Alternative Splicing as a Target for Cancer Treatment
Alternative splicing is a key mechanism determinant for gene expression in metazoan. During alternative splicing, non-coding sequences are removed to generate different mature messenger RNAs due to a combination of sequence elements and cellular factors that contribute to splicing regulation. A diff...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/19/2/545 |
| _version_ | 1811204033619165184 |
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| author | Nancy Martinez-Montiel Nora Hilda Rosas-Murrieta Maricruz Anaya Ruiz Eduardo Monjaraz-Guzman Rebeca Martinez-Contreras |
| author_facet | Nancy Martinez-Montiel Nora Hilda Rosas-Murrieta Maricruz Anaya Ruiz Eduardo Monjaraz-Guzman Rebeca Martinez-Contreras |
| author_sort | Nancy Martinez-Montiel |
| collection | DOAJ |
| description | Alternative splicing is a key mechanism determinant for gene expression in metazoan. During alternative splicing, non-coding sequences are removed to generate different mature messenger RNAs due to a combination of sequence elements and cellular factors that contribute to splicing regulation. A different combination of splicing sites, exonic or intronic sequences, mutually exclusive exons or retained introns could be selected during alternative splicing to generate different mature mRNAs that could in turn produce distinct protein products. Alternative splicing is the main source of protein diversity responsible for 90% of human gene expression, and it has recently become a hallmark for cancer with a full potential as a prognostic and therapeutic tool. Currently, more than 15,000 alternative splicing events have been associated to different aspects of cancer biology, including cell proliferation and invasion, apoptosis resistance and susceptibility to different chemotherapeutic drugs. Here, we present well established and newly discovered splicing events that occur in different cancer-related genes, their modification by several approaches and the current status of key tools developed to target alternative splicing with diagnostic and therapeutic purposes. |
| first_indexed | 2024-04-12T03:06:08Z |
| format | Article |
| id | doaj.art-4099191dd79940bf996b50539624c928 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T03:06:08Z |
| publishDate | 2018-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4099191dd79940bf996b50539624c9282022-12-22T03:50:30ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-02-0119254510.3390/ijms19020545ijms19020545Alternative Splicing as a Target for Cancer TreatmentNancy Martinez-Montiel0Nora Hilda Rosas-Murrieta1Maricruz Anaya Ruiz2Eduardo Monjaraz-Guzman3Rebeca Martinez-Contreras4Centro de Investigaciones en Ciencias Microbiológicas, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla 72470, MexicoFacultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla 72470, MexicoCentro de Investigación Biomédica de Oriente (CIBIOR), Instituto Mexicano del Seguro Social (IMSS), Metepec, Puebla 74360, MexicoInstituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla 72470, MexicoCentro de Investigaciones en Ciencias Microbiológicas, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla 72470, MexicoAlternative splicing is a key mechanism determinant for gene expression in metazoan. During alternative splicing, non-coding sequences are removed to generate different mature messenger RNAs due to a combination of sequence elements and cellular factors that contribute to splicing regulation. A different combination of splicing sites, exonic or intronic sequences, mutually exclusive exons or retained introns could be selected during alternative splicing to generate different mature mRNAs that could in turn produce distinct protein products. Alternative splicing is the main source of protein diversity responsible for 90% of human gene expression, and it has recently become a hallmark for cancer with a full potential as a prognostic and therapeutic tool. Currently, more than 15,000 alternative splicing events have been associated to different aspects of cancer biology, including cell proliferation and invasion, apoptosis resistance and susceptibility to different chemotherapeutic drugs. Here, we present well established and newly discovered splicing events that occur in different cancer-related genes, their modification by several approaches and the current status of key tools developed to target alternative splicing with diagnostic and therapeutic purposes.http://www.mdpi.com/1422-0067/19/2/545alternative splicingcancerdiagnosistherapeutics |
| spellingShingle | Nancy Martinez-Montiel Nora Hilda Rosas-Murrieta Maricruz Anaya Ruiz Eduardo Monjaraz-Guzman Rebeca Martinez-Contreras Alternative Splicing as a Target for Cancer Treatment International Journal of Molecular Sciences alternative splicing cancer diagnosis therapeutics |
| title | Alternative Splicing as a Target for Cancer Treatment |
| title_full | Alternative Splicing as a Target for Cancer Treatment |
| title_fullStr | Alternative Splicing as a Target for Cancer Treatment |
| title_full_unstemmed | Alternative Splicing as a Target for Cancer Treatment |
| title_short | Alternative Splicing as a Target for Cancer Treatment |
| title_sort | alternative splicing as a target for cancer treatment |
| topic | alternative splicing cancer diagnosis therapeutics |
| url | http://www.mdpi.com/1422-0067/19/2/545 |
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