The Relationship of Plasma Zinc Concentration and Hepatic Encephalopathy in Patients with Cirrhosis
Background: Zinc deficiency is prevalent in Iran. Regarding the effect of zinc element on pathogenesis of cirrhosis and hepatic encephalopathy, the present study has been designed to assess the zinc deficiency in patients with cirrhosis, with and without hepatic encephalopathy. Methods: This descri...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2014-11-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/3747 |
| _version_ | 1827845797130010624 |
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| author | Rahmatollah Rafiei Ahmad Sobhani Mehrgu Amraee Zahra Torabi Mohammad Majlesi |
| author_facet | Rahmatollah Rafiei Ahmad Sobhani Mehrgu Amraee Zahra Torabi Mohammad Majlesi |
| author_sort | Rahmatollah Rafiei |
| collection | DOAJ |
| description | Background: Zinc deficiency is prevalent in Iran. Regarding the effect of zinc element on pathogenesis of cirrhosis and hepatic encephalopathy, the present study has been designed to assess the zinc deficiency in patients with cirrhosis, with and without hepatic encephalopathy.
Methods: This descriptive-analytical cross-sectional study was done in internal ward of Shariati Hospital, Isfahan, Iran, in 2011. 80 patients with cirrhosis, with any etiology, were chosen and divided in two groups of with and without hepatic encephalopathy. They were examined for plasma zinc concentration. The recorded data was analyzed via Stata11 software.
Findings: 80 patients with cirrhosis with the mean (± standard deviation) age of 50.97 ± 14.51 years were evaluated. There were 44 men (55 percent) and 36 women (45 percent). The mean (± standard deviation) concentration of plasma zinc was 87.50 ± 27.03 µg/dl. The plasma zinc concentration was low in 26.25 percent. The mean (± standard deviation) concentration of plasma zinc in patients with and without hepatic encephalopathy was 75.10 ± 23.9 and 104.00 ± 23.10 µg/dl, respectively, with significant statistically difference (P < 0.05). No relationships were found between the age, gender, and serum zinc concentration (P > 0.05).
Conclusion: The plasma zinc concentration was low in patients with cirrhosis, especially in those with hepatic encephalopathy; therefore, measurement of plasma zinc concentration should be considered for patients with cirrhosis, especially in those with hepatic encephalopathy to do the suitable treatment. |
| first_indexed | 2024-03-12T09:03:30Z |
| format | Article |
| id | doaj.art-409e584578284fa48cd2cf6e75e06d30 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T09:03:30Z |
| publishDate | 2014-11-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-409e584578284fa48cd2cf6e75e06d302023-09-02T15:28:55ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2014-11-0132303157715841703The Relationship of Plasma Zinc Concentration and Hepatic Encephalopathy in Patients with CirrhosisRahmatollah Rafiei0Ahmad Sobhani1Mehrgu Amraee2Zahra Torabi3Mohammad Majlesi4Assistant Professor, Department of Internal Medicine, School of Medicine, Islamic Azad University, Najafabad Branch, Isfahan, IranAssistant Professor, Department of Internal Medicine, School of Medicine, Islamic Azad University, Najafabad Branch, Isfahan, IranStudent of Medicine, School of Medicine, Islamic Azad University, Najafabad Branch, Isfahan, IranGeneral Practitioner, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Internal Medicine, School of Medicine, Islamic Azad University, Najafabad Branch, Isfahan, IranBackground: Zinc deficiency is prevalent in Iran. Regarding the effect of zinc element on pathogenesis of cirrhosis and hepatic encephalopathy, the present study has been designed to assess the zinc deficiency in patients with cirrhosis, with and without hepatic encephalopathy. Methods: This descriptive-analytical cross-sectional study was done in internal ward of Shariati Hospital, Isfahan, Iran, in 2011. 80 patients with cirrhosis, with any etiology, were chosen and divided in two groups of with and without hepatic encephalopathy. They were examined for plasma zinc concentration. The recorded data was analyzed via Stata11 software. Findings: 80 patients with cirrhosis with the mean (± standard deviation) age of 50.97 ± 14.51 years were evaluated. There were 44 men (55 percent) and 36 women (45 percent). The mean (± standard deviation) concentration of plasma zinc was 87.50 ± 27.03 µg/dl. The plasma zinc concentration was low in 26.25 percent. The mean (± standard deviation) concentration of plasma zinc in patients with and without hepatic encephalopathy was 75.10 ± 23.9 and 104.00 ± 23.10 µg/dl, respectively, with significant statistically difference (P < 0.05). No relationships were found between the age, gender, and serum zinc concentration (P > 0.05). Conclusion: The plasma zinc concentration was low in patients with cirrhosis, especially in those with hepatic encephalopathy; therefore, measurement of plasma zinc concentration should be considered for patients with cirrhosis, especially in those with hepatic encephalopathy to do the suitable treatment.http://jims.mui.ac.ir/index.php/jims/article/view/3747CirrhosisHepatic encephalopathyZinc |
| spellingShingle | Rahmatollah Rafiei Ahmad Sobhani Mehrgu Amraee Zahra Torabi Mohammad Majlesi The Relationship of Plasma Zinc Concentration and Hepatic Encephalopathy in Patients with Cirrhosis مجله دانشکده پزشکی اصفهان Cirrhosis Hepatic encephalopathy Zinc |
| title | The Relationship of Plasma Zinc Concentration and Hepatic Encephalopathy in Patients with Cirrhosis |
| title_full | The Relationship of Plasma Zinc Concentration and Hepatic Encephalopathy in Patients with Cirrhosis |
| title_fullStr | The Relationship of Plasma Zinc Concentration and Hepatic Encephalopathy in Patients with Cirrhosis |
| title_full_unstemmed | The Relationship of Plasma Zinc Concentration and Hepatic Encephalopathy in Patients with Cirrhosis |
| title_short | The Relationship of Plasma Zinc Concentration and Hepatic Encephalopathy in Patients with Cirrhosis |
| title_sort | relationship of plasma zinc concentration and hepatic encephalopathy in patients with cirrhosis |
| topic | Cirrhosis Hepatic encephalopathy Zinc |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/3747 |
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