| Summary: | Synthesis of the natural product prattinin A and some new derivatives has been achieved using abietic acid. The final products and a selection of intermediates were evaluated for their antibacterial activity against three human pathogenic bacteria: <i>E. coli</i>, <i>P. aeruginosa</i>, and <i>S. aureus</i>. The results showed that the antibacterial activity varies depending on the chemical structure of the compounds. Notably, compound <b>27</b> exhibited the most potent activity against <i>E. coli</i> and <i>P. aeruginosa,</i> with a minimal inhibitory concentration (MIC) of 11.7 µg/mL, comparable to that of the standard antibiotic ciprofloxacin, and strong activity against <i>S. aureus</i>, with an MIC of 23.4 µg/mL. Furthermore, we assessed the stability of these derivative compounds as potential antimicrobial agents and determined their interactions with the crystal structure of the protein receptor mutant TEM-12 from <i>E. coli</i> (pdb:1ESU) using molecular docking via UCSF Chimera software 1.17.3. The results suggest that <b>27</b> has potential as a natural antibiotic agent.
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