Regulation of Metabolic Activity by p53
Metabolic reprogramming in cancer cells is controlled by the activation of multiple oncogenic signalling pathways in order to promote macromolecule biosynthesis during rapid proliferation. Cancer cells also need to adapt their metabolism to survive and multiply under the metabolically compromised co...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-05-01
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| Series: | Metabolites |
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| Online Access: | http://www.mdpi.com/2218-1989/7/2/21 |
| _version_ | 1811344420677615616 |
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| author | Jessica Flöter Irem Kaymak Almut Schulze |
| author_facet | Jessica Flöter Irem Kaymak Almut Schulze |
| author_sort | Jessica Flöter |
| collection | DOAJ |
| description | Metabolic reprogramming in cancer cells is controlled by the activation of multiple oncogenic signalling pathways in order to promote macromolecule biosynthesis during rapid proliferation. Cancer cells also need to adapt their metabolism to survive and multiply under the metabolically compromised conditions provided by the tumour microenvironment. The tumour suppressor p53 interacts with the metabolic network at multiple nodes, mostly to reduce anabolic metabolism and promote preservation of cellular energy under conditions of nutrient restriction. Inactivation of this tumour suppressor by deletion or mutation is a frequent event in human cancer. While loss of p53 function lifts an important barrier to cancer development by deleting cell cycle and apoptosis checkpoints, it also removes a crucial regulatory mechanism and can render cancer cells highly sensitive to metabolic perturbation. In this review, we will summarise the major concepts of metabolic regulation by p53 and explore how this knowledge can be used to selectively target p53 deficient cancer cells in the context of the tumour microenvironment. |
| first_indexed | 2024-04-13T19:47:03Z |
| format | Article |
| id | doaj.art-407c9b3026f24aaaa7313ec38a37baf0 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-04-13T19:47:03Z |
| publishDate | 2017-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-407c9b3026f24aaaa7313ec38a37baf02022-12-22T02:32:41ZengMDPI AGMetabolites2218-19892017-05-01722110.3390/metabo7020021metabo7020021Regulation of Metabolic Activity by p53Jessica Flöter0Irem Kaymak1Almut Schulze2Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Am Hubland, 97074 Würzburg, GermanyDepartment of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Am Hubland, 97074 Würzburg, GermanyDepartment of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Am Hubland, 97074 Würzburg, GermanyMetabolic reprogramming in cancer cells is controlled by the activation of multiple oncogenic signalling pathways in order to promote macromolecule biosynthesis during rapid proliferation. Cancer cells also need to adapt their metabolism to survive and multiply under the metabolically compromised conditions provided by the tumour microenvironment. The tumour suppressor p53 interacts with the metabolic network at multiple nodes, mostly to reduce anabolic metabolism and promote preservation of cellular energy under conditions of nutrient restriction. Inactivation of this tumour suppressor by deletion or mutation is a frequent event in human cancer. While loss of p53 function lifts an important barrier to cancer development by deleting cell cycle and apoptosis checkpoints, it also removes a crucial regulatory mechanism and can render cancer cells highly sensitive to metabolic perturbation. In this review, we will summarise the major concepts of metabolic regulation by p53 and explore how this knowledge can be used to selectively target p53 deficient cancer cells in the context of the tumour microenvironment.http://www.mdpi.com/2218-1989/7/2/21cancer metabolismp53 tumour suppressorfatty acid metabolismcholesterolmicroenvironment |
| spellingShingle | Jessica Flöter Irem Kaymak Almut Schulze Regulation of Metabolic Activity by p53 Metabolites cancer metabolism p53 tumour suppressor fatty acid metabolism cholesterol microenvironment |
| title | Regulation of Metabolic Activity by p53 |
| title_full | Regulation of Metabolic Activity by p53 |
| title_fullStr | Regulation of Metabolic Activity by p53 |
| title_full_unstemmed | Regulation of Metabolic Activity by p53 |
| title_short | Regulation of Metabolic Activity by p53 |
| title_sort | regulation of metabolic activity by p53 |
| topic | cancer metabolism p53 tumour suppressor fatty acid metabolism cholesterol microenvironment |
| url | http://www.mdpi.com/2218-1989/7/2/21 |
| work_keys_str_mv | AT jessicafloter regulationofmetabolicactivitybyp53 AT iremkaymak regulationofmetabolicactivitybyp53 AT almutschulze regulationofmetabolicactivitybyp53 |