PIEZO1-Related Physiological and Pathological Processes in CNS: Focus on the Gliomas
PIEZO1 is ubiquitously expressed in cells in different kinds of tissues throughout the body, which can sense physical or mechanical stimuli and translate them into intracellular electrochemical signals to regulate organism functions. In particular, PIEZO1 appears in complex interactive regulatory ne...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/3/883 |
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| author | Rui Hong Dianxu Yang Yao Jing Shiwen Chen Hengli Tian Yang Yang |
| author_facet | Rui Hong Dianxu Yang Yao Jing Shiwen Chen Hengli Tian Yang Yang |
| author_sort | Rui Hong |
| collection | DOAJ |
| description | PIEZO1 is ubiquitously expressed in cells in different kinds of tissues throughout the body, which can sense physical or mechanical stimuli and translate them into intracellular electrochemical signals to regulate organism functions. In particular, PIEZO1 appears in complex interactive regulatory networks as a central node, governing normal and pathological functions in the body. However, the effect and mechanism of the activation or expression of PIEZO1 in diseases of the central nervous system (CNS) remain unclear. On one hand, in CNS diseases, pathophysiological processes in neurons and glial are often accompanied by variations in the mechanical properties of the cellular and extracellular matrix stiffness. The expression of PIEZO1 can therefore be upregulated, in responding to mechanical stimulation, to drive the biological process in cells, which in turns indirectly affects the cellular microenvironment, resulting in alterations of the cellular status. On the other hand, it may have contradictory effects with the change of active patterns and/or subcellular location. This review highlights the biological processes involved with PIEZO1 in CNS cells, with special emphasis on its multiple roles in glioma-associated phenotypes. In conclusion, PIEZO1 can be used as an indicator to assess the malignancy and prognosis of patients with gliomas, as well as a therapeutic target for clinical application following fully exploring the potential mechanism of PIEZO1 in CNS diseases. |
| first_indexed | 2024-03-11T09:49:58Z |
| format | Article |
| id | doaj.art-40984b6fd88a42d59f32b5a2bd64c214 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:49:58Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-40984b6fd88a42d59f32b5a2bd64c2142023-11-16T16:18:32ZengMDPI AGCancers2072-66942023-01-0115388310.3390/cancers15030883PIEZO1-Related Physiological and Pathological Processes in CNS: Focus on the GliomasRui Hong0Dianxu Yang1Yao Jing2Shiwen Chen3Hengli Tian4Yang Yang5Department of Neurosurgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, ChinaDepartment of Neurosurgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, ChinaDepartment of Neurosurgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, ChinaDepartment of Neurosurgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, ChinaDepartment of Neurosurgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, ChinaDepartment of Neurosurgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, ChinaPIEZO1 is ubiquitously expressed in cells in different kinds of tissues throughout the body, which can sense physical or mechanical stimuli and translate them into intracellular electrochemical signals to regulate organism functions. In particular, PIEZO1 appears in complex interactive regulatory networks as a central node, governing normal and pathological functions in the body. However, the effect and mechanism of the activation or expression of PIEZO1 in diseases of the central nervous system (CNS) remain unclear. On one hand, in CNS diseases, pathophysiological processes in neurons and glial are often accompanied by variations in the mechanical properties of the cellular and extracellular matrix stiffness. The expression of PIEZO1 can therefore be upregulated, in responding to mechanical stimulation, to drive the biological process in cells, which in turns indirectly affects the cellular microenvironment, resulting in alterations of the cellular status. On the other hand, it may have contradictory effects with the change of active patterns and/or subcellular location. This review highlights the biological processes involved with PIEZO1 in CNS cells, with special emphasis on its multiple roles in glioma-associated phenotypes. In conclusion, PIEZO1 can be used as an indicator to assess the malignancy and prognosis of patients with gliomas, as well as a therapeutic target for clinical application following fully exploring the potential mechanism of PIEZO1 in CNS diseases.https://www.mdpi.com/2072-6694/15/3/883PIEZO1ion channelmechanotransductiongliomaglia cell |
| spellingShingle | Rui Hong Dianxu Yang Yao Jing Shiwen Chen Hengli Tian Yang Yang PIEZO1-Related Physiological and Pathological Processes in CNS: Focus on the Gliomas Cancers PIEZO1 ion channel mechanotransduction glioma glia cell |
| title | PIEZO1-Related Physiological and Pathological Processes in CNS: Focus on the Gliomas |
| title_full | PIEZO1-Related Physiological and Pathological Processes in CNS: Focus on the Gliomas |
| title_fullStr | PIEZO1-Related Physiological and Pathological Processes in CNS: Focus on the Gliomas |
| title_full_unstemmed | PIEZO1-Related Physiological and Pathological Processes in CNS: Focus on the Gliomas |
| title_short | PIEZO1-Related Physiological and Pathological Processes in CNS: Focus on the Gliomas |
| title_sort | piezo1 related physiological and pathological processes in cns focus on the gliomas |
| topic | PIEZO1 ion channel mechanotransduction glioma glia cell |
| url | https://www.mdpi.com/2072-6694/15/3/883 |
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