The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib

The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib

Abstract Low‐flow vascular malformations are congenital overgrowths composed of abnormal blood vessels potentially causing pain, bleeding and obstruction of different organs. These diseases are caused by oncogenic mutations in the endothelium, which result in overactivation of the PI3K/AKT pathway....

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Main Authors: Piotr Kobialka, Helena Sabata, Odena Vilalta, Leonor Gouveia, Ana Angulo‐Urarte, Laia Muixí, Jasmina Zanoncello, Oscar Muñoz‐Aznar, Nagore G Olaciregui, Lucia Fanlo, Anna Esteve‐Codina, Cinzia Lavarino, Biola M Javierre, Veronica Celis, Carlota Rovira, Susana López‐Fernández, Eulàlia Baselga, Jaume Mora, Sandra D Castillo, Mariona Graupera
Format: Article
Language:English
Published: Springer Nature 2022-06-01
Series:EMBO Molecular Medicine
Subjects:
AKT
angiogenesis
endothelial cell
PI3K
vascular malformations
Online Access:https://doi.org/10.15252/emmm.202115619

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