TLR4 sensing of IsdB of Staphylococcus aureus induces a proinflammatory cytokine response via the NLRP3-caspase-1 inflammasome cascade

TLR4 sensing of IsdB of Staphylococcus aureus induces a proinflammatory cytokine response via the NLRP3-caspase-1 inflammasome cascade

ABSTRACTThe iron-regulated surface determinant protein B (IsdB) of Staphylococcus aureus is involved in the acquisition of iron from hemoglobin. Moreover, IsdB elicits an adaptive immune response in mice and humans. Here, we show that IsdB also has impact on innate immunity. IsdB induces the release...

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Bibliographic Details
Main Authors: Juan José Izquierdo Gonzalez, Md Faruq Hossain, Jolanda Neef, Erin E. Zwack, Chih-Ming Tsai, Dina Raafat, Kevin Fechtner, Luise Herzog, Thomas P. Kohler, Rabea Schlüter, Alexander Reder, Silva Holtfreter, George Y. Liu, Sven Hammerschmidt, Uwe Völker, Victor J. Torres, Jan Maarten van Dijl, Christopher H. Lillig, Barbara M. Bröker, Murty N. Darisipudi
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:mBio
Subjects:
cytokines
innate immunity
IsdB
Staphylococcus aureus
TLR4
NLRP3 inflammasome
Online Access:https://journals.asm.org/doi/10.1128/mbio.00225-23

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