Acute and 28-days subacute toxicity studies of Gαq-RGS2 signaling inhibitor
Abstract Background The aim of study was to evaluate the single oral dose and 28 day repeated oral administration toxicity profile of the synthetic compound Gαq-RGS2 signaling inhibitor, (1-(5-chloro-2-hydroxyphenyl)-3-(4-(trifluoromethyl)phenyl)-1 H-1,2,4-triazol-5(4 H)-one) as per OECD guideline 4...
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | Laboratory Animal Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42826-021-00093-1 |
| _version_ | 1819073497607962624 |
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| author | Jayesh V. Beladiya Anita A. Mehta |
| author_facet | Jayesh V. Beladiya Anita A. Mehta |
| author_sort | Jayesh V. Beladiya |
| collection | DOAJ |
| description | Abstract Background The aim of study was to evaluate the single oral dose and 28 day repeated oral administration toxicity profile of the synthetic compound Gαq-RGS2 signaling inhibitor, (1-(5-chloro-2-hydroxyphenyl)-3-(4-(trifluoromethyl)phenyl)-1 H-1,2,4-triazol-5(4 H)-one) as per OECD guideline 425 (2008a) and 407 (2008b), respectively. Results In acute toxicity study, a single oral dose administration of Gαq-RGS2 signaling inhibitor did not show any mortality at doses of 5, 50, 300 and 2000 mg/kg within 24 h and 14 days. The treatment of Gαq-RGS2 signaling inhibitor at dose 10 and 100 mg/kg for 28 days did not show any mortality, significant changes in the increase of body weight, various organ damage markers, hematological parameters, relative organ/body weight ratio and microscopic anatomical texture of essential organs as compared to vehicle and normal control. Conclusions A single oral administration of Gαq-RGS2 signaling inhibitor up to dose of 2000 mg/kg in mice and repeated administration of Gαq-RGS2 signaling inhibitor at higher dose 100 mg/kg for 28 days in the rats is safe. |
| first_indexed | 2024-12-21T17:54:34Z |
| format | Article |
| id | doaj.art-408d5f94658e4b288699e857930e9801 |
| institution | Directory Open Access Journal |
| issn | 2233-7660 |
| language | English |
| last_indexed | 2024-12-21T17:54:34Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Laboratory Animal Research |
| spelling | doaj.art-408d5f94658e4b288699e857930e98012022-12-21T18:55:15ZengBMCLaboratory Animal Research2233-76602021-07-0137111010.1186/s42826-021-00093-1Acute and 28-days subacute toxicity studies of Gαq-RGS2 signaling inhibitorJayesh V. Beladiya0Anita A. Mehta1Department of Pharmacology, L. M. College of PharmacyDepartment of Pharmacology, L. M. College of PharmacyAbstract Background The aim of study was to evaluate the single oral dose and 28 day repeated oral administration toxicity profile of the synthetic compound Gαq-RGS2 signaling inhibitor, (1-(5-chloro-2-hydroxyphenyl)-3-(4-(trifluoromethyl)phenyl)-1 H-1,2,4-triazol-5(4 H)-one) as per OECD guideline 425 (2008a) and 407 (2008b), respectively. Results In acute toxicity study, a single oral dose administration of Gαq-RGS2 signaling inhibitor did not show any mortality at doses of 5, 50, 300 and 2000 mg/kg within 24 h and 14 days. The treatment of Gαq-RGS2 signaling inhibitor at dose 10 and 100 mg/kg for 28 days did not show any mortality, significant changes in the increase of body weight, various organ damage markers, hematological parameters, relative organ/body weight ratio and microscopic anatomical texture of essential organs as compared to vehicle and normal control. Conclusions A single oral administration of Gαq-RGS2 signaling inhibitor up to dose of 2000 mg/kg in mice and repeated administration of Gαq-RGS2 signaling inhibitor at higher dose 100 mg/kg for 28 days in the rats is safe.https://doi.org/10.1186/s42826-021-00093-1Acute toxicitySub-acute toxicityGαq-RGS2 signaling inhibitor28-days repeated dose toxicitySingle oral dose toxicity |
| spellingShingle | Jayesh V. Beladiya Anita A. Mehta Acute and 28-days subacute toxicity studies of Gαq-RGS2 signaling inhibitor Laboratory Animal Research Acute toxicity Sub-acute toxicity Gαq-RGS2 signaling inhibitor 28-days repeated dose toxicity Single oral dose toxicity |
| title | Acute and 28-days subacute toxicity studies of Gαq-RGS2 signaling inhibitor |
| title_full | Acute and 28-days subacute toxicity studies of Gαq-RGS2 signaling inhibitor |
| title_fullStr | Acute and 28-days subacute toxicity studies of Gαq-RGS2 signaling inhibitor |
| title_full_unstemmed | Acute and 28-days subacute toxicity studies of Gαq-RGS2 signaling inhibitor |
| title_short | Acute and 28-days subacute toxicity studies of Gαq-RGS2 signaling inhibitor |
| title_sort | acute and 28 days subacute toxicity studies of gαq rgs2 signaling inhibitor |
| topic | Acute toxicity Sub-acute toxicity Gαq-RGS2 signaling inhibitor 28-days repeated dose toxicity Single oral dose toxicity |
| url | https://doi.org/10.1186/s42826-021-00093-1 |
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