Immune Checkpoint Therapy: Tumor Draining Lymph Nodes in the Spotlights
Tumor-draining lymph nodes play a paradoxical role in cancer. Surgeons often resect these sentinel lymph nodes to determine metastatic spread, thereby enabling prognosis and treatment. However, lymph nodes are vital organs for the orchestration of immune responses, due to the close encounters of ded...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/17/9401 |
| _version_ | 1797521296202924032 |
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| author | Marieke F. Fransen Thorbald van Hall Ferry Ossendorp |
| author_facet | Marieke F. Fransen Thorbald van Hall Ferry Ossendorp |
| author_sort | Marieke F. Fransen |
| collection | DOAJ |
| description | Tumor-draining lymph nodes play a paradoxical role in cancer. Surgeons often resect these sentinel lymph nodes to determine metastatic spread, thereby enabling prognosis and treatment. However, lymph nodes are vital organs for the orchestration of immune responses, due to the close encounters of dedicated immune cells. In view of the success of immunotherapy, the removal of tumor-draining lymph nodes needs to be re-evaluated and viewed in a different light. Recently, an important role for tumor-draining lymph nodes has been proposed in the immunotherapy of cancer. This new insight can change the use of immune checkpoint therapy, particularly with respect to the use in neoadjuvant settings in which lymph nodes are still operational. |
| first_indexed | 2024-03-10T08:10:35Z |
| format | Article |
| id | doaj.art-408aaaf642b148ab8165efe92fd3a9df |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:10:35Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-408aaaf642b148ab8165efe92fd3a9df2023-11-22T10:42:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012217940110.3390/ijms22179401Immune Checkpoint Therapy: Tumor Draining Lymph Nodes in the SpotlightsMarieke F. Fransen0Thorbald van Hall1Ferry Ossendorp2Department of Immunology, Leiden University Medical Center (LUMC), 2300 RC Leiden, The NetherlandsDepartment of Medical Oncology, Leiden University Medical Center (LUMC), 2300 RC Leiden, The NetherlandsDepartment of Immunology, Leiden University Medical Center (LUMC), 2300 RC Leiden, The NetherlandsTumor-draining lymph nodes play a paradoxical role in cancer. Surgeons often resect these sentinel lymph nodes to determine metastatic spread, thereby enabling prognosis and treatment. However, lymph nodes are vital organs for the orchestration of immune responses, due to the close encounters of dedicated immune cells. In view of the success of immunotherapy, the removal of tumor-draining lymph nodes needs to be re-evaluated and viewed in a different light. Recently, an important role for tumor-draining lymph nodes has been proposed in the immunotherapy of cancer. This new insight can change the use of immune checkpoint therapy, particularly with respect to the use in neoadjuvant settings in which lymph nodes are still operational.https://www.mdpi.com/1422-0067/22/17/9401cancerimmunotherapytumor-draining lymph nodescheckpoint blockersneoadjuvant |
| spellingShingle | Marieke F. Fransen Thorbald van Hall Ferry Ossendorp Immune Checkpoint Therapy: Tumor Draining Lymph Nodes in the Spotlights International Journal of Molecular Sciences cancer immunotherapy tumor-draining lymph nodes checkpoint blockers neoadjuvant |
| title | Immune Checkpoint Therapy: Tumor Draining Lymph Nodes in the Spotlights |
| title_full | Immune Checkpoint Therapy: Tumor Draining Lymph Nodes in the Spotlights |
| title_fullStr | Immune Checkpoint Therapy: Tumor Draining Lymph Nodes in the Spotlights |
| title_full_unstemmed | Immune Checkpoint Therapy: Tumor Draining Lymph Nodes in the Spotlights |
| title_short | Immune Checkpoint Therapy: Tumor Draining Lymph Nodes in the Spotlights |
| title_sort | immune checkpoint therapy tumor draining lymph nodes in the spotlights |
| topic | cancer immunotherapy tumor-draining lymph nodes checkpoint blockers neoadjuvant |
| url | https://www.mdpi.com/1422-0067/22/17/9401 |
| work_keys_str_mv | AT mariekeffransen immunecheckpointtherapytumordraininglymphnodesinthespotlights AT thorbaldvanhall immunecheckpointtherapytumordraininglymphnodesinthespotlights AT ferryossendorp immunecheckpointtherapytumordraininglymphnodesinthespotlights |