2-Oxabicyclo[2.2.2]octane as a new bioisostere of the phenyl ring

2-Oxabicyclo[2.2.2]octane as a new bioisostere of the phenyl ring

Abstract The phenyl ring is a basic structural element in chemistry. Here, we show the design, synthesis, and validation of its new saturated bioisostere with improved physicochemical properties − 2-oxabicyclo[2.2.2]octane. The design of the structure is based on the analysis of the advantages and d...

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Bibliographic Details
Main Authors: Vadym V. Levterov, Yaroslav Panasiuk, Kateryna Sahun, Oleksandr Stashkevych, Valentyn Badlo, Oleh Shablykin, Iryna Sadkova, Lina Bortnichuk, Oleksii Klymenko-Ulianov, Yuliia Holota, Leonid Lachmann, Petro Borysko, Kateryna Horbatok, Iryna Bodenchuk, Yuliia Bas, Dmytro Dudenko, Pavel K. Mykhailiuk
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41298-3

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