Comparison of High and Low Affinity Serotonin 1A Receptors by PET In Vivo in Nonhuman Primates

Comparison of High and Low Affinity Serotonin 1A Receptors by PET In Vivo in Nonhuman Primates

Serotonin (5-HT) 1A receptors exist in high and low affinity states. Agonist ligands bind preferentially to the high affinity state receptors, providing a more functionally relevant measure than antagonist binding. We now report comparison of 5-HT1A binding in vivo using both [11C]CUMI-101 (agonist)...

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Bibliographic Details
Main Authors:	J.S. Dileep Kumar, Matthew S. Milak, Vattoly J. Majo, Jaya Prabhakaran, Pratap Mali, Lyudmila Savenkova, J. John Mann, Ramin V. Parsey
Format:	Article
Language:	English
Published:	Elsevier 2012-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319304402

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