Prognostic value of lymphocyte count for in-hospital mortality in patients with severe AECOPD
Abstract Background Patients with severe acute exacerbations of chronic obstructive pulmonary disease often have a poor prognosis. Biomarkers can help clinicians personalize the assessment of different patients and mitigate mortality. The present study sought to determine if the lymphocyte count cou...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-022-02137-1 |
| _version_ | 1828339557341331456 |
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| author | Yanlu Hu Huanyu Long Yang Cao Yanfei Guo |
| author_facet | Yanlu Hu Huanyu Long Yang Cao Yanfei Guo |
| author_sort | Yanlu Hu |
| collection | DOAJ |
| description | Abstract Background Patients with severe acute exacerbations of chronic obstructive pulmonary disease often have a poor prognosis. Biomarkers can help clinicians personalize the assessment of different patients and mitigate mortality. The present study sought to determine if the lymphocyte count could act as a risk factor for mortality in individuals with severe AECOPD. Methods A retrospective study was carried out with 458 cases who had severe AECOPD. For analysis, patients were divided into two groups on the basis of lymphocyte count: < 0.8 × 109/L and ≥ 0.8 × 109/L. Results Patients who fulfilled the criteria for inclusion were enrolled, namely 458 with a mean age of 78.2 ± 8.2 years. Of these patients, 175 had a low lymphocyte count. Compared to patients with normal lymphocyte counts, those with low counts were older (79.2 ± 7.4 vs. 77.5 ± 8.6 years, p = 0.036), had lower activities of daily living scores on admission (35.9 ± 27.6 vs. 47.5 ± 17.1, p < 0.001), and had a greater need for home oxygen therapy (84.6 vs. 72.1%, p = 0.002). Patients with low lymphocytes had higher mortality rates during hospitalization (17.1 vs. 7.1%, p = 0.001), longer hospital stay (median [IQR] 16 days [12–26] vs. 14 days [10–20], p = 0.002) and longer time on mechanical ventilation (median [IQR] 11.6 days [5.8–18.7] vs. 10.9 days [3.8–11.6], p < 0.001). The logistic regression analysis showed lymphocyte count < 0.8 × 109/L was an independent risk factor associated with in-hospital mortality (OR 2.74, 95%CI 1.33–5.66, p = 0.006). Conclusion Lymphocyte count could act as a predictor of mortality in patients with severe AECOPD. |
| first_indexed | 2024-04-13T22:44:32Z |
| format | Article |
| id | doaj.art-40a012a5e4324c038ba47e66fd3e80d2 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-13T22:44:32Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-40a012a5e4324c038ba47e66fd3e80d22022-12-22T02:26:28ZengBMCBMC Pulmonary Medicine1471-24662022-10-012211710.1186/s12890-022-02137-1Prognostic value of lymphocyte count for in-hospital mortality in patients with severe AECOPDYanlu Hu0Huanyu Long1Yang Cao2Yanfei Guo3Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical SciencesDepartment of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical SciencesThe First Affiliated Hospital of Jinan University (Also Known as Guangzhou Overseas Chinese Hospital and the First Clinical Medical College of Jinan University)Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical SciencesAbstract Background Patients with severe acute exacerbations of chronic obstructive pulmonary disease often have a poor prognosis. Biomarkers can help clinicians personalize the assessment of different patients and mitigate mortality. The present study sought to determine if the lymphocyte count could act as a risk factor for mortality in individuals with severe AECOPD. Methods A retrospective study was carried out with 458 cases who had severe AECOPD. For analysis, patients were divided into two groups on the basis of lymphocyte count: < 0.8 × 109/L and ≥ 0.8 × 109/L. Results Patients who fulfilled the criteria for inclusion were enrolled, namely 458 with a mean age of 78.2 ± 8.2 years. Of these patients, 175 had a low lymphocyte count. Compared to patients with normal lymphocyte counts, those with low counts were older (79.2 ± 7.4 vs. 77.5 ± 8.6 years, p = 0.036), had lower activities of daily living scores on admission (35.9 ± 27.6 vs. 47.5 ± 17.1, p < 0.001), and had a greater need for home oxygen therapy (84.6 vs. 72.1%, p = 0.002). Patients with low lymphocytes had higher mortality rates during hospitalization (17.1 vs. 7.1%, p = 0.001), longer hospital stay (median [IQR] 16 days [12–26] vs. 14 days [10–20], p = 0.002) and longer time on mechanical ventilation (median [IQR] 11.6 days [5.8–18.7] vs. 10.9 days [3.8–11.6], p < 0.001). The logistic regression analysis showed lymphocyte count < 0.8 × 109/L was an independent risk factor associated with in-hospital mortality (OR 2.74, 95%CI 1.33–5.66, p = 0.006). Conclusion Lymphocyte count could act as a predictor of mortality in patients with severe AECOPD.https://doi.org/10.1186/s12890-022-02137-1ExacerbationChronic obstructive pulmonary diseaseLymphocyte countMortalityBiomarker |
| spellingShingle | Yanlu Hu Huanyu Long Yang Cao Yanfei Guo Prognostic value of lymphocyte count for in-hospital mortality in patients with severe AECOPD BMC Pulmonary Medicine Exacerbation Chronic obstructive pulmonary disease Lymphocyte count Mortality Biomarker |
| title | Prognostic value of lymphocyte count for in-hospital mortality in patients with severe AECOPD |
| title_full | Prognostic value of lymphocyte count for in-hospital mortality in patients with severe AECOPD |
| title_fullStr | Prognostic value of lymphocyte count for in-hospital mortality in patients with severe AECOPD |
| title_full_unstemmed | Prognostic value of lymphocyte count for in-hospital mortality in patients with severe AECOPD |
| title_short | Prognostic value of lymphocyte count for in-hospital mortality in patients with severe AECOPD |
| title_sort | prognostic value of lymphocyte count for in hospital mortality in patients with severe aecopd |
| topic | Exacerbation Chronic obstructive pulmonary disease Lymphocyte count Mortality Biomarker |
| url | https://doi.org/10.1186/s12890-022-02137-1 |
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