Comparative Analysis of Red Blood Cells, White Blood Cells, Platelet Count, and Indices in Type 2 Diabetes Mellitus Patients and Normal Controls: Association and Clinical Implications
Khaled Essawi,1 Gasim Dobie,1 Misk F Shaabi,1 Waleed Hakami,1 Muhammad Saboor,2 Aymen M Madkhali,1 Abdullah AH Hamami,3 Wael H Allallah,3 Mohammad S Akhter,1 Abdullah A Mobarki,1 Hassan A Hamali1 1Department of Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University, Jaz...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-10-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/comparative-analysis-of-red-blood-cells-white-blood-cells-platelet-cou-peer-reviewed-fulltext-article-DMSO |
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| author | Essawi K Dobie G Shaabi MF Hakami W Saboor M Madkhali AM Hamami AA Allallah WH Akhter MS Mobarki AA Hamali HA |
| author_facet | Essawi K Dobie G Shaabi MF Hakami W Saboor M Madkhali AM Hamami AA Allallah WH Akhter MS Mobarki AA Hamali HA |
| author_sort | Essawi K |
| collection | DOAJ |
| description | Khaled Essawi,1 Gasim Dobie,1 Misk F Shaabi,1 Waleed Hakami,1 Muhammad Saboor,2 Aymen M Madkhali,1 Abdullah AH Hamami,3 Wael H Allallah,3 Mohammad S Akhter,1 Abdullah A Mobarki,1 Hassan A Hamali1 1Department of Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia; 2Department of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates; 3Department of Laboratory & Blood Bank, Prince Mohammed bin Nasser Hospital, Ministry of Health, Jazan, Saudi ArabiaCorrespondence: Hassan A Hamali, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, P.O. Box 1906, Gizan, 45142, Saudi Arabia, Email hhamali@jazanu.edu.saBackground: Diabetes mellitus (DM) is a major health burden affecting 537 million adults worldwide, characterized by chronic metabolic disorder and various complications. This case control study aimed to assess the impact of type 2 diabetes mellitus (T2DM), including hyperglycemia levels, on hematological parameters and complete blood count (CBC) derived parameters.Methods: A total of 250 known diabetic patients from the Jazan Diabetic Center, Saudi Arabia, between January 2021 and December 2022, along with 175 healthy adult controls were recruited from Jazan Hospital’s blood donation center. Demographic characteristics, medical histories, and relevant factors such as gender, age, BMI, treatment, disease duration, and comorbidities were collected with informed consent.Results: The results of the red blood cell (RBC) count, RBC indices, and mean platelet volume showed significant differences between patients and controls, while the white cell (WBC) and platelet count were comparable between the two groups. CBC-derived parameters, especially neutrophil/lymphocyte ratio (NLR), and platelet/neutrophil ratio (PNR) exhibited significant differences.Conclusion: CBC and derived parameters serve as inexpensive tools for T2DM patients monitoring, indicating early blood cell alterations and potential development of anemia. Further studies are needed to explore their role in predicting T2DM pathogenesis and progression, aiming to reduce severe complications, mortality and morbidity.Keywords: diabetes mellitus, complete blood count, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, platelet/neutrophil ratio, mean platelet volume/platelet count, disease complication |
| first_indexed | 2024-03-11T18:07:00Z |
| format | Article |
| id | doaj.art-40af462ed78646faa30de2dd46fd9786 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-11T18:07:00Z |
| publishDate | 2023-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-40af462ed78646faa30de2dd46fd97862023-10-17T02:44:24ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072023-10-01Volume 163123313287200Comparative Analysis of Red Blood Cells, White Blood Cells, Platelet Count, and Indices in Type 2 Diabetes Mellitus Patients and Normal Controls: Association and Clinical ImplicationsEssawi KDobie GShaabi MFHakami WSaboor MMadkhali AMHamami AAAllallah WHAkhter MSMobarki AAHamali HAKhaled Essawi,1 Gasim Dobie,1 Misk F Shaabi,1 Waleed Hakami,1 Muhammad Saboor,2 Aymen M Madkhali,1 Abdullah AH Hamami,3 Wael H Allallah,3 Mohammad S Akhter,1 Abdullah A Mobarki,1 Hassan A Hamali1 1Department of Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia; 2Department of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates; 3Department of Laboratory & Blood Bank, Prince Mohammed bin Nasser Hospital, Ministry of Health, Jazan, Saudi ArabiaCorrespondence: Hassan A Hamali, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, P.O. Box 1906, Gizan, 45142, Saudi Arabia, Email hhamali@jazanu.edu.saBackground: Diabetes mellitus (DM) is a major health burden affecting 537 million adults worldwide, characterized by chronic metabolic disorder and various complications. This case control study aimed to assess the impact of type 2 diabetes mellitus (T2DM), including hyperglycemia levels, on hematological parameters and complete blood count (CBC) derived parameters.Methods: A total of 250 known diabetic patients from the Jazan Diabetic Center, Saudi Arabia, between January 2021 and December 2022, along with 175 healthy adult controls were recruited from Jazan Hospital’s blood donation center. Demographic characteristics, medical histories, and relevant factors such as gender, age, BMI, treatment, disease duration, and comorbidities were collected with informed consent.Results: The results of the red blood cell (RBC) count, RBC indices, and mean platelet volume showed significant differences between patients and controls, while the white cell (WBC) and platelet count were comparable between the two groups. CBC-derived parameters, especially neutrophil/lymphocyte ratio (NLR), and platelet/neutrophil ratio (PNR) exhibited significant differences.Conclusion: CBC and derived parameters serve as inexpensive tools for T2DM patients monitoring, indicating early blood cell alterations and potential development of anemia. Further studies are needed to explore their role in predicting T2DM pathogenesis and progression, aiming to reduce severe complications, mortality and morbidity.Keywords: diabetes mellitus, complete blood count, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, platelet/neutrophil ratio, mean platelet volume/platelet count, disease complicationhttps://www.dovepress.com/comparative-analysis-of-red-blood-cells-white-blood-cells-platelet-cou-peer-reviewed-fulltext-article-DMSOdiabetes mellituscomplete blood countneutrophil/lymphocyte ratioplatelet/lymphocyte ratioplatelet/neutrophil ratioand mean platelet volume/platelet countdisease complication |
| spellingShingle | Essawi K Dobie G Shaabi MF Hakami W Saboor M Madkhali AM Hamami AA Allallah WH Akhter MS Mobarki AA Hamali HA Comparative Analysis of Red Blood Cells, White Blood Cells, Platelet Count, and Indices in Type 2 Diabetes Mellitus Patients and Normal Controls: Association and Clinical Implications Diabetes, Metabolic Syndrome and Obesity diabetes mellitus complete blood count neutrophil/lymphocyte ratio platelet/lymphocyte ratio platelet/neutrophil ratio and mean platelet volume/platelet count disease complication |
| title | Comparative Analysis of Red Blood Cells, White Blood Cells, Platelet Count, and Indices in Type 2 Diabetes Mellitus Patients and Normal Controls: Association and Clinical Implications |
| title_full | Comparative Analysis of Red Blood Cells, White Blood Cells, Platelet Count, and Indices in Type 2 Diabetes Mellitus Patients and Normal Controls: Association and Clinical Implications |
| title_fullStr | Comparative Analysis of Red Blood Cells, White Blood Cells, Platelet Count, and Indices in Type 2 Diabetes Mellitus Patients and Normal Controls: Association and Clinical Implications |
| title_full_unstemmed | Comparative Analysis of Red Blood Cells, White Blood Cells, Platelet Count, and Indices in Type 2 Diabetes Mellitus Patients and Normal Controls: Association and Clinical Implications |
| title_short | Comparative Analysis of Red Blood Cells, White Blood Cells, Platelet Count, and Indices in Type 2 Diabetes Mellitus Patients and Normal Controls: Association and Clinical Implications |
| title_sort | comparative analysis of red blood cells white blood cells platelet count and indices in type 2 diabetes mellitus patients and normal controls association and clinical implications |
| topic | diabetes mellitus complete blood count neutrophil/lymphocyte ratio platelet/lymphocyte ratio platelet/neutrophil ratio and mean platelet volume/platelet count disease complication |
| url | https://www.dovepress.com/comparative-analysis-of-red-blood-cells-white-blood-cells-platelet-cou-peer-reviewed-fulltext-article-DMSO |
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