Review: Quality of Life in Children with Non-cystic Fibrosis Bronchiectasis
Non-cystic fibrosis bronchiectasis (NCFB) has gained renewed interest, due to its increasing health-care burden. Annual mortality statistics in England and Wales showed that under 1,000 people die from bronchiectasis each year, and this number is increasing by 3% yearly. Unfortunately, there is a se...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-04-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fped.2017.00084/full |
| _version_ | 1828356850913902592 |
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| author | Anna Marie Nathan Anna Marie Nathan Jessie Anne de Bruyne Jessie Anne de Bruyne Kah Peng Eg Kah Peng Eg Surendran Thavagnanam Surendran Thavagnanam |
| author_facet | Anna Marie Nathan Anna Marie Nathan Jessie Anne de Bruyne Jessie Anne de Bruyne Kah Peng Eg Kah Peng Eg Surendran Thavagnanam Surendran Thavagnanam |
| author_sort | Anna Marie Nathan |
| collection | DOAJ |
| description | Non-cystic fibrosis bronchiectasis (NCFB) has gained renewed interest, due to its increasing health-care burden. Annual mortality statistics in England and Wales showed that under 1,000 people die from bronchiectasis each year, and this number is increasing by 3% yearly. Unfortunately, there is a severe lack of well-powered, randomized controlled trials to guide clinicians how to manage NCFB effectively. Quality-of-life (QOL) measures in NCFB are an important aspect of clinical care that has not been studied well. Commonly used disease-specific questionnaires in children with NCFB are the St George’s Respiratory Questionnaire, Short Form-36, the Leicester Cough Questionnaire, and the Parent Cough-Specific Quality of Life questionnaire (PC-QOL). Of these, only the PC-QOL can be used in young children, as it is a parent-proxy questionnaire. We reviewed pediatric studies looking at QOL in children with NCFB and cystic fibrosis. All types of airway clearance techniques appear to be safe and have no significant benefit over each other. Number of exacerbations and hospitalizations correlated with QOL scores, while symptom subscales correlated with lung function, worse QOL, frequent antibiotic requirements, and duration of regular follow-up in only one study. There was a correlation between QOL and age of diagnosis in children with primary ciliary dyskinesia. Other studies have shown no relationship between QOL scores and etiology of NCFB as well as CT changes. As for treatments, oral azithromycin and yoga have demonstrated some improvement in QOL scores. In conclusion, more studies are required to accurately determine important factors contributing to QOL. |
| first_indexed | 2024-04-14T03:05:52Z |
| format | Article |
| id | doaj.art-40a9a10f04a547c5a83164daf8503fc6 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-14T03:05:52Z |
| publishDate | 2017-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-40a9a10f04a547c5a83164daf8503fc62022-12-22T02:15:44ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602017-04-01510.3389/fped.2017.00084248127Review: Quality of Life in Children with Non-cystic Fibrosis BronchiectasisAnna Marie Nathan0Anna Marie Nathan1Jessie Anne de Bruyne2Jessie Anne de Bruyne3Kah Peng Eg4Kah Peng Eg5Surendran Thavagnanam6Surendran Thavagnanam7Department of Pediatrics, University of Malaya, Kuala Lumpur, MalaysiaUniversity Malaya Pediatric and Child Health Research Group, University of Malaya, Kuala Lumpur, MalaysiaDepartment of Pediatrics, University of Malaya, Kuala Lumpur, MalaysiaUniversity Malaya Pediatric and Child Health Research Group, University of Malaya, Kuala Lumpur, MalaysiaDepartment of Pediatrics, University of Malaya, Kuala Lumpur, MalaysiaUniversity Malaya Pediatric and Child Health Research Group, University of Malaya, Kuala Lumpur, MalaysiaDepartment of Pediatrics, University of Malaya, Kuala Lumpur, MalaysiaUniversity Malaya Pediatric and Child Health Research Group, University of Malaya, Kuala Lumpur, MalaysiaNon-cystic fibrosis bronchiectasis (NCFB) has gained renewed interest, due to its increasing health-care burden. Annual mortality statistics in England and Wales showed that under 1,000 people die from bronchiectasis each year, and this number is increasing by 3% yearly. Unfortunately, there is a severe lack of well-powered, randomized controlled trials to guide clinicians how to manage NCFB effectively. Quality-of-life (QOL) measures in NCFB are an important aspect of clinical care that has not been studied well. Commonly used disease-specific questionnaires in children with NCFB are the St George’s Respiratory Questionnaire, Short Form-36, the Leicester Cough Questionnaire, and the Parent Cough-Specific Quality of Life questionnaire (PC-QOL). Of these, only the PC-QOL can be used in young children, as it is a parent-proxy questionnaire. We reviewed pediatric studies looking at QOL in children with NCFB and cystic fibrosis. All types of airway clearance techniques appear to be safe and have no significant benefit over each other. Number of exacerbations and hospitalizations correlated with QOL scores, while symptom subscales correlated with lung function, worse QOL, frequent antibiotic requirements, and duration of regular follow-up in only one study. There was a correlation between QOL and age of diagnosis in children with primary ciliary dyskinesia. Other studies have shown no relationship between QOL scores and etiology of NCFB as well as CT changes. As for treatments, oral azithromycin and yoga have demonstrated some improvement in QOL scores. In conclusion, more studies are required to accurately determine important factors contributing to QOL.http://journal.frontiersin.org/article/10.3389/fped.2017.00084/fullquality of lifechildbronchiectasiscoughreviewtreatment |
| spellingShingle | Anna Marie Nathan Anna Marie Nathan Jessie Anne de Bruyne Jessie Anne de Bruyne Kah Peng Eg Kah Peng Eg Surendran Thavagnanam Surendran Thavagnanam Review: Quality of Life in Children with Non-cystic Fibrosis Bronchiectasis Frontiers in Pediatrics quality of life child bronchiectasis cough review treatment |
| title | Review: Quality of Life in Children with Non-cystic Fibrosis Bronchiectasis |
| title_full | Review: Quality of Life in Children with Non-cystic Fibrosis Bronchiectasis |
| title_fullStr | Review: Quality of Life in Children with Non-cystic Fibrosis Bronchiectasis |
| title_full_unstemmed | Review: Quality of Life in Children with Non-cystic Fibrosis Bronchiectasis |
| title_short | Review: Quality of Life in Children with Non-cystic Fibrosis Bronchiectasis |
| title_sort | review quality of life in children with non cystic fibrosis bronchiectasis |
| topic | quality of life child bronchiectasis cough review treatment |
| url | http://journal.frontiersin.org/article/10.3389/fped.2017.00084/full |
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