CEP128 is involved in spermatogenesis in humans and mice
CEP128 is a centrosomal protein important for the organization of centriolar microtubules. Here, the authors show that a CEP128 variant observed in human male siblings causes reduced sperm counts and morphologically abnormal sperm when modeled in mice, suggesting a role for CEP128 in male fertility.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29109-7 |
| _version_ | 1818353474602008576 |
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| author | Xueguang Zhang Lingbo Wang Yongyi Ma Yan Wang Hongqian Liu Mohan Liu Lang Qin Jinghong Li Chuan Jiang Xiaojian Zhang Xudong Shan Yuliang Liu Jinsong Li Yaqian Li Rui Zheng Yongkang Sun Jianfeng Sun Xiangyou Leng Yan Liang Feng Zhang Xiaohui Jiang Yihong Yang Ying Shen |
| author_facet | Xueguang Zhang Lingbo Wang Yongyi Ma Yan Wang Hongqian Liu Mohan Liu Lang Qin Jinghong Li Chuan Jiang Xiaojian Zhang Xudong Shan Yuliang Liu Jinsong Li Yaqian Li Rui Zheng Yongkang Sun Jianfeng Sun Xiangyou Leng Yan Liang Feng Zhang Xiaohui Jiang Yihong Yang Ying Shen |
| author_sort | Xueguang Zhang |
| collection | DOAJ |
| description | CEP128 is a centrosomal protein important for the organization of centriolar microtubules. Here, the authors show that a CEP128 variant observed in human male siblings causes reduced sperm counts and morphologically abnormal sperm when modeled in mice, suggesting a role for CEP128 in male fertility. |
| first_indexed | 2024-12-13T19:10:06Z |
| format | Article |
| id | doaj.art-4071e25e045543c5be11198209b186bd |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T19:10:06Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4071e25e045543c5be11198209b186bd2022-12-21T23:34:26ZengNature PortfolioNature Communications2041-17232022-03-0113111710.1038/s41467-022-29109-7CEP128 is involved in spermatogenesis in humans and miceXueguang Zhang0Lingbo Wang1Yongyi Ma2Yan Wang3Hongqian Liu4Mohan Liu5Lang Qin6Jinghong Li7Chuan Jiang8Xiaojian Zhang9Xudong Shan10Yuliang Liu11Jinsong Li12Yaqian Li13Rui Zheng14Yongkang Sun15Jianfeng Sun16Xiangyou Leng17Yan Liang18Feng Zhang19Xiaohui Jiang20Yihong Yang21Ying Shen22Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityShanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Institute of Reproduction and Development, Obstetrics and Gynecology Hospital of Fudan UniversityDepartment of Gynecology and Obstetrics, Southwest Hospital, Third Military Medical University (Army Medical University)Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversitySichuan Academy of Medical Sciences of Sichuan Provincial People’s HospitalWest China School of Basic Medical Sciences and Forensic MedicineChengdu Research Base of Giant Panda BreedingCAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityTeaching Hospital of Chengdu University of TCMDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityResearch Core Facility of West China Hospital, Sichuan UniversityShanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Institute of Reproduction and Development, Obstetrics and Gynecology Hospital of Fudan UniversityDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan UniversityCEP128 is a centrosomal protein important for the organization of centriolar microtubules. Here, the authors show that a CEP128 variant observed in human male siblings causes reduced sperm counts and morphologically abnormal sperm when modeled in mice, suggesting a role for CEP128 in male fertility.https://doi.org/10.1038/s41467-022-29109-7 |
| spellingShingle | Xueguang Zhang Lingbo Wang Yongyi Ma Yan Wang Hongqian Liu Mohan Liu Lang Qin Jinghong Li Chuan Jiang Xiaojian Zhang Xudong Shan Yuliang Liu Jinsong Li Yaqian Li Rui Zheng Yongkang Sun Jianfeng Sun Xiangyou Leng Yan Liang Feng Zhang Xiaohui Jiang Yihong Yang Ying Shen CEP128 is involved in spermatogenesis in humans and mice Nature Communications |
| title | CEP128 is involved in spermatogenesis in humans and mice |
| title_full | CEP128 is involved in spermatogenesis in humans and mice |
| title_fullStr | CEP128 is involved in spermatogenesis in humans and mice |
| title_full_unstemmed | CEP128 is involved in spermatogenesis in humans and mice |
| title_short | CEP128 is involved in spermatogenesis in humans and mice |
| title_sort | cep128 is involved in spermatogenesis in humans and mice |
| url | https://doi.org/10.1038/s41467-022-29109-7 |
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