Analysis of factors associated with short-term elevation of intraocular pressure after Conbercept intravitreal injection
AIM:To investigate the factors associated with short-term elevation of intraocular pressure(IOP)after conbercept intravitreal injection. METHODS:This study was a clinical prospective observational study. It enrolled in 269 eyes of 269 patients who were diagnosed retinopathy, and all patients receive...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2022-05-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2022/5/202205011.pdf |
| _version_ | 1817988906336911360 |
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| author | Yue Wu Li-Li Jiang Chun-Sheng Shi Bo Jiang |
| author_facet | Yue Wu Li-Li Jiang Chun-Sheng Shi Bo Jiang |
| author_sort | Yue Wu |
| collection | DOAJ |
| description | AIM:To investigate the factors associated with short-term elevation of intraocular pressure(IOP)after conbercept intravitreal injection. METHODS:This study was a clinical prospective observational study. It enrolled in 269 eyes of 269 patients who were diagnosed retinopathy, and all patients receive conbercept intravitreal injection. Among them, 143 were males and 126 were females. There were 201 cases of age-related macular degeneration(ARMD)and 68 cases of other retinopathy patients. The mean age was 62.86±11.74 years. Non-contact pneumatic tonometer was used to measure the IOP of the patients before, 10, 30min, 2 and 4h after injection. The group was divided according to the IOP elevation 10min after injection. The IOP elevation 10 mmHg and above was defined as the IOP elevation group, and the IOP elevation less than 10 mmHg was defined as the IOP stable group. Multivariate Logistic regression analysis was used to analyze the differences between the two groups.RESULTS:The average IOP of patients at 10, 30min, 2 and 4h after injection was 24.1, 20.2, 19.5 and 16.9 mmHg, respectively. The average IOP at each time point after injection was 6.7, 3.1, 1.7 and 0.5 mmHg higher than that before injection. Among them, 56 cases of increased IOP, 213 cases of stable IOP. There were no significant differences in age, best corrected visual acuity(BCVA), gender, eye side and disease type between two groups(all P>0.05). There were statistically significant differences in the number of injection(Z=-4.389, P=0.012), IOP before injection and IOP at each time point after injection(t=-5.343, -10.467, -8.933, -6.124, -4.635, all P<0.01). Multivariate Logistic regression analysis showed that baseline IOP was positively correlated with IOP increase 10min after injection(B=-0.913, OR=0.521, 95%CI: 0.211-0.694, P=0.011).CONCLUSION: The higher the baseline IOP, the higher risk of elevated IOP after injection. The factor associated with a short-term increase in IOP after intravitreal injection of conbercept was baseline IOP. The number of injection may be another risk factor. |
| first_indexed | 2024-04-14T00:40:22Z |
| format | Article |
| id | doaj.art-4098922f0f4249f6a4042814dd9e44be |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-04-14T00:40:22Z |
| publishDate | 2022-05-01 |
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| series | Guoji Yanke Zazhi |
| spelling | doaj.art-4098922f0f4249f6a4042814dd9e44be2022-12-22T02:22:13ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232022-05-0122575275610.3980/j.issn.1672-5123.2022.5.11202205011Analysis of factors associated with short-term elevation of intraocular pressure after Conbercept intravitreal injectionYue Wu0Li-Li Jiang1Chun-Sheng Shi2Bo Jiang3Department of Ophthalmology, Anhui No.2 Provincial People's Hospital, Hefei 230041, Anhui Province, ChinaDepartment of Ophthalmology, Anhui No.2 Provincial People's Hospital, Hefei 230041, Anhui Province, ChinaDepartment of Ophthalmology, Anhui No.2 Provincial People's Hospital, Hefei 230041, Anhui Province, ChinaDepartment of Ophthalmology, Anhui No.2 Provincial People's Hospital, Hefei 230041, Anhui Province, ChinaAIM:To investigate the factors associated with short-term elevation of intraocular pressure(IOP)after conbercept intravitreal injection. METHODS:This study was a clinical prospective observational study. It enrolled in 269 eyes of 269 patients who were diagnosed retinopathy, and all patients receive conbercept intravitreal injection. Among them, 143 were males and 126 were females. There were 201 cases of age-related macular degeneration(ARMD)and 68 cases of other retinopathy patients. The mean age was 62.86±11.74 years. Non-contact pneumatic tonometer was used to measure the IOP of the patients before, 10, 30min, 2 and 4h after injection. The group was divided according to the IOP elevation 10min after injection. The IOP elevation 10 mmHg and above was defined as the IOP elevation group, and the IOP elevation less than 10 mmHg was defined as the IOP stable group. Multivariate Logistic regression analysis was used to analyze the differences between the two groups.RESULTS:The average IOP of patients at 10, 30min, 2 and 4h after injection was 24.1, 20.2, 19.5 and 16.9 mmHg, respectively. The average IOP at each time point after injection was 6.7, 3.1, 1.7 and 0.5 mmHg higher than that before injection. Among them, 56 cases of increased IOP, 213 cases of stable IOP. There were no significant differences in age, best corrected visual acuity(BCVA), gender, eye side and disease type between two groups(all P>0.05). There were statistically significant differences in the number of injection(Z=-4.389, P=0.012), IOP before injection and IOP at each time point after injection(t=-5.343, -10.467, -8.933, -6.124, -4.635, all P<0.01). Multivariate Logistic regression analysis showed that baseline IOP was positively correlated with IOP increase 10min after injection(B=-0.913, OR=0.521, 95%CI: 0.211-0.694, P=0.011).CONCLUSION: The higher the baseline IOP, the higher risk of elevated IOP after injection. The factor associated with a short-term increase in IOP after intravitreal injection of conbercept was baseline IOP. The number of injection may be another risk factor.http://ies.ijo.cn/cn_publish/2022/5/202205011.pdfconberceptintravitreal injectionocular hypertensioninfluencing factor |
| spellingShingle | Yue Wu Li-Li Jiang Chun-Sheng Shi Bo Jiang Analysis of factors associated with short-term elevation of intraocular pressure after Conbercept intravitreal injection Guoji Yanke Zazhi conbercept intravitreal injection ocular hypertension influencing factor |
| title | Analysis of factors associated with short-term elevation of intraocular pressure after Conbercept intravitreal injection |
| title_full | Analysis of factors associated with short-term elevation of intraocular pressure after Conbercept intravitreal injection |
| title_fullStr | Analysis of factors associated with short-term elevation of intraocular pressure after Conbercept intravitreal injection |
| title_full_unstemmed | Analysis of factors associated with short-term elevation of intraocular pressure after Conbercept intravitreal injection |
| title_short | Analysis of factors associated with short-term elevation of intraocular pressure after Conbercept intravitreal injection |
| title_sort | analysis of factors associated with short term elevation of intraocular pressure after conbercept intravitreal injection |
| topic | conbercept intravitreal injection ocular hypertension influencing factor |
| url | http://ies.ijo.cn/cn_publish/2022/5/202205011.pdf |
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