Epidemiological and microbiological analysis of ventilator-associated pneumonia patients in a public teaching hospital
Ventilator-associated pneumonia (VAP) is the most commonly-acquired infection in patients in intensive care units. We analyzed epidemiological and microbiological characteristics and the outcome, in a cohort of critically-ill patients with confirmed diagnosis of VAP. All patients who had been on mec...
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500009&lng=en&tlng=en |
| _version_ | 1818413441320222720 |
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| author | João Manoel da Silva Júnior Ederlon Rezende Thaís Guimarães Edvaldo V. dos Campos Luiz André Magno Lívia Consorti Renata Andréa Pietro Pereira Maria de Lourdes Nascimento João Silva de Mendonça |
| author_facet | João Manoel da Silva Júnior Ederlon Rezende Thaís Guimarães Edvaldo V. dos Campos Luiz André Magno Lívia Consorti Renata Andréa Pietro Pereira Maria de Lourdes Nascimento João Silva de Mendonça |
| author_sort | João Manoel da Silva Júnior |
| collection | DOAJ |
| description | Ventilator-associated pneumonia (VAP) is the most commonly-acquired infection in patients in intensive care units. We analyzed epidemiological and microbiological characteristics and the outcome, in a cohort of critically-ill patients with confirmed diagnosis of VAP. All patients who had been on mechanical ventilation (MV) for more than 48 hours were included in our study; material collection for microbiological analysis was done within the first 24 hours after beginning treatment or after changing antibiotics. There were 55/265 (20.7%) VAP cases diagnosed, at a rate of 21.6 episodes per 1,000 days of mechanical ventilation. Mean age of the patients was 66 years, with a mean APACHE II score of 26.7 + 7.0; male patients were more prevalent. The mortality rates in the intensive care unit (ICU) and during the hospital stay were 71% and 80%, respectively. MV duration in patients with VAP was 17 (range 3-43) days and among patients who had not developed VAP, 6 (2-32) days (p < 0.0001). 98.2% of the samples were positive, with a high prevalence of Gram-negative bacteria, mainly Acinetobacter calcoaceticus. Risk factors for death included age, MV duration and surgery. VAP incidence in this sample of critically-ill patients was high, with a high mortality rate. Control and prevention strategies based on continuing education of healthcare workers, developed by a multidisciplinary team, should be encouraged to minimize morbimortality of this infection. |
| first_indexed | 2024-12-14T11:03:15Z |
| format | Article |
| id | doaj.art-40ab5c11206b48939895576e1777203e |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-14T11:03:15Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-40ab5c11206b48939895576e1777203e2022-12-21T23:04:38ZengElsevierBrazilian Journal of Infectious Diseases1678-439111548248810.1590/S1413-86702007000500009S1413-86702007000500009Epidemiological and microbiological analysis of ventilator-associated pneumonia patients in a public teaching hospitalJoão Manoel da Silva Júnior0Ederlon Rezende1Thaís Guimarães2Edvaldo V. dos CamposLuiz André Magno3Lívia Consorti4Renata Andréa Pietro Pereira5Maria de Lourdes Nascimento6João Silva de Mendonça7Hospital do Servidor Público Estadual Francisco Morato de OliveiraHospital do Servidor Público Estadual Francisco Morato de OliveiraHospital do Servidor Público Estadual Francisco Morato de OliveiraHospital do Servidor Público Estadual Francisco Morato de OliveiraHospital do Servidor Público Estadual Francisco Morato de OliveiraHospital do Servidor Público Estadual Francisco Morato de OliveiraHospital do Servidor Público Estadual Francisco Morato de OliveiraHospital do Servidor Público Estadual Francisco Morato de OliveiraVentilator-associated pneumonia (VAP) is the most commonly-acquired infection in patients in intensive care units. We analyzed epidemiological and microbiological characteristics and the outcome, in a cohort of critically-ill patients with confirmed diagnosis of VAP. All patients who had been on mechanical ventilation (MV) for more than 48 hours were included in our study; material collection for microbiological analysis was done within the first 24 hours after beginning treatment or after changing antibiotics. There were 55/265 (20.7%) VAP cases diagnosed, at a rate of 21.6 episodes per 1,000 days of mechanical ventilation. Mean age of the patients was 66 years, with a mean APACHE II score of 26.7 + 7.0; male patients were more prevalent. The mortality rates in the intensive care unit (ICU) and during the hospital stay were 71% and 80%, respectively. MV duration in patients with VAP was 17 (range 3-43) days and among patients who had not developed VAP, 6 (2-32) days (p < 0.0001). 98.2% of the samples were positive, with a high prevalence of Gram-negative bacteria, mainly Acinetobacter calcoaceticus. Risk factors for death included age, MV duration and surgery. VAP incidence in this sample of critically-ill patients was high, with a high mortality rate. Control and prevention strategies based on continuing education of healthcare workers, developed by a multidisciplinary team, should be encouraged to minimize morbimortality of this infection.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500009&lng=en&tlng=enVentilator-associated pneumoniaepidemiologymicrobiology |
| spellingShingle | João Manoel da Silva Júnior Ederlon Rezende Thaís Guimarães Edvaldo V. dos Campos Luiz André Magno Lívia Consorti Renata Andréa Pietro Pereira Maria de Lourdes Nascimento João Silva de Mendonça Epidemiological and microbiological analysis of ventilator-associated pneumonia patients in a public teaching hospital Brazilian Journal of Infectious Diseases Ventilator-associated pneumonia epidemiology microbiology |
| title | Epidemiological and microbiological analysis of ventilator-associated pneumonia patients in a public teaching hospital |
| title_full | Epidemiological and microbiological analysis of ventilator-associated pneumonia patients in a public teaching hospital |
| title_fullStr | Epidemiological and microbiological analysis of ventilator-associated pneumonia patients in a public teaching hospital |
| title_full_unstemmed | Epidemiological and microbiological analysis of ventilator-associated pneumonia patients in a public teaching hospital |
| title_short | Epidemiological and microbiological analysis of ventilator-associated pneumonia patients in a public teaching hospital |
| title_sort | epidemiological and microbiological analysis of ventilator associated pneumonia patients in a public teaching hospital |
| topic | Ventilator-associated pneumonia epidemiology microbiology |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500009&lng=en&tlng=en |
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