Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability

Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability

Topoisomerase 1 (Top1) removes transcription-associated helical stress to sup-press G4-formation and its induced recombination at genomic loci containing guanine-run containing sequences. Interestingly, Top1 binds tightly to G4 struc-tures, and its inhibition or depletion can cause elevated instabil...

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Bibliographic Details
Main Authors: Alexandra Berroyer, Albino Bacolla, John A. Tainer, Nayun Kim
Format: Article
Language:English
Published: Shared Science Publishers OG 2022-01-01
Series:Microbial Cell
Subjects:
g-quadruplex
topoisomerase
transcription
recombination
genome instability
Online Access:http://microbialcell.com/researcharticles/2022a-berroyer-microbial-cell/

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http://microbialcell.com/researcharticles/2022a-berroyer-microbial-cell/

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