Hormesis: Wound healing and keratinocytes
Hormetic dose responses (i.e., a biphasic dose/concentration response characterized by a low dose stimulation and a high dose inhibition) are shown herein to be commonly reported in the dermal wound healing process, with the particular focus on cell viability, proliferation, and migration of human k...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661822003383 |
| _version_ | 1797366578127306752 |
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| author | Edward J. Calabrese Gaurav Dhawan Rachna Kapoor Evgenios Agathokleous Vittorio Calabrese |
| author_facet | Edward J. Calabrese Gaurav Dhawan Rachna Kapoor Evgenios Agathokleous Vittorio Calabrese |
| author_sort | Edward J. Calabrese |
| collection | DOAJ |
| description | Hormetic dose responses (i.e., a biphasic dose/concentration response characterized by a low dose stimulation and a high dose inhibition) are shown herein to be commonly reported in the dermal wound healing process, with the particular focus on cell viability, proliferation, and migration of human keratinocytes in in vitro studies. Hormetic responses are induced by a wide range of substances, including endogenous agents, numerous drug and nanoparticle preparations and especially plant derived extracts, including many well-known dietary supplements as well as physical stressor agents, such as low-level laser treatments. Detailed mechanistic studies have identified common signaling pathways and their cross-pathway communications that mediate the hormetic dose responses. These findings suggest that the concept of hormesis plays a fundamental role in wound healing, with important potential implications for agent screening and evaluation, as well as clinical strategies. |
| first_indexed | 2024-03-08T17:06:43Z |
| format | Article |
| id | doaj.art-406cc095c71b4e25a9e25a82fa36a4bb |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-08T17:06:43Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-406cc095c71b4e25a9e25a82fa36a4bb2024-01-04T04:38:14ZengElsevierPharmacological Research1096-11862022-09-01183106393Hormesis: Wound healing and keratinocytesEdward J. Calabrese0Gaurav Dhawan1Rachna Kapoor2Evgenios Agathokleous3Vittorio Calabrese4Professor of Toxicology; School of Public Health and Health Sciences, Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003 USA; Corresponding author.Sri Guru Ram Das (SGRD); University of Health Sciences, Amritsar, IndiaSaint Francis Hospital and Medical Center; Hartford, CT, USASchool of Applied Meteorology; Nanjing University of Information Science & Technology; Nanjing 210044, ChinaDepartment of Biomedical and Biotechnological Sciences, School of Medicine University of Catania, Via Santa Sofia 97, Catania 95123, ItalyHormetic dose responses (i.e., a biphasic dose/concentration response characterized by a low dose stimulation and a high dose inhibition) are shown herein to be commonly reported in the dermal wound healing process, with the particular focus on cell viability, proliferation, and migration of human keratinocytes in in vitro studies. Hormetic responses are induced by a wide range of substances, including endogenous agents, numerous drug and nanoparticle preparations and especially plant derived extracts, including many well-known dietary supplements as well as physical stressor agents, such as low-level laser treatments. Detailed mechanistic studies have identified common signaling pathways and their cross-pathway communications that mediate the hormetic dose responses. These findings suggest that the concept of hormesis plays a fundamental role in wound healing, with important potential implications for agent screening and evaluation, as well as clinical strategies.http://www.sciencedirect.com/science/article/pii/S1043661822003383HormesisWound healingPhytochemicalsHaCaT cellsBiphasic dose responseKeratinocytes |
| spellingShingle | Edward J. Calabrese Gaurav Dhawan Rachna Kapoor Evgenios Agathokleous Vittorio Calabrese Hormesis: Wound healing and keratinocytes Pharmacological Research Hormesis Wound healing Phytochemicals HaCaT cells Biphasic dose response Keratinocytes |
| title | Hormesis: Wound healing and keratinocytes |
| title_full | Hormesis: Wound healing and keratinocytes |
| title_fullStr | Hormesis: Wound healing and keratinocytes |
| title_full_unstemmed | Hormesis: Wound healing and keratinocytes |
| title_short | Hormesis: Wound healing and keratinocytes |
| title_sort | hormesis wound healing and keratinocytes |
| topic | Hormesis Wound healing Phytochemicals HaCaT cells Biphasic dose response Keratinocytes |
| url | http://www.sciencedirect.com/science/article/pii/S1043661822003383 |
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