Trigeminal Nerve Control of Cerebral Blood Flow: A Brief Review
The trigeminal nerve, the fifth cranial nerve, is known to innervate much of the cerebral arterial vasculature and significantly contributes to the control of cerebrovascular tone in both healthy and diseased states. Previous studies have demonstrated that stimulation of the trigeminal nerve (TNS) i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.649910/full |
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| author | Timothy G. White Timothy G. White Keren Powell Kevin A. Shah Henry H. Woo Raj K. Narayan Raj K. Narayan Chunyan Li Chunyan Li |
| author_facet | Timothy G. White Timothy G. White Keren Powell Kevin A. Shah Henry H. Woo Raj K. Narayan Raj K. Narayan Chunyan Li Chunyan Li |
| author_sort | Timothy G. White |
| collection | DOAJ |
| description | The trigeminal nerve, the fifth cranial nerve, is known to innervate much of the cerebral arterial vasculature and significantly contributes to the control of cerebrovascular tone in both healthy and diseased states. Previous studies have demonstrated that stimulation of the trigeminal nerve (TNS) increases cerebral blood flow (CBF) via antidromic, trigemino-parasympathetic, and other central pathways. Despite some previous reports on the role of the trigeminal nerve and its control of CBF, there are only a few studies that investigate the effects of TNS on disorders of cerebral perfusion (i.e., ischemic stroke, subarachnoid hemorrhage, and traumatic brain injury). In this mini review, we present the current knowledge regarding the mechanisms of trigeminal nerve control of CBF, the anatomic underpinnings for targeted treatment, and potential clinical applications of TNS, with a focus on the treatment of impaired cerebral perfusion. |
| first_indexed | 2024-12-14T13:02:09Z |
| format | Article |
| id | doaj.art-407a8d07d4684cb29bc60efc252d6c17 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-14T13:02:09Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-407a8d07d4684cb29bc60efc252d6c172022-12-21T23:00:24ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-04-011510.3389/fnins.2021.649910649910Trigeminal Nerve Control of Cerebral Blood Flow: A Brief ReviewTimothy G. White0Timothy G. White1Keren Powell2Kevin A. Shah3Henry H. Woo4Raj K. Narayan5Raj K. Narayan6Chunyan Li7Chunyan Li8Translational Brain Research Laboratory, The Feinstein Institutes for Medical Research, Manhasset, NY, United StatesDepartment of Neurosurgery, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United StatesTranslational Brain Research Laboratory, The Feinstein Institutes for Medical Research, Manhasset, NY, United StatesDepartment of Neurosurgery, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United StatesDepartment of Neurosurgery, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United StatesTranslational Brain Research Laboratory, The Feinstein Institutes for Medical Research, Manhasset, NY, United StatesDepartment of Neurosurgery, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United StatesTranslational Brain Research Laboratory, The Feinstein Institutes for Medical Research, Manhasset, NY, United StatesDepartment of Neurosurgery, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United StatesThe trigeminal nerve, the fifth cranial nerve, is known to innervate much of the cerebral arterial vasculature and significantly contributes to the control of cerebrovascular tone in both healthy and diseased states. Previous studies have demonstrated that stimulation of the trigeminal nerve (TNS) increases cerebral blood flow (CBF) via antidromic, trigemino-parasympathetic, and other central pathways. Despite some previous reports on the role of the trigeminal nerve and its control of CBF, there are only a few studies that investigate the effects of TNS on disorders of cerebral perfusion (i.e., ischemic stroke, subarachnoid hemorrhage, and traumatic brain injury). In this mini review, we present the current knowledge regarding the mechanisms of trigeminal nerve control of CBF, the anatomic underpinnings for targeted treatment, and potential clinical applications of TNS, with a focus on the treatment of impaired cerebral perfusion.https://www.frontiersin.org/articles/10.3389/fnins.2021.649910/fulltrigeminal nervetrigeminal nerve stimulationcerebral blood flowcerebral perfusioncerebrovascular resistanceneurogenic control of cerebral vasodilation |
| spellingShingle | Timothy G. White Timothy G. White Keren Powell Kevin A. Shah Henry H. Woo Raj K. Narayan Raj K. Narayan Chunyan Li Chunyan Li Trigeminal Nerve Control of Cerebral Blood Flow: A Brief Review Frontiers in Neuroscience trigeminal nerve trigeminal nerve stimulation cerebral blood flow cerebral perfusion cerebrovascular resistance neurogenic control of cerebral vasodilation |
| title | Trigeminal Nerve Control of Cerebral Blood Flow: A Brief Review |
| title_full | Trigeminal Nerve Control of Cerebral Blood Flow: A Brief Review |
| title_fullStr | Trigeminal Nerve Control of Cerebral Blood Flow: A Brief Review |
| title_full_unstemmed | Trigeminal Nerve Control of Cerebral Blood Flow: A Brief Review |
| title_short | Trigeminal Nerve Control of Cerebral Blood Flow: A Brief Review |
| title_sort | trigeminal nerve control of cerebral blood flow a brief review |
| topic | trigeminal nerve trigeminal nerve stimulation cerebral blood flow cerebral perfusion cerebrovascular resistance neurogenic control of cerebral vasodilation |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.649910/full |
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