodynamic mechanisms that underlie exercise-induced vascular adaptation. It explores the advancements in current vascular models and measurement techniques, while addressing their future development and challenges. The overarching goal is to unravel the molecular mechanisms that drive the positive effects of exercise on the cardiovascular system. By providing a scientific rationale and offering novel perspectives, the aim is to contribute to the formulation of precise cardiovascular rehabilitation exercise prescriptions. |
| first_indexed | 2024-03-07T23:04:58Z |
| format | Article |
| id | doaj.art-406bcbb2d82c43d68bdaeb14c751eda9 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-07T23:04:58Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-406bcbb2d82c43d68bdaeb14c751eda92024-02-22T05:19:24ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-02-011210.3389/fbioe.2024.13702341370234Advances in exercise-induced vascular adaptation: mechanisms, models, and methodsHualing Sun0Yanyan Zhang1Yanyan Zhang2Yanyan Zhang3Lijun Shi4Lijun Shi5Lijun Shi6Department of Exercise Physiology, Beijing Sport University, Beijing, ChinaDepartment of Exercise Physiology, Beijing Sport University, Beijing, ChinaLaboratory of Sports Stress and Adaptation of General Administration of Sport, Beijing Sport University, Beijing, ChinaKey Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing, ChinaDepartment of Exercise Physiology, Beijing Sport University, Beijing, ChinaLaboratory of Sports Stress and Adaptation of General Administration of Sport, Beijing Sport University, Beijing, ChinaKey Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing, ChinaInsufficient physical activity poses a significant risk factor for cardiovascular diseases. Exercise plays a crucial role in influencing the vascular system and is essential for maintaining vascular health. Hemodynamic stimuli generated by exercise, such as shear stress and circumferential stress, directly impact vascular structure and function, resulting in adaptive changes. In clinical settings, incorporating appropriate exercise interventions has become a powerful supplementary approach for treating and rehabilitating various cardiovascular conditions. However, existing models for studying exercise-induced vascular adaptation primarily rely on in vivo animal and in vitro cellular models, each with its inherent limitations. In contrast, human research faces challenges in conducting mechanistic analyses due to ethics issues. Therefore, it is imperative to develop highly biomimetic in vitro/ex vivo vascular models that can replicate exercise stimuli in human systems. Utilizing various vascular assessment techniques is also crucial to comprehensively evaluate the effects of exercise on the vasculature and uncover the molecular mechanisms that promote vascular health. This article reviews the hemodynamic mechanisms that underlie exercise-induced vascular adaptation. It explores the advancements in current vascular models and measurement techniques, while addressing their future development and challenges. The overarching goal is to unravel the molecular mechanisms that drive the positive effects of exercise on the cardiovascular system. By providing a scientific rationale and offering novel perspectives, the aim is to contribute to the formulation of precise cardiovascular rehabilitation exercise prescriptions.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1370234/fullexercisevascular adaptationhemodynamic stimuliin vitro vascular modelex vivo vascular model |
| spellingShingle | Hualing Sun Yanyan Zhang Yanyan Zhang Yanyan Zhang Lijun Shi Lijun Shi Lijun Shi Advances in exercise-induced vascular adaptation: mechanisms, models, and methods Frontiers in Bioengineering and Biotechnology exercise vascular adaptation hemodynamic stimuli in vitro vascular model ex vivo vascular model |
| title | Advances in exercise-induced vascular adaptation: mechanisms, models, and methods |
| title_full | Advances in exercise-induced vascular adaptation: mechanisms, models, and methods |
| title_fullStr | Advances in exercise-induced vascular adaptation: mechanisms, models, and methods |
| title_full_unstemmed | Advances in exercise-induced vascular adaptation: mechanisms, models, and methods |
| title_short | Advances in exercise-induced vascular adaptation: mechanisms, models, and methods |
| title_sort | advances in exercise induced vascular adaptation mechanisms models and methods |
| topic | exercise vascular adaptation hemodynamic stimuli in vitro vascular model ex vivo vascular model |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1370234/full |
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