Electrical impulses evoked activity patterns in ventral tegmental area and locus coeruleus modulate endogenous and learning-dependent disparity of cell proliferation along the mouse dentate gyrus
This study aimed to examine the effects of the ventral tegmental area (VTA) and the locus coeruleus (LC) patterned electrical stimulation on hippocampal-dependent learning and hippocampal neurogenesis in adult mouse. For this, mice were given unilateral electrical stimulation of VTA or LC using phas...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | IBRO Neuroscience Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242123000192 |
| _version_ | 1797804522179919872 |
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| author | Zohreh Tavassoli Mohammad Javan Narges Hosseinmardi Yaghoub Fathollahi |
| author_facet | Zohreh Tavassoli Mohammad Javan Narges Hosseinmardi Yaghoub Fathollahi |
| author_sort | Zohreh Tavassoli |
| collection | DOAJ |
| description | This study aimed to examine the effects of the ventral tegmental area (VTA) and the locus coeruleus (LC) patterned electrical stimulation on hippocampal-dependent learning and hippocampal neurogenesis in adult mouse. For this, mice were given unilateral electrical stimulation of VTA or LC using phasic or tonic stimulation protocols. Behavior acquisition rates were evaluated using the Barnes maze (BM) and a passive avoidance (PA) task. Cell proliferation was measured in the dorsal (dDG), intermediate (iDG) and ventral (vDG) dentate gyrus (DG) using Ki67 immunohistochemistry. We showed that the levels of cell proliferation were significantly different in three highlighted parts of the DG. The behavioral testing paradigms themselves were sufficient to alter cell proliferation indices along the dentate gyrus. The phasic LC modulation treatment enhanced behavioral acquisition of the BM and cell proliferation in the dDG, while tonic VTA stimulation improved PA acquisition and increased cell proliferation in the iDG. It is concluded that electrical impulses-evoked phasic or tonic activity patterns in the LC and VTA could modulate endogenous and learning dependent disparity of cell proliferation along the adult mouse DG. |
| first_indexed | 2024-03-13T05:38:26Z |
| format | Article |
| id | doaj.art-408671b00fc043f8b36121ccd6c8a494 |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-03-13T05:38:26Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-408671b00fc043f8b36121ccd6c8a4942023-06-14T04:34:40ZengElsevierIBRO Neuroscience Reports2667-24212023-06-0114293307Electrical impulses evoked activity patterns in ventral tegmental area and locus coeruleus modulate endogenous and learning-dependent disparity of cell proliferation along the mouse dentate gyrusZohreh Tavassoli0Mohammad Javan1Narges Hosseinmardi2Yaghoub Fathollahi3Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranDepartment of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Corresponding author.This study aimed to examine the effects of the ventral tegmental area (VTA) and the locus coeruleus (LC) patterned electrical stimulation on hippocampal-dependent learning and hippocampal neurogenesis in adult mouse. For this, mice were given unilateral electrical stimulation of VTA or LC using phasic or tonic stimulation protocols. Behavior acquisition rates were evaluated using the Barnes maze (BM) and a passive avoidance (PA) task. Cell proliferation was measured in the dorsal (dDG), intermediate (iDG) and ventral (vDG) dentate gyrus (DG) using Ki67 immunohistochemistry. We showed that the levels of cell proliferation were significantly different in three highlighted parts of the DG. The behavioral testing paradigms themselves were sufficient to alter cell proliferation indices along the dentate gyrus. The phasic LC modulation treatment enhanced behavioral acquisition of the BM and cell proliferation in the dDG, while tonic VTA stimulation improved PA acquisition and increased cell proliferation in the iDG. It is concluded that electrical impulses-evoked phasic or tonic activity patterns in the LC and VTA could modulate endogenous and learning dependent disparity of cell proliferation along the adult mouse DG.http://www.sciencedirect.com/science/article/pii/S2667242123000192VTALCActivity patternsCell proliferation disparityHippocampusMemory |
| spellingShingle | Zohreh Tavassoli Mohammad Javan Narges Hosseinmardi Yaghoub Fathollahi Electrical impulses evoked activity patterns in ventral tegmental area and locus coeruleus modulate endogenous and learning-dependent disparity of cell proliferation along the mouse dentate gyrus IBRO Neuroscience Reports VTA LC Activity patterns Cell proliferation disparity Hippocampus Memory |
| title | Electrical impulses evoked activity patterns in ventral tegmental area and locus coeruleus modulate endogenous and learning-dependent disparity of cell proliferation along the mouse dentate gyrus |
| title_full | Electrical impulses evoked activity patterns in ventral tegmental area and locus coeruleus modulate endogenous and learning-dependent disparity of cell proliferation along the mouse dentate gyrus |
| title_fullStr | Electrical impulses evoked activity patterns in ventral tegmental area and locus coeruleus modulate endogenous and learning-dependent disparity of cell proliferation along the mouse dentate gyrus |
| title_full_unstemmed | Electrical impulses evoked activity patterns in ventral tegmental area and locus coeruleus modulate endogenous and learning-dependent disparity of cell proliferation along the mouse dentate gyrus |
| title_short | Electrical impulses evoked activity patterns in ventral tegmental area and locus coeruleus modulate endogenous and learning-dependent disparity of cell proliferation along the mouse dentate gyrus |
| title_sort | electrical impulses evoked activity patterns in ventral tegmental area and locus coeruleus modulate endogenous and learning dependent disparity of cell proliferation along the mouse dentate gyrus |
| topic | VTA LC Activity patterns Cell proliferation disparity Hippocampus Memory |
| url | http://www.sciencedirect.com/science/article/pii/S2667242123000192 |
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