Review of machine perfusion studies in vascularized composite allotransplant preservation
The applications of Vascularized composite allotransplantation (VCA) are increasing since the first successful hand transplantation in 1998. However, the abundance of muscle tissue makes VCA's vulnerable to ischemia-reperfusion injury (IRI), which has detrimental effects on the outcome of the p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Transplantation |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/frtra.2023.1323387/full |
| _version_ | 1797384879402385408 |
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| author | Çağdaş Duru Felor Biniazan Nina Hadzimustafic Nina Hadzimustafic Andrew D'Elia Andrew D'Elia Valentina Shamoun Siba Haykal Siba Haykal |
| author_facet | Çağdaş Duru Felor Biniazan Nina Hadzimustafic Nina Hadzimustafic Andrew D'Elia Andrew D'Elia Valentina Shamoun Siba Haykal Siba Haykal |
| author_sort | Çağdaş Duru |
| collection | DOAJ |
| description | The applications of Vascularized composite allotransplantation (VCA) are increasing since the first successful hand transplantation in 1998. However, the abundance of muscle tissue makes VCA's vulnerable to ischemia-reperfusion injury (IRI), which has detrimental effects on the outcome of the procedure, restricting allowable donor-to-recipient time and limiting its widespread use. The current clinical method is Static cold storage (SCS) and this allows only 6 h before irreversible damage occurs upon reperfusion. In order to overcome this obstacle, the focus of research has been shifted towards the prospect of ex-vivo perfusion preservation which already has an established clinical role in solid organ transplants especially in the last decade. In this comprehensive qualitative review, we compile the literature on all VCA machine perfusion models and we aim to highlight the essentials of an ex vivo perfusion set-up, the different strategies, and their associated outcomes. |
| first_indexed | 2024-03-08T21:45:54Z |
| format | Article |
| id | doaj.art-40acf3c811a8450a8a674a0b60d04a18 |
| institution | Directory Open Access Journal |
| issn | 2813-2440 |
| language | English |
| last_indexed | 2024-03-08T21:45:54Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Transplantation |
| spelling | doaj.art-40acf3c811a8450a8a674a0b60d04a182023-12-20T08:44:07ZengFrontiers Media S.A.Frontiers in Transplantation2813-24402023-12-01210.3389/frtra.2023.13233871323387Review of machine perfusion studies in vascularized composite allotransplant preservationÇağdaş Duru0Felor Biniazan1Nina Hadzimustafic2Nina Hadzimustafic3Andrew D'Elia4Andrew D'Elia5Valentina Shamoun6Siba Haykal7Siba Haykal8Latner Thoracic Surgery Laboratories, University Health Network (UHN), Toronto, ON, CanadaLatner Thoracic Surgery Laboratories, University Health Network (UHN), Toronto, ON, CanadaLatner Thoracic Surgery Laboratories, University Health Network (UHN), Toronto, ON, CanadaTemerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaLatner Thoracic Surgery Laboratories, University Health Network (UHN), Toronto, ON, CanadaTemerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaLatner Thoracic Surgery Laboratories, University Health Network (UHN), Toronto, ON, CanadaLatner Thoracic Surgery Laboratories, University Health Network (UHN), Toronto, ON, CanadaPlastic and Reconstructive Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaThe applications of Vascularized composite allotransplantation (VCA) are increasing since the first successful hand transplantation in 1998. However, the abundance of muscle tissue makes VCA's vulnerable to ischemia-reperfusion injury (IRI), which has detrimental effects on the outcome of the procedure, restricting allowable donor-to-recipient time and limiting its widespread use. The current clinical method is Static cold storage (SCS) and this allows only 6 h before irreversible damage occurs upon reperfusion. In order to overcome this obstacle, the focus of research has been shifted towards the prospect of ex-vivo perfusion preservation which already has an established clinical role in solid organ transplants especially in the last decade. In this comprehensive qualitative review, we compile the literature on all VCA machine perfusion models and we aim to highlight the essentials of an ex vivo perfusion set-up, the different strategies, and their associated outcomes.https://www.frontiersin.org/articles/10.3389/frtra.2023.1323387/fullex-vivo perfusionex-vivo limb perfusionvascularized composite allograft (VCA)ischemia reperfusion (I/R) injuryhand transplantation |
| spellingShingle | Çağdaş Duru Felor Biniazan Nina Hadzimustafic Nina Hadzimustafic Andrew D'Elia Andrew D'Elia Valentina Shamoun Siba Haykal Siba Haykal Review of machine perfusion studies in vascularized composite allotransplant preservation Frontiers in Transplantation ex-vivo perfusion ex-vivo limb perfusion vascularized composite allograft (VCA) ischemia reperfusion (I/R) injury hand transplantation |
| title | Review of machine perfusion studies in vascularized composite allotransplant preservation |
| title_full | Review of machine perfusion studies in vascularized composite allotransplant preservation |
| title_fullStr | Review of machine perfusion studies in vascularized composite allotransplant preservation |
| title_full_unstemmed | Review of machine perfusion studies in vascularized composite allotransplant preservation |
| title_short | Review of machine perfusion studies in vascularized composite allotransplant preservation |
| title_sort | review of machine perfusion studies in vascularized composite allotransplant preservation |
| topic | ex-vivo perfusion ex-vivo limb perfusion vascularized composite allograft (VCA) ischemia reperfusion (I/R) injury hand transplantation |
| url | https://www.frontiersin.org/articles/10.3389/frtra.2023.1323387/full |
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