Primary hyperparathyroidism having multiple Brown tumors mimicking malignancy

Primary hyperparathyroidism is a disease characterized by excessive secretion of parathormone. During the course of this disease, bone loss occurs, particularly depending on resorption of the skeletal system. One of the complications of primary hyperparathyroidism is fibrotic, cystic bony changes wh...

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Main Authors: Ekram Ullah, Mehtab Ahmad, Syed Asmat Ali, Navneet Redhu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2012-01-01
Series:Indian Journal of Endocrinology and Metabolism
Subjects:
Online Access:http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=6;spage=1040;epage=1042;aulast=Ullah
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author Ekram Ullah
Mehtab Ahmad
Syed Asmat Ali
Navneet Redhu
author_facet Ekram Ullah
Mehtab Ahmad
Syed Asmat Ali
Navneet Redhu
author_sort Ekram Ullah
collection DOAJ
description Primary hyperparathyroidism is a disease characterized by excessive secretion of parathormone. During the course of this disease, bone loss occurs, particularly depending on resorption of the skeletal system. One of the complications of primary hyperparathyroidism is fibrotic, cystic bony changes which is called Brown tumor. Skeletal manifestations in the form of Brown tumors are rare and according to literature occur in less than 2% of patients suffering from any form of hyperparathyroidism. Such rare and multiple benign lesions may simulate a malignant neoplasm and pose a real challenge for the clinician in its differential diagnosis. We present a case of a 23-year-old Indian woman who was evaluated for multiple lytic expansile lesions with a strong suspicion of malignancy and fibrous dysplasia but turned out to be a case of primary hyperparathyroidism.
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spelling doaj.art-407145db82434f8c92be4a037ac854052022-12-22T01:00:28ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002012-01-011661040104210.4103/2230-8210.103037Primary hyperparathyroidism having multiple Brown tumors mimicking malignancyEkram UllahMehtab AhmadSyed Asmat AliNavneet RedhuPrimary hyperparathyroidism is a disease characterized by excessive secretion of parathormone. During the course of this disease, bone loss occurs, particularly depending on resorption of the skeletal system. One of the complications of primary hyperparathyroidism is fibrotic, cystic bony changes which is called Brown tumor. Skeletal manifestations in the form of Brown tumors are rare and according to literature occur in less than 2% of patients suffering from any form of hyperparathyroidism. Such rare and multiple benign lesions may simulate a malignant neoplasm and pose a real challenge for the clinician in its differential diagnosis. We present a case of a 23-year-old Indian woman who was evaluated for multiple lytic expansile lesions with a strong suspicion of malignancy and fibrous dysplasia but turned out to be a case of primary hyperparathyroidism.http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=6;spage=1040;epage=1042;aulast=UllahBrown tumorsendocrine systemexpansile lesionsprimary hyperparathyroidism
spellingShingle Ekram Ullah
Mehtab Ahmad
Syed Asmat Ali
Navneet Redhu
Primary hyperparathyroidism having multiple Brown tumors mimicking malignancy
Indian Journal of Endocrinology and Metabolism
Brown tumors
endocrine system
expansile lesions
primary hyperparathyroidism
title Primary hyperparathyroidism having multiple Brown tumors mimicking malignancy
title_full Primary hyperparathyroidism having multiple Brown tumors mimicking malignancy
title_fullStr Primary hyperparathyroidism having multiple Brown tumors mimicking malignancy
title_full_unstemmed Primary hyperparathyroidism having multiple Brown tumors mimicking malignancy
title_short Primary hyperparathyroidism having multiple Brown tumors mimicking malignancy
title_sort primary hyperparathyroidism having multiple brown tumors mimicking malignancy
topic Brown tumors
endocrine system
expansile lesions
primary hyperparathyroidism
url http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=6;spage=1040;epage=1042;aulast=Ullah
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AT syedasmatali primaryhyperparathyroidismhavingmultiplebrowntumorsmimickingmalignancy
AT navneetredhu primaryhyperparathyroidismhavingmultiplebrowntumorsmimickingmalignancy