Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension
Cells of the pulmonary vasculature show a hyperproliferative phenotype in pulmonary arterial hypertension (PAH), thus contributing to the disease pathogenesis. Here the authors show that cyclin-dependent kinases are overactivated in PAH, and that their pharmacological inhibition attenuates the disea...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10135-x |
| _version_ | 1831774148632772608 |
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| author | Astrid Weiss Moritz Christian Neubauer Dinesh Yerabolu Baktybek Kojonazarov Beate Christiane Schlueter Lavinia Neubert Danny Jonigk Nelli Baal Clemens Ruppert Peter Dorfmuller Soni Savai Pullamsetti Norbert Weissmann Hossein-Ardeschir Ghofrani Friedrich Grimminger Werner Seeger Ralph Theo Schermuly |
| author_facet | Astrid Weiss Moritz Christian Neubauer Dinesh Yerabolu Baktybek Kojonazarov Beate Christiane Schlueter Lavinia Neubert Danny Jonigk Nelli Baal Clemens Ruppert Peter Dorfmuller Soni Savai Pullamsetti Norbert Weissmann Hossein-Ardeschir Ghofrani Friedrich Grimminger Werner Seeger Ralph Theo Schermuly |
| author_sort | Astrid Weiss |
| collection | DOAJ |
| description | Cells of the pulmonary vasculature show a hyperproliferative phenotype in pulmonary arterial hypertension (PAH), thus contributing to the disease pathogenesis. Here the authors show that cyclin-dependent kinases are overactivated in PAH, and that their pharmacological inhibition attenuates the disease in two independent rodent models |
| first_indexed | 2024-12-22T08:49:05Z |
| format | Article |
| id | doaj.art-4090a81f202846ada6a47e71478ee836 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T08:49:05Z |
| publishDate | 2019-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4090a81f202846ada6a47e71478ee8362022-12-21T18:32:00ZengNature PortfolioNature Communications2041-17232019-05-0110111710.1038/s41467-019-10135-xTargeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertensionAstrid Weiss0Moritz Christian Neubauer1Dinesh Yerabolu2Baktybek Kojonazarov3Beate Christiane Schlueter4Lavinia Neubert5Danny Jonigk6Nelli Baal7Clemens Ruppert8Peter Dorfmuller9Soni Savai Pullamsetti10Norbert Weissmann11Hossein-Ardeschir Ghofrani12Friedrich Grimminger13Werner Seeger14Ralph Theo Schermuly15Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Member of the German Center for Lung Research (DZL)Member of the German Center for Lung Research (DZL)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Member of the German Center for Lung Research (DZL)Universities of Giessen and Marburg Lung Center (UGMLC)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Justus-Liebig-University Giessen (JLU)Cells of the pulmonary vasculature show a hyperproliferative phenotype in pulmonary arterial hypertension (PAH), thus contributing to the disease pathogenesis. Here the authors show that cyclin-dependent kinases are overactivated in PAH, and that their pharmacological inhibition attenuates the disease in two independent rodent modelshttps://doi.org/10.1038/s41467-019-10135-x |
| spellingShingle | Astrid Weiss Moritz Christian Neubauer Dinesh Yerabolu Baktybek Kojonazarov Beate Christiane Schlueter Lavinia Neubert Danny Jonigk Nelli Baal Clemens Ruppert Peter Dorfmuller Soni Savai Pullamsetti Norbert Weissmann Hossein-Ardeschir Ghofrani Friedrich Grimminger Werner Seeger Ralph Theo Schermuly Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension Nature Communications |
| title | Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension |
| title_full | Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension |
| title_fullStr | Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension |
| title_full_unstemmed | Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension |
| title_short | Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension |
| title_sort | targeting cyclin dependent kinases for the treatment of pulmonary arterial hypertension |
| url | https://doi.org/10.1038/s41467-019-10135-x |
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