RNA sequencing identifies novel regulated IRE1-dependent decay targets that affect multiple myeloma survival and proliferation

RNA sequencing identifies novel regulated IRE1-dependent decay targets that affect multiple myeloma survival and proliferation

Abstract Background IRE1 is an unfolded protein response (UPR) sensor with kinase and endonuclease activity. It plays a central role in the endoplasmic reticulum (ER) stress response through unconventional splicing of XBP1 mRNA and regulated IRE1-dependent decay (RIDD). Multiple myeloma (MM) cells a...

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Main Authors: Dalia Quwaider, Luis A. Corchete, Marta Martín-Izquierdo, Jesús M. Hernández-Sánchez, Elizabeta A. Rojas, Ignacio J. Cardona-Benavides, Ramón García-Sanz, Ana B. Herrero, Norma C. Gutiérrez
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Experimental Hematology & Oncology
Subjects:
ER stress
UPR
IRE1
RIDD
Multiple myeloma
Online Access:https://doi.org/10.1186/s40164-022-00271-4

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