Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 × 8 Posterior Pole Algorithm of SD-OCT
The purpose of this study was to compare the thickness of all inner and outer macular layers between ocular hypertension (OHT) and early primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT) 8 × 8 posterior pole algorithm (8 × 8 PPA). Fifty-seven eyes of 57 O...
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MDPI AG
2020-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/5/1503 |
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| author | Jose Javier Garcia-Medina Monica del-Rio-Vellosillo Ana Palazon-Cabanes Maria Dolores Pinazo-Duran Vicente Zanon-Moreno Maria Paz Villegas-Perez |
| author_facet | Jose Javier Garcia-Medina Monica del-Rio-Vellosillo Ana Palazon-Cabanes Maria Dolores Pinazo-Duran Vicente Zanon-Moreno Maria Paz Villegas-Perez |
| author_sort | Jose Javier Garcia-Medina |
| collection | DOAJ |
| description | The purpose of this study was to compare the thickness of all inner and outer macular layers between ocular hypertension (OHT) and early primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT) 8 × 8 posterior pole algorithm (8 × 8 PPA). Fifty-seven eyes of 57 OHT individuals and fifty-seven eyes of 57 early POAG patients were included. The thickness of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform and nuclear layer, photoreceptor layer (PRL) and retinal pigment epithelium were obtained in 64 cells for each macular layer and mean thickness of superior and inferior hemispheres was also calculated. Thinning of superior and inferior hemisphere mean thickness in mRNFL, GCL and IPL and thickening of superior and inferior hemisphere mean thickness in PRL and inferior hemisphere in INL were found in early GPAA group. Otherwise, heatmaps representing cell-to-cell comparisons showed thinning patterns in inner retinal layers (except for INL) and thickening patterns in outer retinal layers in GPAA group. We found that 8 × 8 PPA not only allows the detection of significant thinning patterns in inner retinal layers, but also thickening patterns in outer retinal layers when comparing early POAG eyes to OHT eyes. |
| first_indexed | 2024-03-10T19:46:30Z |
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| id | doaj.art-4094e1344c35482a9cd5f8b2d2fab5e8 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T19:46:30Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-4094e1344c35482a9cd5f8b2d2fab5e82023-11-20T00:44:00ZengMDPI AGJournal of Clinical Medicine2077-03832020-05-0195150310.3390/jcm9051503Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 × 8 Posterior Pole Algorithm of SD-OCTJose Javier Garcia-Medina0Monica del-Rio-Vellosillo1Ana Palazon-Cabanes2Maria Dolores Pinazo-Duran3Vicente Zanon-Moreno4Maria Paz Villegas-Perez5Department of Ophthalmology, General University Hospital Morales Meseguer, 30007 Murcia, SpainDepartment of Anesthesiology, University Hospital Virgen de la Arrixaca, 30120 Murcia, SpainDepartment of Ophthalmology, General University Hospital Reina Sofia, 30003 Murcia, SpainOphthalmic Research Unit Santiago Grisolia/FISABIO, 46017 Valencia, SpainArea of Health Sciences, Valencian International University, 46002 Valencia, SpainDepartment of Ophthalmology, General University Hospital Reina Sofia, 30003 Murcia, SpainThe purpose of this study was to compare the thickness of all inner and outer macular layers between ocular hypertension (OHT) and early primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT) 8 × 8 posterior pole algorithm (8 × 8 PPA). Fifty-seven eyes of 57 OHT individuals and fifty-seven eyes of 57 early POAG patients were included. The thickness of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform and nuclear layer, photoreceptor layer (PRL) and retinal pigment epithelium were obtained in 64 cells for each macular layer and mean thickness of superior and inferior hemispheres was also calculated. Thinning of superior and inferior hemisphere mean thickness in mRNFL, GCL and IPL and thickening of superior and inferior hemisphere mean thickness in PRL and inferior hemisphere in INL were found in early GPAA group. Otherwise, heatmaps representing cell-to-cell comparisons showed thinning patterns in inner retinal layers (except for INL) and thickening patterns in outer retinal layers in GPAA group. We found that 8 × 8 PPA not only allows the detection of significant thinning patterns in inner retinal layers, but also thickening patterns in outer retinal layers when comparing early POAG eyes to OHT eyes.https://www.mdpi.com/2077-0383/9/5/1503glaucomaocular hypertensionoptical coherence tomographyposterior pole algorithmmaculalayer |
| spellingShingle | Jose Javier Garcia-Medina Monica del-Rio-Vellosillo Ana Palazon-Cabanes Maria Dolores Pinazo-Duran Vicente Zanon-Moreno Maria Paz Villegas-Perez Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 × 8 Posterior Pole Algorithm of SD-OCT Journal of Clinical Medicine glaucoma ocular hypertension optical coherence tomography posterior pole algorithm macula layer |
| title | Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 × 8 Posterior Pole Algorithm of SD-OCT |
| title_full | Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 × 8 Posterior Pole Algorithm of SD-OCT |
| title_fullStr | Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 × 8 Posterior Pole Algorithm of SD-OCT |
| title_full_unstemmed | Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 × 8 Posterior Pole Algorithm of SD-OCT |
| title_short | Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 × 8 Posterior Pole Algorithm of SD-OCT |
| title_sort | glaucomatous maculopathy thickness differences on inner and outer macular layers between ocular hypertension and early primary open angle glaucoma using 8 8 posterior pole algorithm of sd oct |
| topic | glaucoma ocular hypertension optical coherence tomography posterior pole algorithm macula layer |
| url | https://www.mdpi.com/2077-0383/9/5/1503 |
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