The majority of β-catenin mutations in colorectal cancer is homozygous

The majority of β-catenin mutations in colorectal cancer is homozygous

Abstract Background β-catenin activation plays a crucial role for tumourigenesis in the large intestine but except for Lynch syndrome (LS) associated cancers stabilizing mutations of β-catenin gene (CTNNB1) are rare in colorectal cancer (CRC). Previous animal studies provide an explanation for this...

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Bibliographic Details
Main Authors: Alexander Arnold, Moritz Tronser, Christine Sers, Ayel Ahadova, Volker Endris, Soulafa Mamlouk, David Horst, Markus Möbs, Philip Bischoff, Michael Kloor, Hendrik Bläker
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Cancer
Subjects:
Colorectal cancer (CRC)
ß-catenin (CTNNB1)
E-cadherin
Online Access:http://link.springer.com/article/10.1186/s12885-020-07537-2

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