White Tea Intake Abrogates Markers of Streptozotocin-Induced Prediabetes Oxidative Stress in Rat Lungs’
Prediabetes (PrDM) is a prodromal stage of diabetes mellitus (DM) with an increasing prevalence worldwide. During DM progression, individuals gradually develop complications in various organs. However, lungs are suggested to be affected later than other organs, such as the eyes, heart or brain. In t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/13/3894 |
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| author | Ana C. Silveira Luís Rato Pedro Fontes Oliveira Marco G. Alves Branca M. Silva |
| author_facet | Ana C. Silveira Luís Rato Pedro Fontes Oliveira Marco G. Alves Branca M. Silva |
| author_sort | Ana C. Silveira |
| collection | DOAJ |
| description | Prediabetes (PrDM) is a prodromal stage of diabetes mellitus (DM) with an increasing prevalence worldwide. During DM progression, individuals gradually develop complications in various organs. However, lungs are suggested to be affected later than other organs, such as the eyes, heart or brain. In this work, we studied the effects of PrDM on male Wistar rats’ lungs and whether the regular consumption of white tea (WTEA) for 2 months contributes to the improvement of the antioxidant profile of this tissue, namely through improved activity of the first line defense antioxidant enzymes, the total antioxidant capacity and the damages caused in proteins, lipids and histone H2A. Our data shows that PrDM induced a decrease in lung superoxide dismutase and glutathione peroxidase activities and histone H2A levels and an increase in protein nitration and lipid peroxidation. Remarkably, the regular WTEA intake improved lung antioxidant enzymes activity and total antioxidant capacity and re-established the values of protein nitration, lipid peroxidation and histone H2A. Overall, this is the first time that lung is reported as a major target for PrDM. Moreover, it is also the first report showing that WTEA possesses relevant chemical properties against PrDM-induced lung dysfunction. |
| first_indexed | 2024-03-10T10:02:31Z |
| format | Article |
| id | doaj.art-40951de627c4472f81c295c6e3ab44fc |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:02:31Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-40951de627c4472f81c295c6e3ab44fc2023-11-22T01:46:51ZengMDPI AGMolecules1420-30492021-06-012613389410.3390/molecules26133894White Tea Intake Abrogates Markers of Streptozotocin-Induced Prediabetes Oxidative Stress in Rat Lungs’Ana C. Silveira0Luís Rato1Pedro Fontes Oliveira2Marco G. Alves3Branca M. Silva4University of Beira Interior, R. Marquês d’Ávila e Bolama, 6201-001 Covilhã, PortugalUniversity of Beira Interior, R. Marquês d’Ávila e Bolama, 6201-001 Covilhã, PortugalQOPNA & LAQV, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Anatomy, Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo, 4050-313 Porto, PortugalUniversity of Beira Interior, R. Marquês d’Ávila e Bolama, 6201-001 Covilhã, PortugalPrediabetes (PrDM) is a prodromal stage of diabetes mellitus (DM) with an increasing prevalence worldwide. During DM progression, individuals gradually develop complications in various organs. However, lungs are suggested to be affected later than other organs, such as the eyes, heart or brain. In this work, we studied the effects of PrDM on male Wistar rats’ lungs and whether the regular consumption of white tea (WTEA) for 2 months contributes to the improvement of the antioxidant profile of this tissue, namely through improved activity of the first line defense antioxidant enzymes, the total antioxidant capacity and the damages caused in proteins, lipids and histone H2A. Our data shows that PrDM induced a decrease in lung superoxide dismutase and glutathione peroxidase activities and histone H2A levels and an increase in protein nitration and lipid peroxidation. Remarkably, the regular WTEA intake improved lung antioxidant enzymes activity and total antioxidant capacity and re-established the values of protein nitration, lipid peroxidation and histone H2A. Overall, this is the first time that lung is reported as a major target for PrDM. Moreover, it is also the first report showing that WTEA possesses relevant chemical properties against PrDM-induced lung dysfunction.https://www.mdpi.com/1420-3049/26/13/3894white tea<i>Camellia sinensis</i> (L.)antioxidantsoxidative stressprediabeteslung |
| spellingShingle | Ana C. Silveira Luís Rato Pedro Fontes Oliveira Marco G. Alves Branca M. Silva White Tea Intake Abrogates Markers of Streptozotocin-Induced Prediabetes Oxidative Stress in Rat Lungs’ Molecules white tea <i>Camellia sinensis</i> (L.) antioxidants oxidative stress prediabetes lung |
| title | White Tea Intake Abrogates Markers of Streptozotocin-Induced Prediabetes Oxidative Stress in Rat Lungs’ |
| title_full | White Tea Intake Abrogates Markers of Streptozotocin-Induced Prediabetes Oxidative Stress in Rat Lungs’ |
| title_fullStr | White Tea Intake Abrogates Markers of Streptozotocin-Induced Prediabetes Oxidative Stress in Rat Lungs’ |
| title_full_unstemmed | White Tea Intake Abrogates Markers of Streptozotocin-Induced Prediabetes Oxidative Stress in Rat Lungs’ |
| title_short | White Tea Intake Abrogates Markers of Streptozotocin-Induced Prediabetes Oxidative Stress in Rat Lungs’ |
| title_sort | white tea intake abrogates markers of streptozotocin induced prediabetes oxidative stress in rat lungs |
| topic | white tea <i>Camellia sinensis</i> (L.) antioxidants oxidative stress prediabetes lung |
| url | https://www.mdpi.com/1420-3049/26/13/3894 |
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