Randomised Control Study of Palonosetron Versus Dexamethasone in Preventing Postoperative Nausea and Vomiting Following Ear and Nose Surgeries under General Anesthesia
Introduction: Postoperative Nausea and Vomiting (PONV) is defined as any nausea or vomiting that occurs during the first 48 hours after surgery. It is considered as a distressing event following anaesthesia. The incidences of PONV is 25-30% in all post-surgical patients and the incidence of PONV...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2018-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/12265/35379_CE[Ra1]_F(SHU)_PF1(AGAK)_PFA(AK)_PB(AG_RK)_PN(P).pdf |
| Summary: | Introduction: Postoperative Nausea and Vomiting (PONV) is
defined as any nausea or vomiting that occurs during the first
48 hours after surgery. It is considered as a distressing event
following anaesthesia. The incidences of PONV is 25-30%
in all post-surgical patients and the incidence of PONV with
middle ear surgeries are 50%-80%. Various pharmacological
techniques were used to prevent PONV. Five-HT3 receptor
antagonists are most commonly used prophylactic agents.
Aim: To compare the efficacy and safety of intravenous
Palonosetron 75 mcg, and intravenous Dexamethasone 8 mg
in preventing PONV.
Materials and Methods: Hundred patients of 18-60 years
undergoing ear and nose surgeries under general anaesthesia
requiring intubation for more than one hour were randomised
into two groups of 50 patients each. Group P received 75mcg
of palonosetron and Group D received 8 mg of dexamethasone
before induction. The incidence of PONV in the two groups was
noted using a four point score until 24 hours postoperatively.
Results: The overall incidence of PONV in 0-24 hours were
maximum in the dexamethasone group with 50% and 20%
in palonosetron group. The four point score was higher in
dexamethasone group compared to palonosetron group & with
statistically significant difference. The requirement of rescue
antiemetic medication was 30% in dexamethasone group and
10% in palonosetron group.
Conclusion: Our study has shown that palonosetron is more
effective in the prevention of PONV without apparent side effects. |
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| ISSN: | 2249-782X 0973-709X |