Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
Cells of the pulmonary vasculature show a hyperproliferative phenotype in pulmonary arterial hypertension (PAH), thus contributing to the disease pathogenesis. Here the authors show that cyclin-dependent kinases are overactivated in PAH, and that their pharmacological inhibition attenuates the disea...
Full description
Bibliographic Details
| Main Authors: |
Astrid Weiss,
Moritz Christian Neubauer,
Dinesh Yerabolu,
Baktybek Kojonazarov,
Beate Christiane Schlueter,
Lavinia Neubert,
Danny Jonigk,
Nelli Baal,
Clemens Ruppert,
Peter Dorfmuller,
Soni Savai Pullamsetti,
Norbert Weissmann,
Hossein-Ardeschir Ghofrani,
Friedrich Grimminger,
Werner Seeger,
Ralph Theo Schermuly |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Portfolio
2019-05-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-019-10135-x
|
|---|