Gastrointestinal disease is an important influencing factor of osteoporosis fracture:a retrospective study in chinese postmenopausal women
Abstract Backgroud The influencing factors of osteoporosis are complex, the incidence of osteoporosis is higher in middle-aged and elderly women, and osteoporotic fractures (OF) can seriously affect quality of life. Currently, the correlation analysis between gastrointestinal diseases and OF focuses...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-08-01
|
| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-023-06765-4 |
| _version_ | 1797454142081335296 |
|---|---|
| author | PengChao Xu JiRong Ge Hong Jiang YuJuan Lin YunJin Ye XiaoBin Huang YanYan He LiPeng Xue |
| author_facet | PengChao Xu JiRong Ge Hong Jiang YuJuan Lin YunJin Ye XiaoBin Huang YanYan He LiPeng Xue |
| author_sort | PengChao Xu |
| collection | DOAJ |
| description | Abstract Backgroud The influencing factors of osteoporosis are complex, the incidence of osteoporosis is higher in middle-aged and elderly women, and osteoporotic fractures (OF) can seriously affect quality of life. Currently, the correlation analysis between gastrointestinal diseases and OF focuses more on diseases such as gastric cancer and inflammatory bowel disease (IBD). This study analyzed the risk factors for osteoporosis and osteoporotic fractures in 1567 postmenopausal women in Fuzhou, China. The purpose is to explore the potential influence of gastrointestinal diseases on the occurrence of OF. Methods According to inclusion and exclusion criteria, a total of 1567 subjects were included in the analysis of OP risk factors, including 647 in the OP group and 920 in the NOP group. A total of 616 subjects were included in the analysis of correlation between OF and gastrointestinal diseases, including 132 in OF group and 484 in NF group. Statistical analysis shows that age (OR = 1.062, 95% CI = 1.045–1.080), height (OR = 0.089, 95% CI = 0.009–0.857), weight (OR = 0.981,95% CI = 0.967–0.995) and nature of work (P = 0.010) are the main risk factors for osteoporosis in postmenopausal women in southeast China, and gastrointestinal diseases (OR = 1.583, 95% CI = 1.070–2.343) and height (OR = 0.003, 95% CI = 0.000-0.104) are the main risk factors of OF. Conclusions The main factors affecting the occurrence of OP in postmenopausal women in southeast China are individual characteristic. Gastrointestinal diseases that do not directly affect BMD increase the risk of OF in osteoporotic patients. |
| first_indexed | 2024-03-09T15:33:00Z |
| format | Article |
| id | doaj.art-40a98b9c1f5d483b9d26ebb906eba22a |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-03-09T15:33:00Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-40a98b9c1f5d483b9d26ebb906eba22a2023-11-26T12:08:05ZengBMCBMC Musculoskeletal Disorders1471-24742023-08-0124111210.1186/s12891-023-06765-4Gastrointestinal disease is an important influencing factor of osteoporosis fracture:a retrospective study in chinese postmenopausal womenPengChao Xu0JiRong Ge1Hong Jiang2YuJuan Lin3YunJin Ye4XiaoBin Huang5YanYan He6LiPeng Xue7Fujian University of Traditional Chinese MedicineFujian Key Laboratory of Integrated Traditional Chinese and Western Medicine for the Prevention and Treatment of Osteoporosis(Fujian Academy of Chinese Medical Sciences, The Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine), Fujian Academy of Chinese Medical SciencesFujian University of Traditional Chinese MedicineFujian University of Traditional Chinese MedicineFujian Key Laboratory of Integrated Traditional Chinese and Western Medicine for the Prevention and Treatment of Osteoporosis(Fujian Academy of Chinese Medical Sciences, The Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine), Fujian Academy of Chinese Medical SciencesFujian Key Laboratory of Integrated Traditional Chinese and Western Medicine for the Prevention and Treatment of Osteoporosis(Fujian Academy of Chinese Medical Sciences, The Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine), Fujian Academy of Chinese Medical SciencesFujian Key Laboratory of Integrated Traditional Chinese and Western Medicine for the Prevention and Treatment of Osteoporosis(Fujian Academy of Chinese Medical Sciences, The Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine), Fujian Academy of Chinese Medical SciencesFujian Key Laboratory of Integrated Traditional Chinese and Western Medicine for the Prevention and Treatment of Osteoporosis(Fujian Academy of Chinese Medical Sciences, The Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine), Fujian Academy of Chinese Medical SciencesAbstract Backgroud The influencing factors of osteoporosis are complex, the incidence of osteoporosis is higher in middle-aged and elderly women, and osteoporotic fractures (OF) can seriously affect quality of life. Currently, the correlation analysis between gastrointestinal diseases and OF focuses more on diseases such as gastric cancer and inflammatory bowel disease (IBD). This study analyzed the risk factors for osteoporosis and osteoporotic fractures in 1567 postmenopausal women in Fuzhou, China. The purpose is to explore the potential influence of gastrointestinal diseases on the occurrence of OF. Methods According to inclusion and exclusion criteria, a total of 1567 subjects were included in the analysis of OP risk factors, including 647 in the OP group and 920 in the NOP group. A total of 616 subjects were included in the analysis of correlation between OF and gastrointestinal diseases, including 132 in OF group and 484 in NF group. Statistical analysis shows that age (OR = 1.062, 95% CI = 1.045–1.080), height (OR = 0.089, 95% CI = 0.009–0.857), weight (OR = 0.981,95% CI = 0.967–0.995) and nature of work (P = 0.010) are the main risk factors for osteoporosis in postmenopausal women in southeast China, and gastrointestinal diseases (OR = 1.583, 95% CI = 1.070–2.343) and height (OR = 0.003, 95% CI = 0.000-0.104) are the main risk factors of OF. Conclusions The main factors affecting the occurrence of OP in postmenopausal women in southeast China are individual characteristic. Gastrointestinal diseases that do not directly affect BMD increase the risk of OF in osteoporotic patients.https://doi.org/10.1186/s12891-023-06765-4OsteoporosisOsteoporotic fractureGastrointestinal diseasesCase control studyChinese postmenopausal women |
| spellingShingle | PengChao Xu JiRong Ge Hong Jiang YuJuan Lin YunJin Ye XiaoBin Huang YanYan He LiPeng Xue Gastrointestinal disease is an important influencing factor of osteoporosis fracture:a retrospective study in chinese postmenopausal women BMC Musculoskeletal Disorders Osteoporosis Osteoporotic fracture Gastrointestinal diseases Case control study Chinese postmenopausal women |
| title | Gastrointestinal disease is an important influencing factor of osteoporosis fracture:a retrospective study in chinese postmenopausal women |
| title_full | Gastrointestinal disease is an important influencing factor of osteoporosis fracture:a retrospective study in chinese postmenopausal women |
| title_fullStr | Gastrointestinal disease is an important influencing factor of osteoporosis fracture:a retrospective study in chinese postmenopausal women |
| title_full_unstemmed | Gastrointestinal disease is an important influencing factor of osteoporosis fracture:a retrospective study in chinese postmenopausal women |
| title_short | Gastrointestinal disease is an important influencing factor of osteoporosis fracture:a retrospective study in chinese postmenopausal women |
| title_sort | gastrointestinal disease is an important influencing factor of osteoporosis fracture a retrospective study in chinese postmenopausal women |
| topic | Osteoporosis Osteoporotic fracture Gastrointestinal diseases Case control study Chinese postmenopausal women |
| url | https://doi.org/10.1186/s12891-023-06765-4 |
| work_keys_str_mv | AT pengchaoxu gastrointestinaldiseaseisanimportantinfluencingfactorofosteoporosisfracturearetrospectivestudyinchinesepostmenopausalwomen AT jirongge gastrointestinaldiseaseisanimportantinfluencingfactorofosteoporosisfracturearetrospectivestudyinchinesepostmenopausalwomen AT hongjiang gastrointestinaldiseaseisanimportantinfluencingfactorofosteoporosisfracturearetrospectivestudyinchinesepostmenopausalwomen AT yujuanlin gastrointestinaldiseaseisanimportantinfluencingfactorofosteoporosisfracturearetrospectivestudyinchinesepostmenopausalwomen AT yunjinye gastrointestinaldiseaseisanimportantinfluencingfactorofosteoporosisfracturearetrospectivestudyinchinesepostmenopausalwomen AT xiaobinhuang gastrointestinaldiseaseisanimportantinfluencingfactorofosteoporosisfracturearetrospectivestudyinchinesepostmenopausalwomen AT yanyanhe gastrointestinaldiseaseisanimportantinfluencingfactorofosteoporosisfracturearetrospectivestudyinchinesepostmenopausalwomen AT lipengxue gastrointestinaldiseaseisanimportantinfluencingfactorofosteoporosisfracturearetrospectivestudyinchinesepostmenopausalwomen |