Photodynamic Therapy: Targeting Cancer Biomarkers for the Treatment of Cancers
Photodynamic therapy (PDT) is a well-documented therapy that has emerged as an effective treatment modality of cancers. PDT utilizes harmless light to activate non- or minimally toxic photosensitizers to generate cytotoxic species for malignant cell eradication. Compared with conventional chemothera...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/12/2992 |
| _version_ | 1797530040963956736 |
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| author | Xinning Wang Dong Luo James P. Basilion |
| author_facet | Xinning Wang Dong Luo James P. Basilion |
| author_sort | Xinning Wang |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) is a well-documented therapy that has emerged as an effective treatment modality of cancers. PDT utilizes harmless light to activate non- or minimally toxic photosensitizers to generate cytotoxic species for malignant cell eradication. Compared with conventional chemotherapy and radiotherapy, PDT is appealing by virtue of the minimal invasiveness, its safety, as well as its selectivity, and the fact that it can induce an immune response. Although local illumination of the cancer lesions renders intrinsic selectivity of PDT, most photosensitizers used in PDT do not display significant tumor tissue selectivity. There is a need for targeted delivery of photosensitizers. The molecular identification of cancer antigens has opened new possibilities for the development of effective targeted therapy for cancer patients. This review provides a brief overview of recent achievements of targeted delivery of photosensitizers to cancer cells by targeting well-established cancer biomarkers. Overall, targeted PDT offers enhanced intracellular accumulation of the photosensitizer, leading to improved PDT efficacy and reduced toxicity to normal tissues. |
| first_indexed | 2024-03-10T10:23:17Z |
| format | Article |
| id | doaj.art-40a615a7806a4e48ab9b5fc1ea524f8e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T10:23:17Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-40a615a7806a4e48ab9b5fc1ea524f8e2023-11-22T00:11:48ZengMDPI AGCancers2072-66942021-06-011312299210.3390/cancers13122992Photodynamic Therapy: Targeting Cancer Biomarkers for the Treatment of CancersXinning Wang0Dong Luo1James P. Basilion2Department of Biomedical Engineering, Case Western Reserve University, 11100 Euclid Ave, Wearn Building B-49, Cleveland, OH 44106, USADepartment of Radiology, Case Western Reserve University, 11100 Euclid Ave, Wearn Building B-44, Cleveland, OH 44106, USADepartment of Biomedical Engineering, Case Western Reserve University, 11100 Euclid Ave, Wearn Building B-49, Cleveland, OH 44106, USAPhotodynamic therapy (PDT) is a well-documented therapy that has emerged as an effective treatment modality of cancers. PDT utilizes harmless light to activate non- or minimally toxic photosensitizers to generate cytotoxic species for malignant cell eradication. Compared with conventional chemotherapy and radiotherapy, PDT is appealing by virtue of the minimal invasiveness, its safety, as well as its selectivity, and the fact that it can induce an immune response. Although local illumination of the cancer lesions renders intrinsic selectivity of PDT, most photosensitizers used in PDT do not display significant tumor tissue selectivity. There is a need for targeted delivery of photosensitizers. The molecular identification of cancer antigens has opened new possibilities for the development of effective targeted therapy for cancer patients. This review provides a brief overview of recent achievements of targeted delivery of photosensitizers to cancer cells by targeting well-established cancer biomarkers. Overall, targeted PDT offers enhanced intracellular accumulation of the photosensitizer, leading to improved PDT efficacy and reduced toxicity to normal tissues.https://www.mdpi.com/2072-6694/13/12/2992photodynamic therapyphotosensitizertargeted therapyantibodiesligands |
| spellingShingle | Xinning Wang Dong Luo James P. Basilion Photodynamic Therapy: Targeting Cancer Biomarkers for the Treatment of Cancers Cancers photodynamic therapy photosensitizer targeted therapy antibodies ligands |
| title | Photodynamic Therapy: Targeting Cancer Biomarkers for the Treatment of Cancers |
| title_full | Photodynamic Therapy: Targeting Cancer Biomarkers for the Treatment of Cancers |
| title_fullStr | Photodynamic Therapy: Targeting Cancer Biomarkers for the Treatment of Cancers |
| title_full_unstemmed | Photodynamic Therapy: Targeting Cancer Biomarkers for the Treatment of Cancers |
| title_short | Photodynamic Therapy: Targeting Cancer Biomarkers for the Treatment of Cancers |
| title_sort | photodynamic therapy targeting cancer biomarkers for the treatment of cancers |
| topic | photodynamic therapy photosensitizer targeted therapy antibodies ligands |
| url | https://www.mdpi.com/2072-6694/13/12/2992 |
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