Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains
Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death worldwide today. Escalating application of genomic techniques has expedited the identification of increasing number of mutations associated with drug resistance in Mycobacterium tuberculosis. Unfortunately the p...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fcimb.2018.00114/full |
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| author | H. M. Adnan Hameed H. M. Adnan Hameed Md Mahmudul Islam Md Mahmudul Islam Chiranjibi Chhotaray Chiranjibi Chhotaray Changwei Wang Yang Liu Yang Liu Yaoju Tan Xinjie Li Shouyong Tan Vincent Delorme Wing W. Yew Jianxiong Liu Tianyu Zhang Tianyu Zhang |
| author_facet | H. M. Adnan Hameed H. M. Adnan Hameed Md Mahmudul Islam Md Mahmudul Islam Chiranjibi Chhotaray Chiranjibi Chhotaray Changwei Wang Yang Liu Yang Liu Yaoju Tan Xinjie Li Shouyong Tan Vincent Delorme Wing W. Yew Jianxiong Liu Tianyu Zhang Tianyu Zhang |
| author_sort | H. M. Adnan Hameed |
| collection | DOAJ |
| description | Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death worldwide today. Escalating application of genomic techniques has expedited the identification of increasing number of mutations associated with drug resistance in Mycobacterium tuberculosis. Unfortunately the prevalence of bacillary resistance becomes alarming in many parts of the world, with the daunting scenarios of multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and total drug-resistant tuberculosis (TDR-TB), due to number of resistance pathways, alongside some apparently obscure ones. Recent advances in the understanding of the molecular/ genetic basis of drug targets and drug resistance mechanisms have been steadily made. Intriguing findings through whole genome sequencing and other molecular approaches facilitate the further understanding of biology and pathology of M. tuberculosis for the development of new therapeutics to meet the immense challenge of global health. |
| first_indexed | 2024-12-10T14:08:31Z |
| format | Article |
| id | doaj.art-40986f324a5947aba9e47a6b50fe8a4c |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-10T14:08:31Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-40986f324a5947aba9e47a6b50fe8a4c2022-12-22T01:45:34ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882018-04-01810.3389/fcimb.2018.00114304196Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis StrainsH. M. Adnan Hameed0H. M. Adnan Hameed1Md Mahmudul Islam2Md Mahmudul Islam3Chiranjibi Chhotaray4Chiranjibi Chhotaray5Changwei Wang6Yang Liu7Yang Liu8Yaoju Tan9Xinjie Li10Shouyong Tan11Vincent Delorme12Wing W. Yew13Jianxiong Liu14Tianyu Zhang15Tianyu Zhang16State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, ChinaState Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, ChinaInstitute of Health Sciences, Anhui University, Hefei, ChinaState Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, ChinaState Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, ChinaState Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, ChinaTuberculosis Research Laboratory, Institut Pasteur Korea, Seongnam-si, South KoreaStanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, ChinaState Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, ChinaState Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaTuberculosis (TB) is a formidable infectious disease that remains a major cause of death worldwide today. Escalating application of genomic techniques has expedited the identification of increasing number of mutations associated with drug resistance in Mycobacterium tuberculosis. Unfortunately the prevalence of bacillary resistance becomes alarming in many parts of the world, with the daunting scenarios of multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and total drug-resistant tuberculosis (TDR-TB), due to number of resistance pathways, alongside some apparently obscure ones. Recent advances in the understanding of the molecular/ genetic basis of drug targets and drug resistance mechanisms have been steadily made. Intriguing findings through whole genome sequencing and other molecular approaches facilitate the further understanding of biology and pathology of M. tuberculosis for the development of new therapeutics to meet the immense challenge of global health.http://journal.frontiersin.org/article/10.3389/fcimb.2018.00114/fullMycobacterium tuberculosisdrug resistancemolecularcomorbiditiestherapeuticdrug targets |
| spellingShingle | H. M. Adnan Hameed H. M. Adnan Hameed Md Mahmudul Islam Md Mahmudul Islam Chiranjibi Chhotaray Chiranjibi Chhotaray Changwei Wang Yang Liu Yang Liu Yaoju Tan Xinjie Li Shouyong Tan Vincent Delorme Wing W. Yew Jianxiong Liu Tianyu Zhang Tianyu Zhang Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains Frontiers in Cellular and Infection Microbiology Mycobacterium tuberculosis drug resistance molecular comorbidities therapeutic drug targets |
| title | Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains |
| title_full | Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains |
| title_fullStr | Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains |
| title_full_unstemmed | Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains |
| title_short | Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains |
| title_sort | molecular targets related drug resistance mechanisms in mdr xdr and tdr mycobacterium tuberculosis strains |
| topic | Mycobacterium tuberculosis drug resistance molecular comorbidities therapeutic drug targets |
| url | http://journal.frontiersin.org/article/10.3389/fcimb.2018.00114/full |
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