Baicalein inhibits neuroapoptosis via pathways in sevoflurane induced rats
Baicalein, a bioactive flavonoid was explored for its capability to attenuate sevoflurane induced neuronal apoptosis and to improve behavioural and cognitive impairments. Sevoflurane is a frequently used inhalation anesthetic in neonates and children. Neonatal sevoflurane exposure causes widespread...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2018-07-01
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| Series: | Translational Neuroscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/tnsci-2018-0015 |
| _version_ | 1819016262673498112 |
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| author | Wang Si Zhou Yu |
| author_facet | Wang Si Zhou Yu |
| author_sort | Wang Si |
| collection | DOAJ |
| description | Baicalein, a bioactive flavonoid was explored for its capability to attenuate sevoflurane induced neuronal apoptosis and to improve behavioural and cognitive impairments. Sevoflurane is a frequently used inhalation anesthetic in neonates and children. Neonatal sevoflurane exposure causes widespread neurodegeneration and cognitive impairments. Development of compounds that could effectively prevent/reduce the adverse effects is of tremendous medical value. |
| first_indexed | 2024-12-21T02:44:50Z |
| format | Article |
| id | doaj.art-409e59a9006c40fc9c3c5a42f3bd61f5 |
| institution | Directory Open Access Journal |
| issn | 2081-6936 |
| language | English |
| last_indexed | 2024-12-21T02:44:50Z |
| publishDate | 2018-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Translational Neuroscience |
| spelling | doaj.art-409e59a9006c40fc9c3c5a42f3bd61f52022-12-21T19:18:36ZengDe GruyterTranslational Neuroscience2081-69362018-07-0191889810.1515/tnsci-2018-0015tnsci-2018-0015Baicalein inhibits neuroapoptosis via pathways in sevoflurane induced ratsWang Si0Zhou Yu1Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, 637000Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, 637000Baicalein, a bioactive flavonoid was explored for its capability to attenuate sevoflurane induced neuronal apoptosis and to improve behavioural and cognitive impairments. Sevoflurane is a frequently used inhalation anesthetic in neonates and children. Neonatal sevoflurane exposure causes widespread neurodegeneration and cognitive impairments. Development of compounds that could effectively prevent/reduce the adverse effects is of tremendous medical value.https://doi.org/10.1515/tnsci-2018-0015baicaleinjnk/erk signalling pathwayneuroapoptosispi3k/akt/gsk-3β signallingsevoflurane |
| spellingShingle | Wang Si Zhou Yu Baicalein inhibits neuroapoptosis via pathways in sevoflurane induced rats Translational Neuroscience baicalein jnk/erk signalling pathway neuroapoptosis pi3k/akt/gsk-3β signalling sevoflurane |
| title | Baicalein inhibits neuroapoptosis via pathways in sevoflurane induced rats |
| title_full | Baicalein inhibits neuroapoptosis via pathways in sevoflurane induced rats |
| title_fullStr | Baicalein inhibits neuroapoptosis via pathways in sevoflurane induced rats |
| title_full_unstemmed | Baicalein inhibits neuroapoptosis via pathways in sevoflurane induced rats |
| title_short | Baicalein inhibits neuroapoptosis via pathways in sevoflurane induced rats |
| title_sort | baicalein inhibits neuroapoptosis via pathways in sevoflurane induced rats |
| topic | baicalein jnk/erk signalling pathway neuroapoptosis pi3k/akt/gsk-3β signalling sevoflurane |
| url | https://doi.org/10.1515/tnsci-2018-0015 |
| work_keys_str_mv | AT wangsi baicaleininhibitsneuroapoptosisviapathwaysinsevofluraneinducedrats AT zhouyu baicaleininhibitsneuroapoptosisviapathwaysinsevofluraneinducedrats |