Preparation and Characterization of Montelukast Sodium ( SMLT ) as a Dual Sustained Release Buccal Strips
An oral bi layer sustained release (SR) strips of Sodium Montelukast SMLT , which is selective leukotriene antagonist , used for patients suffered from mid-night asthma , were prepared successfully ,using different polymers, like guar gum , carrageenan , and xanthan gum , by solvent casting...
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| Format: | Article |
| Language: | English |
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College of Pharmacy University of Baghdad
2017-03-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/368 |
| _version_ | 1818402412795265024 |
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| author | Yehia I.Khalil |
| author_facet | Yehia I.Khalil |
| author_sort | Yehia I.Khalil |
| collection | DOAJ |
| description | An oral bi layer sustained release (SR) strips of Sodium Montelukast SMLT , which is selective leukotriene antagonist , used for patients suffered from mid-night asthma , were prepared successfully ,using different polymers, like guar gum , carrageenan , and xanthan gum , by solvent casting method .
The results obtained by this study revealed ,that best fast dissolving film of SMLT was loaded in carrageenan polymer 57% w\w (30mg.) , with acceptable physical properties, like film thickness , elastic endurance and surface pH .
Besides to that , the disintegration time , and cumulative 80% drug release were estimated 22 seconds and 3.7 minutes , respectively .On the other hand , the sustained release film ( FSR6-7 ) as a second layer , appear to be the most promised layer of SMLT loaded in 50 % w\w (15mg.) PVP K17 , with respect to its film thickness, elastic endurance and , surface pH .
Moreover the , the disintegration time of the second layer film was 21seconds , and the time for 50% drug release was 15 minutes extended for 4hours of 100% drug release .
Meanwhile , the investigation of possible interference between the drug , and, polymers used revealed no evidence of this effect ,using FTIR , and SEM technique . In an attempt to evaluate the extended release effect of the selected formula , Singulair® plain tablet as a marketed product was used , the result gave more than 4 hours of selected formula , compared with 30 minutes to marketed product Singulair® .
The overall results candidates the selected FSR6-7 formula as a promised bi layer buccal fast , as compliance and extended therapy for asthmatic mid- night patients.
Keywords: Montelukast sodium, Dual buccal strips, Guar gum, Xanthan gum, Carrageenan. |
| first_indexed | 2024-12-14T08:07:57Z |
| format | Article |
| id | doaj.art-4091934a63764c42ad70bc0bde81e200 |
| institution | Directory Open Access Journal |
| issn | 2521-3512 1683-3597 |
| language | English |
| last_indexed | 2024-12-14T08:07:57Z |
| publishDate | 2017-03-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj.art-4091934a63764c42ad70bc0bde81e2002022-12-21T23:10:08ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences2521-35121683-35972017-03-0124210.31351/vol24iss2pp61-71Preparation and Characterization of Montelukast Sodium ( SMLT ) as a Dual Sustained Release Buccal StripsYehia I.KhalilAn oral bi layer sustained release (SR) strips of Sodium Montelukast SMLT , which is selective leukotriene antagonist , used for patients suffered from mid-night asthma , were prepared successfully ,using different polymers, like guar gum , carrageenan , and xanthan gum , by solvent casting method . The results obtained by this study revealed ,that best fast dissolving film of SMLT was loaded in carrageenan polymer 57% w\w (30mg.) , with acceptable physical properties, like film thickness , elastic endurance and surface pH . Besides to that , the disintegration time , and cumulative 80% drug release were estimated 22 seconds and 3.7 minutes , respectively .On the other hand , the sustained release film ( FSR6-7 ) as a second layer , appear to be the most promised layer of SMLT loaded in 50 % w\w (15mg.) PVP K17 , with respect to its film thickness, elastic endurance and , surface pH . Moreover the , the disintegration time of the second layer film was 21seconds , and the time for 50% drug release was 15 minutes extended for 4hours of 100% drug release . Meanwhile , the investigation of possible interference between the drug , and, polymers used revealed no evidence of this effect ,using FTIR , and SEM technique . In an attempt to evaluate the extended release effect of the selected formula , Singulair® plain tablet as a marketed product was used , the result gave more than 4 hours of selected formula , compared with 30 minutes to marketed product Singulair® . The overall results candidates the selected FSR6-7 formula as a promised bi layer buccal fast , as compliance and extended therapy for asthmatic mid- night patients. Keywords: Montelukast sodium, Dual buccal strips, Guar gum, Xanthan gum, Carrageenan.https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/368 |
| spellingShingle | Yehia I.Khalil Preparation and Characterization of Montelukast Sodium ( SMLT ) as a Dual Sustained Release Buccal Strips Iraqi Journal of Pharmaceutical Sciences |
| title | Preparation and Characterization of Montelukast Sodium ( SMLT ) as a Dual Sustained Release Buccal Strips |
| title_full | Preparation and Characterization of Montelukast Sodium ( SMLT ) as a Dual Sustained Release Buccal Strips |
| title_fullStr | Preparation and Characterization of Montelukast Sodium ( SMLT ) as a Dual Sustained Release Buccal Strips |
| title_full_unstemmed | Preparation and Characterization of Montelukast Sodium ( SMLT ) as a Dual Sustained Release Buccal Strips |
| title_short | Preparation and Characterization of Montelukast Sodium ( SMLT ) as a Dual Sustained Release Buccal Strips |
| title_sort | preparation and characterization of montelukast sodium smlt as a dual sustained release buccal strips |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/368 |
| work_keys_str_mv | AT yehiaikhalil preparationandcharacterizationofmontelukastsodiumsmltasadualsustainedreleasebuccalstrips |