Accelerated brain aging in major depressive disorder and antidepressant treatment response: A CAN-BIND report
Objectives: Previous studies suggest that major depressive disorder (MDD) may be associated with volumetric indications of accelerated brain aging. This study investigated neuroanatomical signs of accelerated aging in MDD and evaluated whether a brain age gap is associated with antidepressant respon...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158221003089 |
| _version_ | 1818342984348860416 |
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| author | Pedro L. Ballester Jee Su Suh Nikita Nogovitsyn Stefanie Hassel Stephen C. Strother Stephen R. Arnott Luciano Minuzzi Roberto B. Sassi Raymond W. Lam Roumen Milev Daniel J. Müller Valerie H. Taylor Sidney H. Kennedy Benicio N. Frey |
| author_facet | Pedro L. Ballester Jee Su Suh Nikita Nogovitsyn Stefanie Hassel Stephen C. Strother Stephen R. Arnott Luciano Minuzzi Roberto B. Sassi Raymond W. Lam Roumen Milev Daniel J. Müller Valerie H. Taylor Sidney H. Kennedy Benicio N. Frey |
| author_sort | Pedro L. Ballester |
| collection | DOAJ |
| description | Objectives: Previous studies suggest that major depressive disorder (MDD) may be associated with volumetric indications of accelerated brain aging. This study investigated neuroanatomical signs of accelerated aging in MDD and evaluated whether a brain age gap is associated with antidepressant response. Methods: Individuals in a major depressive episode received escitalopram treatment (10–20 mg/d) for 8 weeks. Depression severity was assessed at baseline and at weeks 8 and 16 using the Montgomery-Asberg Depression Rating Scale (MADRS). Response to treatment was characterized by a significant reduction in the MADRS (≥50%). Nonresponders received adjunctive aripiprazole treatment (2–10 mg/d) for a further 8 weeks. The brain-predicted age difference (brain-PAD) at baseline was determined using machine learning methods trained on 3377 healthy individuals from seven publicly available datasets. The model used features from all brain regions extracted from structural magnetic resonance imaging data. Results: Brain-PAD was significantly higher in older MDD participants compared to younger MDD participants [t(147.35) = -2.35, p < 0.03]. BMI was significantly associated with brain-PAD in the MDD group [r(155) = 0.19, p < 0.03]. Response to treatment was not significantly associated with brain-PAD. Conclusion: We found an elevated brain age gap in older individuals with MDD. Brain-PAD was not associated with overall treatment response to escitalopram monotherapy or escitalopram plus adjunctive aripiprazole. |
| first_indexed | 2024-12-13T16:23:22Z |
| format | Article |
| id | doaj.art-409bfb52a9a64e5faab9e1953af4c00b |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-13T16:23:22Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-409bfb52a9a64e5faab9e1953af4c00b2022-12-21T23:38:39ZengElsevierNeuroImage: Clinical2213-15822021-01-0132102864Accelerated brain aging in major depressive disorder and antidepressant treatment response: A CAN-BIND reportPedro L. Ballester0Jee Su Suh1Nikita Nogovitsyn2Stefanie Hassel3Stephen C. Strother4Stephen R. Arnott5Luciano Minuzzi6Roberto B. Sassi7Raymond W. Lam8Roumen Milev9Daniel J. Müller10Valerie H. Taylor11Sidney H. Kennedy12Benicio N. Frey13Neuroscience Graduate Program, McMaster University, Hamilton, ON, CanadaNeuroscience Graduate Program, McMaster University, Hamilton, ON, CanadaMood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, CanadaDepartment of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaRotman Research Institute, Baycrest, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, ON, CanadaRotman Research Institute, Baycrest, Toronto, ON, CanadaMood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, CanadaMood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, CanadaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, CanadaDepartments of Psychiatry and Psychology, Queen’s University, and Providence Care, Kingston, ON, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CanadaDepartment of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaInstitute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Centre for Mental Health, University Health Network, Toronto, ON, Canada; Krembil Research Institute, University Health Network, Toronto, ON, Canada; Centre for Depression and Suicide Studies, and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, CanadaMood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada; Corresponding author at: 100 West 5th Street, Suite C124, Hamilton, ON L8N 3K7, Canada.Objectives: Previous studies suggest that major depressive disorder (MDD) may be associated with volumetric indications of accelerated brain aging. This study investigated neuroanatomical signs of accelerated aging in MDD and evaluated whether a brain age gap is associated with antidepressant response. Methods: Individuals in a major depressive episode received escitalopram treatment (10–20 mg/d) for 8 weeks. Depression severity was assessed at baseline and at weeks 8 and 16 using the Montgomery-Asberg Depression Rating Scale (MADRS). Response to treatment was characterized by a significant reduction in the MADRS (≥50%). Nonresponders received adjunctive aripiprazole treatment (2–10 mg/d) for a further 8 weeks. The brain-predicted age difference (brain-PAD) at baseline was determined using machine learning methods trained on 3377 healthy individuals from seven publicly available datasets. The model used features from all brain regions extracted from structural magnetic resonance imaging data. Results: Brain-PAD was significantly higher in older MDD participants compared to younger MDD participants [t(147.35) = -2.35, p < 0.03]. BMI was significantly associated with brain-PAD in the MDD group [r(155) = 0.19, p < 0.03]. Response to treatment was not significantly associated with brain-PAD. Conclusion: We found an elevated brain age gap in older individuals with MDD. Brain-PAD was not associated with overall treatment response to escitalopram monotherapy or escitalopram plus adjunctive aripiprazole.http://www.sciencedirect.com/science/article/pii/S2213158221003089Treatment responseMajor depressive disorderBrain ageMachine learning |
| spellingShingle | Pedro L. Ballester Jee Su Suh Nikita Nogovitsyn Stefanie Hassel Stephen C. Strother Stephen R. Arnott Luciano Minuzzi Roberto B. Sassi Raymond W. Lam Roumen Milev Daniel J. Müller Valerie H. Taylor Sidney H. Kennedy Benicio N. Frey Accelerated brain aging in major depressive disorder and antidepressant treatment response: A CAN-BIND report NeuroImage: Clinical Treatment response Major depressive disorder Brain age Machine learning |
| title | Accelerated brain aging in major depressive disorder and antidepressant treatment response: A CAN-BIND report |
| title_full | Accelerated brain aging in major depressive disorder and antidepressant treatment response: A CAN-BIND report |
| title_fullStr | Accelerated brain aging in major depressive disorder and antidepressant treatment response: A CAN-BIND report |
| title_full_unstemmed | Accelerated brain aging in major depressive disorder and antidepressant treatment response: A CAN-BIND report |
| title_short | Accelerated brain aging in major depressive disorder and antidepressant treatment response: A CAN-BIND report |
| title_sort | accelerated brain aging in major depressive disorder and antidepressant treatment response a can bind report |
| topic | Treatment response Major depressive disorder Brain age Machine learning |
| url | http://www.sciencedirect.com/science/article/pii/S2213158221003089 |
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