Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth
The success of pulpotomy of young permanent teeth depends on the proper selection of dressing materials. This study aimed to evaluate the histological and histomorphometric response of dentin–pulp complex to the enamel matrix derivative (Emdogain ® gel) compared to that of calcium hydroxide when use...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2014-01-01
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| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/2041731414521707 |
| _version_ | 1818442454435627008 |
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| author | Sherif S Darwish Shadia H Abd El Meguid Nadia A Wahba Ahmed A-R Mohamed Wojciech Chrzanowski Ensanya A Abou Neel |
| author_facet | Sherif S Darwish Shadia H Abd El Meguid Nadia A Wahba Ahmed A-R Mohamed Wojciech Chrzanowski Ensanya A Abou Neel |
| author_sort | Sherif S Darwish |
| collection | DOAJ |
| description | The success of pulpotomy of young permanent teeth depends on the proper selection of dressing materials. This study aimed to evaluate the histological and histomorphometric response of dentin–pulp complex to the enamel matrix derivative (Emdogain ® gel) compared to that of calcium hydroxide when used as a pulp dressing in immature young permanent dogs’ teeth. Dentin-like tissues bridging the full width of the coronal pulp at the interface between the injured and healthy pulp tissues were seen after 1 month in both groups. With time, the dentin bridge increased in thickness for calcium hydroxide but disintegrated and fully disappeared for Emdogain-treated group. Progressive inflammation and total pulp degeneration were only evident with Emdogain-treated group. The root apices of Emdogain-treated teeth became matured and closed by cementum that attached to new alveolar bone by a well-oriented periodontal ligament. In young permanent dentition, Emdogain could be a good candidate for periodontium but not dentino–pulpal complex regeneration. |
| first_indexed | 2024-12-14T18:44:24Z |
| format | Article |
| id | doaj.art-408a7475da7048ff9786f15346c28f46 |
| institution | Directory Open Access Journal |
| issn | 2041-7314 |
| language | English |
| last_indexed | 2024-12-14T18:44:24Z |
| publishDate | 2014-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj.art-408a7475da7048ff9786f15346c28f462022-12-21T22:51:25ZengSAGE PublishingJournal of Tissue Engineering2041-73142014-01-01510.1177/204173141452170710.1177_2041731414521707Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teethSherif S Darwish0Shadia H Abd El Meguid1Nadia A Wahba2Ahmed A-R Mohamed3Wojciech Chrzanowski4Ensanya A Abou Neel5Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Pharos University, EgyptOral Biology Department, Faculty of Dentistry, Alexandria University, EgyptPediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, EgyptPediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, EgyptThe Faculty of Pharmacy, The University of Sydney, NSW 2006 AustraliaUCL Eastman Dental Institute, Biomaterials and Tissue Engineering Division, 256 Gray’s Inn Road, London, WC1X 8LDThe success of pulpotomy of young permanent teeth depends on the proper selection of dressing materials. This study aimed to evaluate the histological and histomorphometric response of dentin–pulp complex to the enamel matrix derivative (Emdogain ® gel) compared to that of calcium hydroxide when used as a pulp dressing in immature young permanent dogs’ teeth. Dentin-like tissues bridging the full width of the coronal pulp at the interface between the injured and healthy pulp tissues were seen after 1 month in both groups. With time, the dentin bridge increased in thickness for calcium hydroxide but disintegrated and fully disappeared for Emdogain-treated group. Progressive inflammation and total pulp degeneration were only evident with Emdogain-treated group. The root apices of Emdogain-treated teeth became matured and closed by cementum that attached to new alveolar bone by a well-oriented periodontal ligament. In young permanent dentition, Emdogain could be a good candidate for periodontium but not dentino–pulpal complex regeneration.https://doi.org/10.1177/2041731414521707 |
| spellingShingle | Sherif S Darwish Shadia H Abd El Meguid Nadia A Wahba Ahmed A-R Mohamed Wojciech Chrzanowski Ensanya A Abou Neel Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth Journal of Tissue Engineering |
| title | Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth |
| title_full | Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth |
| title_fullStr | Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth |
| title_full_unstemmed | Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth |
| title_short | Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth |
| title_sort | root maturation and dentin pulp response to enamel matrix derivative in pulpotomized permanent teeth |
| url | https://doi.org/10.1177/2041731414521707 |
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