A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer: Potential Treatment Target
Esophageal cancer is one of the most lethal malignancies worldwide. For locally advanced diseases, radiotherapy is the main treatment. The survival rates, however, are still appalling, which is partially due to radioresistance. In 6% of cases of esophageal cancer, the Hedgehog pathway is reactivated...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-04-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338231169873 |
| _version_ | 1797845321713188864 |
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| author | Li Ma MD Yu Wang MD Peng Chen MD Shixiu Wu MD |
| author_facet | Li Ma MD Yu Wang MD Peng Chen MD Shixiu Wu MD |
| author_sort | Li Ma MD |
| collection | DOAJ |
| description | Esophageal cancer is one of the most lethal malignancies worldwide. For locally advanced diseases, radiotherapy is the main treatment. The survival rates, however, are still appalling, which is partially due to radioresistance. In 6% of cases of esophageal cancer, the Hedgehog pathway is reactivated, and this pathway is crucial for the growth, progression, treatment resistance, and metastasis of esophageal cancer. Here, we conducted a comprehensive review of the current research on Hedgehog pathway in esophageal cancer. |
| first_indexed | 2024-04-09T17:38:19Z |
| format | Article |
| id | doaj.art-4079701752c94bd6a4f7db00e6284a61 |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-04-09T17:38:19Z |
| publishDate | 2023-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-4079701752c94bd6a4f7db00e6284a612023-04-17T10:33:31ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382023-04-012210.1177/15330338231169873A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer: Potential Treatment TargetLi Ma MD0Yu Wang MD1Peng Chen MD2Shixiu Wu MD3 National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China Department of Urology, South China Hospital, Medical School, Shenzhen University, Shenzhen, P.R. China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China Department of Oncology, , Wenzhou, Zhejiang, ChinaEsophageal cancer is one of the most lethal malignancies worldwide. For locally advanced diseases, radiotherapy is the main treatment. The survival rates, however, are still appalling, which is partially due to radioresistance. In 6% of cases of esophageal cancer, the Hedgehog pathway is reactivated, and this pathway is crucial for the growth, progression, treatment resistance, and metastasis of esophageal cancer. Here, we conducted a comprehensive review of the current research on Hedgehog pathway in esophageal cancer.https://doi.org/10.1177/15330338231169873 |
| spellingShingle | Li Ma MD Yu Wang MD Peng Chen MD Shixiu Wu MD A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer: Potential Treatment Target Technology in Cancer Research & Treatment |
| title | A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer:
Potential Treatment Target |
| title_full | A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer:
Potential Treatment Target |
| title_fullStr | A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer:
Potential Treatment Target |
| title_full_unstemmed | A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer:
Potential Treatment Target |
| title_short | A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer:
Potential Treatment Target |
| title_sort | review of hedgehog signaling in radioresistant esophageal cancer potential treatment target |
| url | https://doi.org/10.1177/15330338231169873 |
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