Systemic lupus erythematosus is associated with increased risk of Parkinson’s disease
Background: A small number of studies have suggested an association between systemic lupus erythematosus (SLE) and Parkinson’s disease (PD). Objectives: This study aimed to determine the risk of incident PD among Korean patients with SLE. Design: A nationwide retrospective cohort study using the cla...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-02-01
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| Series: | Therapeutic Advances in Musculoskeletal Disease |
| Online Access: | https://doi.org/10.1177/1759720X231152653 |
| _version_ | 1811164975343861760 |
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| author | In Young Kim Yeonghee Eun Jaejoon Lee Kyungdo Han Da Hye Kim Ju-Hong Min Hoon-Suk Cha Eun-Mi Koh Dong Wook Shin Hyungjin Kim |
| author_facet | In Young Kim Yeonghee Eun Jaejoon Lee Kyungdo Han Da Hye Kim Ju-Hong Min Hoon-Suk Cha Eun-Mi Koh Dong Wook Shin Hyungjin Kim |
| author_sort | In Young Kim |
| collection | DOAJ |
| description | Background: A small number of studies have suggested an association between systemic lupus erythematosus (SLE) and Parkinson’s disease (PD). Objectives: This study aimed to determine the risk of incident PD among Korean patients with SLE. Design: A nationwide retrospective cohort study using the claims database of the National Health Insurance Service of Korea was conducted. Methods: Patients above 40 years of age diagnosed with SLE between 2010 and 2015 were included in the study. The primary outcome of the study was incident PD, defined by registration in the rare intractable diseases program for PD and an ICD-10 code of G20. Subjects were followed until PD diagnosis or the end of 2017. We estimated the cumulative incidence of PD among the SLE cohort and compared this to that in a 1:5 age- and sex-matched control group. Results: Totals of 11,615 SLE cases and 58,075 matched controls were identified. The cumulative incidence rate of PD was 0.7 per 1000 person-years in the SLE cohort. The crude hazard ratio (HR) of incident PD was 1.71 (95% CI: 1.25–2.36) among the SLE cohort compared to the control group. The HR was 1.59 (95% CI: 1.15–2.20) after adjustment for age, sex, income, and baseline comorbidities. Conclusion: This study demonstrated that patients with SLE had an increased risk of incident PD compared to non-SLE controls. Further research is required to determine the mechanism underlying this and to elucidate the precise role of systemic inflammation in the development of PD in patients with SLE. |
| first_indexed | 2024-04-10T15:31:06Z |
| format | Article |
| id | doaj.art-407197175c7445e0a1cbfbcc480df62d |
| institution | Directory Open Access Journal |
| issn | 1759-7218 |
| language | English |
| last_indexed | 2024-04-10T15:31:06Z |
| publishDate | 2023-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Musculoskeletal Disease |
| spelling | doaj.art-407197175c7445e0a1cbfbcc480df62d2023-02-13T19:03:22ZengSAGE PublishingTherapeutic Advances in Musculoskeletal Disease1759-72182023-02-011510.1177/1759720X231152653Systemic lupus erythematosus is associated with increased risk of Parkinson’s diseaseIn Young KimYeonghee EunJaejoon LeeKyungdo HanDa Hye KimJu-Hong MinHoon-Suk ChaEun-Mi KohDong Wook ShinHyungjin KimBackground: A small number of studies have suggested an association between systemic lupus erythematosus (SLE) and Parkinson’s disease (PD). Objectives: This study aimed to determine the risk of incident PD among Korean patients with SLE. Design: A nationwide retrospective cohort study using the claims database of the National Health Insurance Service of Korea was conducted. Methods: Patients above 40 years of age diagnosed with SLE between 2010 and 2015 were included in the study. The primary outcome of the study was incident PD, defined by registration in the rare intractable diseases program for PD and an ICD-10 code of G20. Subjects were followed until PD diagnosis or the end of 2017. We estimated the cumulative incidence of PD among the SLE cohort and compared this to that in a 1:5 age- and sex-matched control group. Results: Totals of 11,615 SLE cases and 58,075 matched controls were identified. The cumulative incidence rate of PD was 0.7 per 1000 person-years in the SLE cohort. The crude hazard ratio (HR) of incident PD was 1.71 (95% CI: 1.25–2.36) among the SLE cohort compared to the control group. The HR was 1.59 (95% CI: 1.15–2.20) after adjustment for age, sex, income, and baseline comorbidities. Conclusion: This study demonstrated that patients with SLE had an increased risk of incident PD compared to non-SLE controls. Further research is required to determine the mechanism underlying this and to elucidate the precise role of systemic inflammation in the development of PD in patients with SLE.https://doi.org/10.1177/1759720X231152653 |
| spellingShingle | In Young Kim Yeonghee Eun Jaejoon Lee Kyungdo Han Da Hye Kim Ju-Hong Min Hoon-Suk Cha Eun-Mi Koh Dong Wook Shin Hyungjin Kim Systemic lupus erythematosus is associated with increased risk of Parkinson’s disease Therapeutic Advances in Musculoskeletal Disease |
| title | Systemic lupus erythematosus is associated with increased risk of Parkinson’s disease |
| title_full | Systemic lupus erythematosus is associated with increased risk of Parkinson’s disease |
| title_fullStr | Systemic lupus erythematosus is associated with increased risk of Parkinson’s disease |
| title_full_unstemmed | Systemic lupus erythematosus is associated with increased risk of Parkinson’s disease |
| title_short | Systemic lupus erythematosus is associated with increased risk of Parkinson’s disease |
| title_sort | systemic lupus erythematosus is associated with increased risk of parkinson s disease |
| url | https://doi.org/10.1177/1759720X231152653 |
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