Differential effects of age, sex and dexamethasone therapy on ACE2/TMPRSS2 expression and susceptibility to SARS-CoV-2 infection

Differential effects of age, sex and dexamethasone therapy on ACE2/TMPRSS2 expression and susceptibility to SARS-CoV-2 infection

ACE2 and TMPRSS2 are crucial for SARS-CoV-2 entry into the cell. Although ACE2 facilitates viral entry, its loss leads to promoting the devastating clinical symptoms of COVID-19 disease. Thus, enhanced ACE2/TMPRSS2 expression is likely to increase predisposition of target cells to SARS-CoV-2 infecti...

Full description

Bibliographic Details
Main Authors: Shima Shahbaz, Olaide Oyegbami, Suguru Saito, Mohammed Osman, Wendy Sligl, Shokrollah Elahi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
COVID-19
ACE2
TMPRSS2
dexamethasone
age
sex
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1021928/full

Similar Items

Similar Items