Incidence of cancers in patients with atherosclerotic cardiovascular diseases
Background: To address a clinical impact of atherosclerotic cardiovascular diseases (CVD) on cancer developments, we investigated an issue whether any difference in an incidence of cancers is present between patients with atherosclerotic CVD and those with non-atherosclerotic CVD. Methods: Of a tota...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-12-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906717300453 |
| _version_ | 1811240005127897088 |
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| author | Makoto Suzuki Hitonobu Tomoike Tetsuya Sumiyoshi Yuji Nagatomo Toru Hosoda Masatoshi Nagayama Yuichi Ishikawa Tomohiro Sawa Satoshi Iimuro Tsutomu Yoshikawa Saichi Hosoda |
| author_facet | Makoto Suzuki Hitonobu Tomoike Tetsuya Sumiyoshi Yuji Nagatomo Toru Hosoda Masatoshi Nagayama Yuichi Ishikawa Tomohiro Sawa Satoshi Iimuro Tsutomu Yoshikawa Saichi Hosoda |
| author_sort | Makoto Suzuki |
| collection | DOAJ |
| description | Background: To address a clinical impact of atherosclerotic cardiovascular diseases (CVD) on cancer developments, we investigated an issue whether any difference in an incidence of cancers is present between patients with atherosclerotic CVD and those with non-atherosclerotic CVD.
Methods: Of a total of 32,095 consecutive patients with acquired CVD enrolled in the Sakakibara Health Integrative Profile cohort study, we segregated patients based on a presence of atherosclerotic or non-atherosclerotic CVD to investigate an incidence of cancers and mortality. We also evaluated an incidence of cancers in patients with a singular presence versus a plural presence of atherosclerotic CVD. Atherosclerotic CVD included coronary artery diseases, aortic diseases and peripheral artery diseases. Non-atherosclerotic CVD were any acquired CVD except atherosclerotic CVD.
Results: During a median follow-up of 1020 days (interquartile range, 665–1340 days), an incidence of cancers (5% vs. 2%, p = 0.0001) and overall mortality (6% vs. 3%, p = 0.0001) were more than two-fold higher in 10,592 patients with atherosclerotic CVD than in 21,503 patients with non-atherosclerotic CVD. A presence of atherosclerotic CVD (hazard ratio 1.372 with 95% confidence interval 1.199–1.569) was independently associated with an incidence of cancers. In patients with atherosclerotic CVD, 61 of 640 patients with a plural presence and 470 of 9932 patients with a singular presence developed cancers (9% vs. 5%, p = 0.0001). An incremental risk of death was found according to a presence of atherosclerotic CVD, cancers, and both of them (all p = 0.0001).
Conclusions: A presence of atherosclerotic CVD itself may have a potential risk for cancer developments.
Trial registration: ClinicalTrials.gov. number, NCT03005834 |
| first_indexed | 2024-04-12T13:11:41Z |
| format | Article |
| id | doaj.art-409a714863f34ad6aa8acad22dfec484 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-04-12T13:11:41Z |
| publishDate | 2017-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-409a714863f34ad6aa8acad22dfec4842022-12-22T03:31:50ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672017-12-0117C111610.1016/j.ijcha.2017.08.004Incidence of cancers in patients with atherosclerotic cardiovascular diseasesMakoto Suzuki0Hitonobu Tomoike1Tetsuya Sumiyoshi2Yuji Nagatomo3Toru Hosoda4Masatoshi Nagayama5Yuichi Ishikawa6Tomohiro Sawa7Satoshi Iimuro8Tsutomu Yoshikawa9Saichi Hosoda10Department of Cardiology, Sakakibara Heart Institute, Tokyo, JapanDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, JapanDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, JapanDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, JapanDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, JapanDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, JapanDivision of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, JapanMedical Information and System Research Center, Teikyo University, Tokyo, JapanTeikyo Academic Research Center, Teikyo University, Tokyo, JapanDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, JapanDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, JapanBackground: To address a clinical impact of atherosclerotic cardiovascular diseases (CVD) on cancer developments, we investigated an issue whether any difference in an incidence of cancers is present between patients with atherosclerotic CVD and those with non-atherosclerotic CVD. Methods: Of a total of 32,095 consecutive patients with acquired CVD enrolled in the Sakakibara Health Integrative Profile cohort study, we segregated patients based on a presence of atherosclerotic or non-atherosclerotic CVD to investigate an incidence of cancers and mortality. We also evaluated an incidence of cancers in patients with a singular presence versus a plural presence of atherosclerotic CVD. Atherosclerotic CVD included coronary artery diseases, aortic diseases and peripheral artery diseases. Non-atherosclerotic CVD were any acquired CVD except atherosclerotic CVD. Results: During a median follow-up of 1020 days (interquartile range, 665–1340 days), an incidence of cancers (5% vs. 2%, p = 0.0001) and overall mortality (6% vs. 3%, p = 0.0001) were more than two-fold higher in 10,592 patients with atherosclerotic CVD than in 21,503 patients with non-atherosclerotic CVD. A presence of atherosclerotic CVD (hazard ratio 1.372 with 95% confidence interval 1.199–1.569) was independently associated with an incidence of cancers. In patients with atherosclerotic CVD, 61 of 640 patients with a plural presence and 470 of 9932 patients with a singular presence developed cancers (9% vs. 5%, p = 0.0001). An incremental risk of death was found according to a presence of atherosclerotic CVD, cancers, and both of them (all p = 0.0001). Conclusions: A presence of atherosclerotic CVD itself may have a potential risk for cancer developments. Trial registration: ClinicalTrials.gov. number, NCT03005834http://www.sciencedirect.com/science/article/pii/S2352906717300453Atherosclerotic cardiovascular diseasesCancersMortalityThe SHIP cohort study |
| spellingShingle | Makoto Suzuki Hitonobu Tomoike Tetsuya Sumiyoshi Yuji Nagatomo Toru Hosoda Masatoshi Nagayama Yuichi Ishikawa Tomohiro Sawa Satoshi Iimuro Tsutomu Yoshikawa Saichi Hosoda Incidence of cancers in patients with atherosclerotic cardiovascular diseases International Journal of Cardiology: Heart & Vasculature Atherosclerotic cardiovascular diseases Cancers Mortality The SHIP cohort study |
| title | Incidence of cancers in patients with atherosclerotic cardiovascular diseases |
| title_full | Incidence of cancers in patients with atherosclerotic cardiovascular diseases |
| title_fullStr | Incidence of cancers in patients with atherosclerotic cardiovascular diseases |
| title_full_unstemmed | Incidence of cancers in patients with atherosclerotic cardiovascular diseases |
| title_short | Incidence of cancers in patients with atherosclerotic cardiovascular diseases |
| title_sort | incidence of cancers in patients with atherosclerotic cardiovascular diseases |
| topic | Atherosclerotic cardiovascular diseases Cancers Mortality The SHIP cohort study |
| url | http://www.sciencedirect.com/science/article/pii/S2352906717300453 |
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