Liganded T3 receptor β2 inhibits the positive feedback autoregulation of the gene for GATA2, a transcription factor critical for thyrotropin production.

Liganded T3 receptor β2 inhibits the positive feedback autoregulation of the gene for GATA2, a transcription factor critical for thyrotropin production.

The serum concentration of thyrotropin (thyroid stimulating hormone, TSH) is drastically reduced by small increase in the levels of thyroid hormones (T3 and its prohormone, T4); however, the mechanism underlying this relationship is unknown. TSH consists of the chorionic gonadotropin α (CGA) and the...

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Main Authors: Naoko Hirahara, Hiroko Misawa Nakamura, Shigekazu Sasaki, Akio Matsushita, Kenji Ohba, Go Kuroda, Yuki Sakai, Shinsuke Shinkai, Hiroshi Haeno, Takuhiro Nishio, Shuichi Yoshida, Yutaka Oki, Takafumi Suda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0227646

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