NR4A Family Genes: A Review of Comprehensive Prognostic and Gene Expression Profile Analysis in Breast Cancer
This report analyzes nuclear receptor (NR) subfamily 4A’s potential role in treating those diagnosed with breast cancer. Here we reviewed the current literature on NR4 family members. We also examined the relative gene expression of the NR4A receptor subfamily in the basal, HER2 (human epidermal gro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.777824/full |
| _version_ | 1818127659417206784 |
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| author | Hassan Yousefi Hassan Yousefi Jordyn Fong Suresh K. Alahari Suresh K. Alahari |
| author_facet | Hassan Yousefi Hassan Yousefi Jordyn Fong Suresh K. Alahari Suresh K. Alahari |
| author_sort | Hassan Yousefi |
| collection | DOAJ |
| description | This report analyzes nuclear receptor (NR) subfamily 4A’s potential role in treating those diagnosed with breast cancer. Here we reviewed the current literature on NR4 family members. We also examined the relative gene expression of the NR4A receptor subfamily in the basal, HER2 (human epidermal growth factor receptor 2) positive, luminal A, and luminal B subtypes using data from tumor samples in The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC). These data showed a positive link between NR4A1-NR4A3 expression and increased overall survival and relapse-free survival in breast cancer patients. In addition, we observed that high expression of NR4A1, NR4A2, and NR4A3 led to better survival. Furthermore, NR4A family genes seem to play an essential regulatory role in glycolysis and oxidative phosphorylation in breast cancer. The novel prognostic role of the NR4A1–NR4A3 receptors implicates these receptors as important mediators controlling breast cancer metabolic reprograming and its progression. The review establishes a strong clinical basis for the investigation of the cellular, molecular, and physiological roles of NR4A genes in breast cancer. |
| first_indexed | 2024-12-11T07:20:52Z |
| format | Article |
| id | doaj.art-40917b8787e24a5db57bd7644bc4c2fd |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-11T07:20:52Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-40917b8787e24a5db57bd7644bc4c2fd2022-12-22T01:16:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.777824777824NR4A Family Genes: A Review of Comprehensive Prognostic and Gene Expression Profile Analysis in Breast CancerHassan Yousefi0Hassan Yousefi1Jordyn Fong2Suresh K. Alahari3Suresh K. Alahari4Department of Biochemistry and Molecular Biology, Louisiana State University Health Science Center (LSUHSC), New Orleans, LA, United StatesStanley S. Scott Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, United StatesBiological Sciences, Louisiana State University, Baton Rouge, LA, United StatesDepartment of Biochemistry and Molecular Biology, Louisiana State University Health Science Center (LSUHSC), New Orleans, LA, United StatesStanley S. Scott Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, United StatesThis report analyzes nuclear receptor (NR) subfamily 4A’s potential role in treating those diagnosed with breast cancer. Here we reviewed the current literature on NR4 family members. We also examined the relative gene expression of the NR4A receptor subfamily in the basal, HER2 (human epidermal growth factor receptor 2) positive, luminal A, and luminal B subtypes using data from tumor samples in The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC). These data showed a positive link between NR4A1-NR4A3 expression and increased overall survival and relapse-free survival in breast cancer patients. In addition, we observed that high expression of NR4A1, NR4A2, and NR4A3 led to better survival. Furthermore, NR4A family genes seem to play an essential regulatory role in glycolysis and oxidative phosphorylation in breast cancer. The novel prognostic role of the NR4A1–NR4A3 receptors implicates these receptors as important mediators controlling breast cancer metabolic reprograming and its progression. The review establishes a strong clinical basis for the investigation of the cellular, molecular, and physiological roles of NR4A genes in breast cancer.https://www.frontiersin.org/articles/10.3389/fonc.2022.777824/fullNR4Abreast cancersurvivalTCGAMETABRIC |
| spellingShingle | Hassan Yousefi Hassan Yousefi Jordyn Fong Suresh K. Alahari Suresh K. Alahari NR4A Family Genes: A Review of Comprehensive Prognostic and Gene Expression Profile Analysis in Breast Cancer Frontiers in Oncology NR4A breast cancer survival TCGA METABRIC |
| title | NR4A Family Genes: A Review of Comprehensive Prognostic and Gene Expression Profile Analysis in Breast Cancer |
| title_full | NR4A Family Genes: A Review of Comprehensive Prognostic and Gene Expression Profile Analysis in Breast Cancer |
| title_fullStr | NR4A Family Genes: A Review of Comprehensive Prognostic and Gene Expression Profile Analysis in Breast Cancer |
| title_full_unstemmed | NR4A Family Genes: A Review of Comprehensive Prognostic and Gene Expression Profile Analysis in Breast Cancer |
| title_short | NR4A Family Genes: A Review of Comprehensive Prognostic and Gene Expression Profile Analysis in Breast Cancer |
| title_sort | nr4a family genes a review of comprehensive prognostic and gene expression profile analysis in breast cancer |
| topic | NR4A breast cancer survival TCGA METABRIC |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.777824/full |
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