Characterizing fitness and immune escape of SARS-CoV-2 EG.5 sublineage using elderly serum and nasal organoid

Characterizing fitness and immune escape of SARS-CoV-2 EG.5 sublineage using elderly serum and nasal organoid

Summary: SARS-CoV-2 Omicron variant has evolved into sublineages. Here, we compared the neutralization susceptibility and viral fitness of EG.5.1 and XBB.1.9.1. Serum neutralization antibody titer against EG.5.1 was 1.71-fold lower than that for XBB.1.9.1. However, there was no significant differenc...

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Bibliographic Details
Main Authors: Xiaojuan Zhang, Stephanie Joy-Ann Lam, Jonathan Daniel Ip, Carol Ho-Yan Fong, Allen Wing-Ho Chu, Wan-Mui Chan, Yoyo Suet-Yiu Lai, Hoi-Wah Tsoi, Brian Pui-Chun Chan, Lin-Lei Chen, Xinjie Meng, Shuofeng Yuan, Hanjun Zhao, Vincent Chi-Chung Cheng, Jacqueline Kwan Yuk Yuen, Kwok-Yung Yuen, Jie Zhou, Kelvin Kai-Wang To
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:iScience
Subjects:
Immunology
Immune response
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224009283

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